In immunology, affinity maturation is the process by which TFH cell-activated B cells produce antibodies with increased affinity for antigen during the...

recalled in a secondary immune response, undergoing class switching, affinity maturation, and differentiating into antibody-secreting cells. Antibodies are...

increase or decrease the affinity of the surface receptor for a particular antigen, a progression called affinity maturation. After acquiring these mutations...

production, germinal center formation and isotype switching, and affinity maturation and memory cell generation. It also refers to the effector functions...

plasmablasts, have antibodies with a higher affinity towards their target antigen due to affinity maturation in the germinal center (GC) and produce more...

and the affinity increased 1-5 million fold to low picomolar values through phage display affinity maturation. To provide the soluble, affinity enhanced...

contain lymphoid follicles with germinal centers where B cells undergo affinity maturation. They are covered by stratified squamous epithelium, and the tissue...

confront it (e.g. microbes). A major component of the process of affinity maturation, SHM diversifies B cell receptors used to recognize foreign elements...

not have high affinity for antigen, mutations in the FR that create a more flexible structure may allow for higher affinity maturation. Natural mutations...

undergo a process known as affinity maturation. This process favors, by selection for the ability to bind antigen with higher affinity, the activation and growth...

activity can be highly specific is the antibody-antigen system. Affinity maturation typically leads to highly specific interactions, whereas naive antibodies...

and under modulation by T cells, and is closely intertwined with affinity maturation. B cells that respond most avidly to antigen are preferentially allowed...

time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen-antibody...

the formation of germinal centers and therefore prohibits antibody affinity maturation, an important process in the adaptive immune system. In 1991, three...

activation by antigens. Activation leads to clonal selection and affinity maturation. Mature lymphocytes recirculate between the blood and the secondary...

produce. This phenomenon underscores the process of affinity maturation, whereby greater affinity antibodies are produced and selected for after antigen...

hence prevail. Conversely, antibodies also simultaneously evolve by affinity maturation during the course of an immune response, thereby improving recognition...

MacKenzie, C.; Hall, J. Christopher (2007-07-01). "Isolation and affinity maturation of hapten-specific antibodies". Biotechnology Advances. 25 (4): 333–352...

(January 2007). "Imaging of germinal center selection events during affinity maturation". Science. 315 (5811): 528–31. Bibcode:2007Sci...315..528A. doi:10...

entered the CSF and underwent affinity maturation after facing GlialCAM, which led consequently to the production of high-affinity anti-GlialCAM antibodies...

DR, Barbas CF (December 1995). "CDR walking mutagenesis for the affinity maturation of a potent human anti-HIV-1 antibody into the picomolar range"....

activated by a T cell, a B cell can undergo antibody isotype switching, affinity maturation, as well as formation of memory cells. Non-professional antigen presenting...

ligands in drug discovery, in silico mutagenesis studies and antibody affinity maturation. For the study of reactions it is often necessary to involve a quantum-mechanical...

time called affinity maturation. These algorithms focus on the Darwinian attributes of the theory where selection is inspired by the affinity of antigen–antibody...

oligonucleotide displaying a known binder to the target, thus enabling affinity maturation strategies. Two individual sublibraries can be assembled combinatorially...

temperatures or in harsh solvents Improving binding affinity of therapeutic antibodies (Affinity maturation) and the activity of de novo designed enzymes Altering...

cells undergo affinity maturation, which improves the strength of their antibodies' binding to a specific antigen. B cells, with higher affinity antibodies...

isotype is 7 fold. This implies that bNAbs develop from intense affinity maturation in the germinal centers hence the reason for high sequence variability...

faster and bind more strongly with it (i.e., greater affinity of binding) owing to affinity maturation. The soluble antibodies produced by the clone show...

(2010). "Bacterial Display Enables Efficient and Quantitative Peptide Affinity Maturation". Protein Eng Des Sel. 23 (1): 9–17. doi:10.1093/protein/gzp065....