Cellular stress response is the wide range of molecular changes that cells undergo in response to environmental stressors, including extremes of temperature...
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The integrated stress response is a cellular stress response conserved in eukaryotic cells that downregulates protein synthesis and upregulates specific...
13 KB (1,625 words) - 04:45, 28 October 2024
The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. It has been found to be conserved...
31 KB (3,654 words) - 17:39, 10 May 2025
The heat shock response (HSR) is a cell stress response that increases the number of molecular chaperones to combat the negative effects on proteins caused...
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include improve lifespan and fitness, by activating the animal's cellular stress response. This may be useful to evolve, as it gives possible cues about...
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The mitochondrial unfolded protein response (UPRmt) is a cellular stress response related to the mitochondria. The UPRmt results from unfolded or misfolded...
17 KB (1,878 words) - 03:38, 2 December 2024
The bacterial stress response enables bacteria to survive adverse and fluctuating conditions in their immediate surroundings. Various bacterial mechanisms...
16 KB (2,187 words) - 04:10, 9 May 2025
Proteostasis (section Cell-autonomous stress responses)
organism from anticipated proteotoxic stress. Cellular stress response pathways detect and alleviate proteotoxic stress which is triggered by imbalances in...
25 KB (2,922 words) - 18:48, 4 May 2025
Heat shock protein (section Upregulation in stress)
part of a cell's own repair system, called the "cellular stress response" or the "heat-shock response". Recently, there are several studies that suggest...
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understanding of cellular aging molecular pathways. Cellular senescence can be initiated by a wide variety of stress inducing factors. These stress factors include...
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species act as cellular messengers in redox signaling. Thus, oxidative stress can cause disruptions in normal mechanisms of cellular signaling.[citation...
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Lipopolysaccharide (section Cellular senescence)
work demonstrating that TLR4 is the LPS receptor. As part of the cellular stress response, superoxide is one of the major reactive oxygen species induced...
63 KB (7,187 words) - 01:02, 11 May 2025
human-specific brain development, tumor suppression, and the cellular stress response. GADD45G interacts with several other proteins that are involved...
25 KB (3,081 words) - 06:55, 24 December 2023
XBP1 (section Endoplasmic reticulum stress response)
important to the proper functioning of the immune system and in the cellular stress response. The X-box binding protein 1 (XBP1) is a transcription factor containing...
12 KB (1,418 words) - 02:31, 30 August 2024
In cellular biology, stress granules are biomolecular condensates in the cytosol composed of proteins and RNA that assemble into 0.1–2 μm membraneless...
184 KB (12,563 words) - 05:08, 10 March 2025
is thought to function in the cellular stress response pathway. The kinase is activated in response to hypotonic stress, leading to phosphorylation of...
5 KB (605 words) - 21:42, 3 March 2023
unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum. The UPR is activated in response to an accumulation...
33 KB (3,692 words) - 23:24, 13 May 2025
In cell biology and pathophysiology, cellular adaptation refers to changes made by a cell in response to adverse or varying environmental changes. The...
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RAGE (mRAGE): mRAGE acts as a cellular receptor capable of activating inflammatory and oxidative stress pathways in response to ligand binding. The receptor's...
57 KB (6,867 words) - 15:23, 12 March 2025
mitochondrial diseases. Mitochondrial fission plays a role in the cellular stress response and in apoptosis (programmed cell death). The Drp1 protein, a member...
10 KB (1,386 words) - 17:54, 12 November 2024
human HtrA2, a novel serine protease involved in the mammalian cellular stress response". European Journal of Biochemistry. 267 (18): 5699–710. doi:10...
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a stimulus or stressor (usually a chemical) after a certain exposure time. Dose–response relationships can be described by dose–response curves. This is...
17 KB (1,778 words) - 21:04, 18 May 2025
Bafilomycin (section Cellular action)
suggest that inhibition of V-ATPase with bafilomycin can induce a cellular stress response, including autophagy and eventual apoptosis. These somewhat contradictory...
40 KB (4,672 words) - 14:16, 10 September 2024
activate death receptors, stimulate apoptotic pathways, or initiate cellular stress response in the endoplasmic reticulum. These lipotoxic effects have been...
12 KB (1,458 words) - 17:24, 23 July 2024
Osmotic shock (redirect from Osmotic stress)
"Intracellular water homeostasis and the mammalian cellular osmotic stress response". Journal of Cellular Physiology. 206 (1): 9–15. doi:10.1002/jcp.20445...
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allow for the cellular defense against pro-oxidative conditions. There is a feedback regulation balance between reductive and oxidative stress where chronic...
8 KB (909 words) - 16:25, 20 May 2024
cell division while simultaneously activating a cellular stress response named ribotoxic stress response. The trichothecene mycotoxins can be absorbed though...
49 KB (5,688 words) - 15:30, 1 April 2025
γ34.5 gene in viruses such as herpes simplex virus; it blocks a cellular stress response to viral infection. It shares the C-terminal regulatory domain...
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Moskowitz JT, et al. (August 2009). "Can meditation slow rate of cellular aging? Cognitive stress, mindfulness, and telomeres". Ann N Y Acad Sci. 1172 (1): 34–53...
12 KB (1,195 words) - 04:01, 20 January 2025
stress (tissue adaptive syndrome) is an unspecific adaptive reaction universal for all tissues of adult organism which forms in tissue as a response to...
12 KB (1,701 words) - 04:41, 24 May 2023