The activated protein C resistance (APCR) test is a coagulation test used in the evaluation and diagnosis of activated protein C (APC) resistance, a form...
15 KB (1,523 words) - 11:50, 24 January 2024
Activated protein C resistance (APCR) is a hypercoagulability (an increased tendency of the blood to clot) characterized by a lack of a response to activated...
11 KB (1,036 words) - 23:10, 29 January 2023
fibrin Homogenous (activation in the whole sample volume) ETP-based activated protein C resistance test (ETP-based APCR) Thrombodynamics test Non-homogenous:...
7 KB (834 words) - 10:54, 31 July 2023
Partial thromboplastin time (redirect from Activated partial thromboplastin time)
aPTT-based activated protein C (APC) resistance test is used in the diagnosis of APC resistance (APCR). It involves a modified aPTT test performed in...
10 KB (1,064 words) - 06:52, 2 June 2025
A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses...
46 KB (5,510 words) - 21:54, 29 November 2024
Coagulation (redirect from Coagulation protein)
enzyme that is activated by thrombin into activated protein C (APC). Protein C is activated in a sequence that starts with Protein C and thrombin binding...
64 KB (6,646 words) - 14:53, 11 May 2025
Ser-63 and Ser-73 within its transcriptional activation domain. They belong to the mitogen-activated protein kinase family, and are responsive to stress...
14 KB (1,626 words) - 20:50, 30 May 2024
SOS response (section Antibiotic resistance)
around these ssDNA regions in an ATP-dependent fashion, and becomes activated. The activated form of RecA interacts with the LexA repressor to facilitate the...
13 KB (1,511 words) - 09:40, 13 April 2025
Outline of immunology (section Complement proteins)
Granuloma Acute-phase proteins Amyloid SAP SAA Positive Alpha 1-antichymotrypsin Alpha 1-antitrypsin Alpha 2-macroglobulin C-reactive protein Ceruloplasmin C3...
38 KB (2,656 words) - 20:26, 6 November 2024
Factor V Leiden (redirect from APC resistance, Leiden type)
Russell viper venom-based and activated partial thromboplastin time-based screening assays for resistance to activated protein C". American Journal of Clinical...
22 KB (2,574 words) - 19:42, 30 May 2025
ABCC1 (redirect from Multidrug resistance-associated protein 1)
multi-drug resistance. This protein functions as a multispecific organic anion transporter, with oxidized glutathione, cysteinyl leukotrienes, and activated aflatoxin...
13 KB (1,849 words) - 08:43, 30 April 2024
triggered immunity (ETI) is activated by the presence of pathogen effectors. The ETI response is reliant on R genes, and is activated by specific pathogen strains...
66 KB (7,550 words) - 22:49, 1 June 2025
molecules, including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also serve as PDK2. Phosphorylation...
35 KB (3,831 words) - 20:54, 25 May 2025
Thrombin generation assay (redirect from Thrombin generation test)
under the curve of the thrombin generation curve) The addition of activated protein C (APC) to a TGA results in an inhibition of thrombin generation as...
6 KB (614 words) - 06:17, 13 August 2023
Pokeweed antiviral protein and the Zinc-Finger antiviral protein are two major antiviral proteins that have undergone several tests for viruses, including...
6 KB (649 words) - 18:46, 14 November 2024
activation since dCas9 has modifiable regions, typically the N and C terminus of the protein, that can be used to attach transcriptional activators....
22 KB (2,739 words) - 08:03, 1 April 2025
Mechanosensitive channels (redirect from Stretch-activated ion channel)
when protein channels are activated by a mechanical stimulus. There are currently two models of the gating process that explain how membrane-activated ion...
66 KB (7,825 words) - 22:28, 16 July 2024
Calibrated automated thrombogram (category Blood tests)
thrombin potential (ETP) and to assess activated protein C resistance (APCR). The CAT ETP-based APC resistance test is especially sensitive to estrogen-induced...
7 KB (720 words) - 04:42, 3 December 2023
exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated guanine nucleotide exchange factor I (cAMP-GEFI) is a protein that in humans is encoded...
30 KB (3,461 words) - 22:11, 24 August 2024
prion protein (PrP) is encoded in the human body by the PRNP gene also known as CD230 (cluster of differentiation 230). Expression of the protein is most...
45 KB (5,160 words) - 15:37, 21 April 2025
BRAF (gene) (section Activation loop)
B-Raf is activated, a conserved protein kinase catalytic core phosphorylates protein substrates by promoting the nucleophilic attack of the activated substrate...
50 KB (5,393 words) - 08:57, 15 March 2025
Heat shock proteins (HSPs) are a family of proteins produced by cells in response to exposure to stressful conditions. They were first described in relation...
49 KB (5,534 words) - 15:15, 2 May 2025
Gestational diabetes (redirect from O'sullivan test)
as the protein levels increase with c-MET is not present. Another hypothesis says that c-MET may control β-cell apoptosis because a lack of c-MET causes...
92 KB (11,197 words) - 13:04, 22 May 2025
Cross-link (redirect from Protein crosslinking)
Upon exposure to ultraviolet light, the diazirines are activated and bind to interacting proteins that are within a few ångströms of the photo-reactive...
18 KB (1,797 words) - 10:15, 25 May 2025
triggering the activation of AMP-activated protein kinase (AMPK) which subsequently phosphorylates peroxisome proliferator-activated receptor gamma coactivator-1α...
84 KB (10,916 words) - 15:08, 24 May 2025
Lupus anticoagulant (redirect from Lupus Anticoagulant Test)
paradox" may be explained by platelet activation as described above, as well as enhancement of activated protein C resistance and suppression of the anticoagulant...
16 KB (1,863 words) - 14:26, 7 February 2025
the direct protein targets of action of ceramide. These include enzymes called ceramide-activated Ser-Thr phosphatases (CAPPs), such as protein phosphatase...
55 KB (5,633 words) - 08:40, 12 July 2024
Thrombophilia (section Timing of Testing)
and thrombin-activatable fibrinolysis inhibitor, and decreased levels of tissue factor pathway inhibitor. Activated protein C resistance that is not attributable...
47 KB (5,588 words) - 18:49, 22 May 2025
involving genes, proteins, and altered pathways, to ensure their survival against antineoplastic drugs. Antineoplastic resistance, synonymous with chemotherapy...
35 KB (3,844 words) - 19:47, 22 May 2025
MTOR (redirect from FK506 binding protein 12-rapamycin associated protein 1)
they called dominant rapamycin resistance 1 and 2 (DRR1 and DRR2), in studies published in October 1993. The protein, now called mTOR, was originally...
120 KB (12,683 words) - 14:54, 2 June 2025