A basic helix–loop–helix (bHLH) is a protein structural motif that characterizes one of the largest families of dimerizing transcription factors. The word...
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Basic helix-loop-helix ARNT-like protein 1 or aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL), or brain and muscle ARNT-like 1 is...
50 KB (5,803 words) - 04:21, 21 January 2025
expression. It should not be confused with the helix–loop–helix motif. The discovery of the helix-turn-helix motif was based on similarities between several...
24 KB (1,411 words) - 03:34, 12 July 2025
Class A basic helix-loop-helix protein 15 (bHLHa15) also known as class B basic helix-loop-helix protein 8 (bHLHb8) or muscle, intestine and stomach expression...
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Helix is a database management system for the Apple Macintosh platform, created in 1983. Helix uses a graphical "programming language" to add logic to...
12 KB (1,883 words) - 18:24, 25 April 2025
Basic helix-loop-helix leucine zipper transcription factors are, as their name indicates, transcription factors containing both Basic helix-loop-helix...
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"Basic helix-loop-helix family, member e41", or BHLHE41, is a gene that encodes a basic helix-loop-helix transcription factor repressor protein in various...
27 KB (3,029 words) - 05:13, 19 July 2025
for enzymatic reactions. The formation of a stem-loop is dependent on the stability of the helix and loop regions. The first prerequisite is the presence...
6 KB (739 words) - 21:09, 14 October 2024
Medicine 2019 was awarded for the discovery of HIF. HIF1A is a basic helix-loop-helix PAS domain containing protein, and is considered as the master transcriptional...
65 KB (7,427 words) - 10:18, 18 July 2025
are encoded by the genes SREBF1 and SREBF2. SREBPs belong to the basic-helix-loop-helix leucine zipper class of transcription factors. Unactivated SREBPs...
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conserved residue of TWIST2 (twist-related protein 2). TWIST2 is a basic helix-loop-helix transcription factor that binds to E-box DNA motifs (5'-CANNTG-3')...
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proteins that suppress transcription. This protein belongs to the basic helix-loop-helix (bHLH) family of transcription factors. It is a transcriptional...
23 KB (2,892 words) - 17:31, 16 July 2025
proteins known as myogenic regulatory factors (MRFs). These bHLH (basic helix loop helix) transcription factors act sequentially in myogenic differentiation...
27 KB (3,389 words) - 17:32, 17 July 2025
Pho4 is a protein with a basic helix-loop-helix (bHLH) transcription factor. It is found in S. cerevisiae and other yeasts. It functions as a transcription...
7 KB (859 words) - 14:06, 17 September 2022
A basic helix–loop–helix protein 38 (bHLHa38) is a basic helix-loop-helix transcription factor that in humans is encoded by the TWIST1 gene. Basic helix-loop-helix...
20 KB (2,365 words) - 07:38, 19 July 2025
humans is encoded by the TAL1 gene. The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 has been shown to interact with: CBFA2T3...
11 KB (1,404 words) - 18:31, 17 July 2025
regulating transcriptional activity. These proteins usually contain the basic helix-loop-helix protein structural motif, which allows them to bind as dimers. This...
30 KB (3,663 words) - 17:40, 30 June 2025
Proneural genes encode transcription factors of the basic helix-loop-helix (bHLH) class which are responsible for the development of neuroectodermal progenitor...
48 KB (5,028 words) - 20:35, 3 March 2025
activator encoded by the MYOG gene. Myogenin is a muscle-specific basic-helix-loop-helix (bHLH) transcription factor involved in the coordination of skeletal...
12 KB (1,497 words) - 08:24, 26 March 2024
embryonic day 12 (E12). It is a member of the Neurod family of basic helix-loop-helix (bHLH) transcription factors, composed of Neurod1, Neurod2, Neurod4...
12 KB (1,400 words) - 05:22, 5 August 2024
consisted of a helix-loop-helix (HLH) domain. The microprotein formed bHLH/HLH heterodimers which disrupted the functional basic helix–loop–helix (bHLH) homodimers...
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myogenesis. Both MyoD and Myf5 are members of the myogenic bHLH (basic helix-loop-helix) proteins transcription factor family. Cells that make myogenic...
24 KB (2,799 words) - 18:01, 16 July 2025
as oxygen concentration falls (hypoxia). The protein contains a basic helix-loop-helix protein dimerization domain as well as a domain found in signal...
22 KB (2,685 words) - 05:43, 19 July 2025
CLOCK (section Role in other feedback loops)
for circadian locomotor output cycles kaput) is a gene encoding a basic helix-loop-helix-PAS transcription factor that is known to affect both the persistence...
33 KB (3,940 words) - 16:06, 10 June 2024
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene...
16 KB (1,978 words) - 06:42, 19 July 2025
structural motif known as the basic helix-loop-helix (bHLH). This motif is characterized by two alpha helices connected by a loop, which allows for a compact...
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Pho regulon, a bacterial phosphate regulatory mechanism Pho4, a basic helix-loop-helix transcription factor Phos, a genus of sea snails This disambiguation...
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differentiation. The aryl hydrocarbon receptor is a member of the family of basic helix-loop-helix transcription factors. AhR binds several exogenous ligands such...
52 KB (6,002 words) - 19:56, 11 July 2025
DNA-binding domain (section Helix-loop-helix)
basic helix-loop-helix (bHLH) domain is found in some transcription factors and is characterized by two alpha helices (α-helixes) connected by a loop...
20 KB (2,348 words) - 17:08, 16 July 2025
Single-minded homolog 1, also known as class E basic helix-loop-helix protein 14 (bHLHe14), is a protein that in humans is encoded by the SIM1 gene. The...
11 KB (1,379 words) - 07:17, 19 July 2025