Complement factor B is a protein that in humans is encoded by the CFB gene. This gene encodes complement factor B, a component of the alternative pathway...
9 KB (1,095 words) - 16:58, 16 July 2025
of complement component 3, complement factor B, and complement factor I, as well as deletion of complement factor H-related 3 and complement factor H-related...
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Complement factor I, also known as C3b/C4b inactivator, is a protein that in humans is encoded by the CFI gene. Complement factor I (factor I) is a protein...
18 KB (2,240 words) - 16:09, 17 July 2025
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan...
15 KB (1,004 words) - 06:05, 22 June 2025
Macular degeneration (section Risk factors)
location 10q26 Complement Factor B/Complement Component 2 (CFB/CC2) on chromosome 6 at 6p21.3[citation needed] Polymorphisms in genes for complement system proteins:...
91 KB (9,880 words) - 23:19, 2 August 2025
Factor H (FH) is a soluble glycoprotein and a member of the regulators of complement activation (RCA) family. It functions as a complement control protein...
31 KB (3,694 words) - 05:47, 19 July 2025
Complement decay-accelerating factor, also known as CD55 or DAF, is a protein that, in humans, is encoded by the CD55 gene. DAF regulates the complement...
8 KB (962 words) - 17:05, 16 July 2025
activation process: Complement Receptor 1 (CR1 or CD35) and DAF (decay accelerating factor also known as CD55) compete with Factor B in binding with C3b...
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partnership with Ionis Pharmaceuticals. It targets complement factor B (CFB) to treat complement system-mediated diseases, primarily IgA nephropathy...
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agent. Factor I can cleave C3b into C3c and C3d, the latter of which plays a role in enhancing B cell responses. In the alternative complement pathway...
15 KB (1,758 words) - 16:58, 16 July 2025
of paroxysmal nocturnal hemoglobinuria and proteinuria. It is a complement factor B inhibitor that was developed by Novartis. It is taken by mouth. Iptacopan...
21 KB (4,272 words) - 03:39, 24 March 2025
Factor D (EC 3.4.21.46, C3 proactivator convertase, properdin factor D esterase, factor D (complement), complement factor D, CFD, adipsin) is a protein...
18 KB (2,047 words) - 23:18, 16 August 2023
major histocompatibility complex class III region linking complement genes C4, C2 and factor B". Nature. 307 (5948): 237–41. Bibcode:1984Natur.307..237C...
35 KB (4,189 words) - 16:09, 17 July 2025
C3-convertase (redirect from Classical-complement-pathway C3/C5 convertase)
complement activation. After cleavage and binding to cell surface, the C3b fragment is ready to bind a plasma protein called Factor B. The Factor B (a...
10 KB (1,319 words) - 01:19, 29 November 2024
IC3b (category Complement system)
part of the complement system, a component of the vertebrate immune system. iC3b is produced when complement factor I cleaves C3b. Complement receptors...
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Alternative-complement-pathway C3/C5 convertase (EC 3.4.21.47, complement component C3/C5 convertase (alternative), proenzyme factor B, properdin factor B, C3...
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pathway of immune system complement activation Transcription factor, a protein that binds to specific DNA sequences Factor (programming language), a...
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Membrane-bound complement regulators Membrane Cofactor Protein, MCP (CD46) Decay Accelerating Factor, DAF (CD55) Protectin (CD59) Complement C3b/C4b Receptor...
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Pfam clan). The vWA domain is found in various plasma proteins: complement factors B, C2, CR3 and CR4; the integrins (I-domains); collagen types VI, VII...
8 KB (794 words) - 01:54, 16 June 2025
Index of biochemistry articles (section B)
inhibition - complement 3A - complement 5A - complement factor B - complement membrane attack complex - complement receptor - complex - computational biology...
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regulated without C3b inactivation, through complement control proteins, including decay-accelerating factors that function to speed up C3 convertase half-lives...
17 KB (2,036 words) - 05:36, 19 February 2024
"Structure and activation of complement components C2 and factor B". Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences...
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glycoprotein of the complement system; decay-accelerating factor (DAF: CD55: Cromer antigen) protects host cells from complement-mediated damage by regulating...
22 KB (2,904 words) - 16:58, 16 July 2025
Von Willebrand factor, type C (VWFC or VWC)is a protein domain is found in various blood plasma proteins: complement factors B, C2, CR3 and CR4; the integrins...
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Macrophage-1 antigen (redirect from Complement receptor 3)
Macrophage-1 antigen (hereafter complement receptor 3 or CR3) (CD11b/CD18) is a human cell surface receptor found on B and T lymphocytes, polymorphonuclear...
9 KB (1,147 words) - 01:46, 25 November 2024
proposed to be a major factor in the maintenance of sexual reproduction among eukaryotes. Further, the selective advantage of complementation that arises from...
12 KB (1,476 words) - 18:27, 23 August 2024
C5-convertase (category Complement system)
(C3bBbC3b) of complement system. Two fluid phase C5 convertases have been described: the classical pathway enzyme, C4b2boxy3b and the cobra venom factor-dependent...
12 KB (1,660 words) - 03:36, 19 December 2024
Complement component 1 Q subcomponent-binding protein, mitochondrial is a protein that in humans is encoded by the C1QBP gene. The human complement subcomponent...
13 KB (1,621 words) - 15:53, 17 July 2025
classical complement pathway and thus requires functioning C1-C9 factors. If an individual has deficient or malfunctioning complement factors, then at...
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