Autophagy-related protein 8 (Atg8) is a ubiquitin-like protein required for the formation of autophagosomal membranes. The transient conjugation of Atg8 to the autophagosomal...
18 KB (2,085 words) - 18:55, 25 April 2024
MAP1LC3B (section The ATG8 protein family)
member of the highly conserved ATG8 protein family. ATG8 proteins are present in all known eukaryotic organisms. The animal ATG8 family comprises three subfamilies:...
40 KB (1,799 words) - 22:23, 2 December 2023
far as 30 A. It interacts with atg8 through an intermediate thioester bond between Cys-288 and the C-terminal Gly of atg8. It also interacts with the C-terminal...
6 KB (591 words) - 06:21, 1 December 2023
Atg8/Apg8/Aut7, a reaction essential for its lipidation during autophagy. Human Atg4 homologues cleave the carboxyl termini of the three human Atg8 homologues...
2 KB (225 words) - 08:07, 12 March 2021
either MAP1A or MAP1B. MAPLC3A is one of the mammalian homologues of yeast ATG8, an important marker and effector of autophagy. MAP1LC3A is regulated by...
9 KB (1,150 words) - 01:11, 5 October 2022
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
15 KB (1,777 words) - 07:49, 20 May 2025
conjugation system. The Atg12-Atg5 conjugate then promotes the conjugation of ATG8 to the lipid phosphatidylethanolamine. Atg12 was found to be involved in...
8 KB (847 words) - 01:49, 9 February 2024
ATG16L1's activity. This leads to downstream conversion of prophagophore into ATG8-positive phagophore via a ubiquitin-like conjugation system. The first of...
79 KB (9,305 words) - 18:49, 4 May 2025
ultimately linked to another protein, but there is at least one exception; ATG8 is linked to phosphatidylethanolamine. UBLs that do not exhibit covalent...
28 KB (3,106 words) - 03:25, 28 May 2025
autophagy-related ATG12-ATG5/ATG16 complex and is essentially important for the LC3 (ATG8) lipidation and autophagosome formation. This complex localizes to the membrane...
16 KB (1,731 words) - 06:41, 27 September 2024
acts like an E-1 enzyme for ubiquitin-like proteins (UBL) such as ATG12 and ATG8. ATG7 helps these UBL proteins in targeting their molecule by binding to...
7 KB (978 words) - 08:08, 18 August 2023
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
2 KB (215 words) - 03:26, 28 March 2024
in yeast, however the gene names differ. For example, LC3 in mammals is Atg8. In yeast autophagosomes are generated from Pre-Autophagosomal Structure...
11 KB (1,271 words) - 01:23, 25 April 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
1 KB (106 words) - 10:35, 13 June 2023
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
49 KB (5,534 words) - 15:15, 2 May 2025
genes control the autophagosome formation through ATG12-ATG5 and LC3-II (ATG8-II) complexes. ATG12 is conjugated to ATG5 in a ubiquitin-like reaction that...
59 KB (7,177 words) - 11:52, 4 June 2025
cerevisiae), human leukocyte antigen F-associated (FAT10), autophagy-8 (ATG8) and -12 (ATG12), Few ubiquitin-like protein (FUB1), MUB (membrane-anchored...
101 KB (11,338 words) - 19:50, 22 April 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
33 KB (3,238 words) - 16:28, 25 May 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
31 KB (3,599 words) - 03:24, 2 June 2025
a cargo receptor, binding to the ferritin heavy chain and latching on to ATG8 on the surface of the autophagosome. NCOA4 has been shown to interact with:...
14 KB (1,632 words) - 11:19, 17 October 2022
Atg8ylation is a process of conjugation of mammalian ATG8 proteins (mATG8s) to proteins or membranes. The process is akin to the ubiquitylation of diverse...
16 KB (1,693 words) - 01:43, 13 February 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
29 KB (3,502 words) - 12:50, 3 March 2025
G3BP2 G3BP2 G3BP Stress Granule Assembly Factor 2 GABARAPL2 GABARAPL2/GEF2/ATG8 GABA Type A Receptor Associated Protein Like 2 GAK GAK Cyclin G Associated...
184 KB (12,563 words) - 05:08, 10 March 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
76 KB (8,708 words) - 09:25, 13 March 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
51 KB (5,785 words) - 23:20, 15 May 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
53 KB (6,409 words) - 10:40, 24 May 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
42 KB (5,440 words) - 17:49, 26 May 2025
Gene ontology Molecular function Atg8 ligase activity protein binding Cellular component cytoplasm phagophore assembly site membrane cytosol phagocytic...
22 KB (2,808 words) - 09:48, 15 April 2024
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
5 KB (650 words) - 14:32, 17 February 2025
UBC9 E3 SUMO ligase PIAS1 PIAS2 PIAS3 PIAS4 Other ISG15 URM1 UFM1 NEDD8 (neddylation) FAT10 ATG8 ATG12 FUB1 MUB UBL5 Prokaryotic ubiquitin-like protein...
37 KB (4,317 words) - 07:27, 24 January 2025