thrombospondin motifs 4 is an enzyme that in humans is encoded by the ADAMTS4 gene. This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase...
13 KB (1,619 words) - 02:57, 28 November 2023
thrombospondin motif. ADAMTS1 (or METH-1), an antiangiogenic ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 (=ADAMTS11) ADAMTS6 ADAMTS7 ADAMTS8 (or METH-2), an antiangiogenic...
5 KB (409 words) - 23:57, 18 February 2024
ADAMTS15; ADAMTS16; ADAMTS17; ADAMTS18; ADAMTS19; ADAMTS2; ADAMTS20; ADAMTS3; ADAMTS4; ADAMTS5; ADAMTS6; ADAMTS7; ADAMTS8; ADAMTS9; ADAMTSL1; ADAMTSL2; ADAMTSL3;...
6 KB (643 words) - 10:29, 22 May 2025
such as arthritis. At least two forms of aggrecanase exist in humans: ADAMTS4 or aggrecanase-1 and ADAMTS5 or aggrecanase-2. Both proteins contain thrombospondin...
3 KB (296 words) - 16:35, 12 May 2024
HGNC:217 Q9UHI8 271 ADAMTS2 HGNC:218 O95450 272 ADAMTS3 HGNC:219 O15072 273 ADAMTS4 HGNC:220 O75173 274 ADAMTS5 HGNC:221 Q9UNA0 275 ADAMTS6 HGNC:222 Q9UKP5...
277 KB (17 words) - 18:34, 6 October 2024
2008). "Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5". Protein Science. 17 (1): 16–21. doi:10.1110/ps.073287008...
12 KB (1,458 words) - 16:40, 5 June 2024
"Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90...
15 KB (1,784 words) - 07:50, 10 June 2024
articular cartilage from patients with osteoarthritis and appears to suppress ADAMTS4 (aggrecanase) activity, possibly leading to cartilage cell (chondrocyte)...
41 KB (4,894 words) - 16:41, 22 May 2025
"Brevican is degraded by matrix metalloproteinases and aggrecanase-1 (ADAMTS4) at different sites". The Journal of Biological Chemistry. 275 (49): 38885–90...
9 KB (1,088 words) - 03:54, 28 May 2025
inhibit ADAMs and ADAMTSs. TIMP3 is able to inhibit ADAM17 and 12 as well as ADAMTS4 and 5. ADAM8 and ADAM9 are not susceptible to inhibition by TIMPs. Many...
50 KB (5,459 words) - 22:55, 27 May 2025
McDonagh T, Collins-Racie LA, LaVallie ER, Morris EA, Sandy JD (May 2002). "ADAMTS4 cleaves at the aggrecanase site (Glu373-Ala374) and secondarily at the...
1 KB (128 words) - 12:58, 26 August 2023
tissue growth and regression. During folliculogenesis, ADAMTS1, along with ADAMTS4 and ADAMTS16, is upregulated by follicle-stimulating hormone (FSH), promoting...
14 KB (1,542 words) - 04:43, 19 May 2025
M311569200. PMID 14645246. Gao G, Plaas A, Thompson VP, et al. (2004). "ADAMTS4 (aggrecanase-1) activation on the cell surface involves C-terminal cleavage...
8 KB (946 words) - 01:05, 4 March 2023