• Thumbnail for Cyclic nucleotide
    A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides...
    21 KB (2,416 words) - 02:58, 25 May 2025
  • Thumbnail for Cyclic nucleotide–gated ion channel
    Cyclic nucleotide–gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic nucleotides. CNG channels are...
    39 KB (4,917 words) - 18:22, 22 December 2024
  • Thumbnail for Cyclic nucleotide-binding domain
    Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues. The best studied of these proteins is the prokaryotic...
    4 KB (327 words) - 09:18, 28 May 2025
  • and a cyclic nucleotide-binding domain (CNBD) in the C-terminus. HCN isoforms are highly conserved in their core transmembrane regions and cyclic nucleotide...
    14 KB (1,568 words) - 21:13, 10 September 2024
  • Thumbnail for Cyclic nucleotide phosphodiesterase
    5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate...
    7 KB (821 words) - 20:38, 7 December 2023
  • Thumbnail for Cyclic adenosine monophosphate
    function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2. cAMP is associated with kinases...
    18 KB (1,794 words) - 06:03, 2 June 2025
  • Thumbnail for G protein
    G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in...
    24 KB (2,754 words) - 17:11, 18 October 2024
  • Thumbnail for HCN1
    roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels"...
    13 KB (1,478 words) - 04:31, 16 June 2023
  • Thumbnail for Cyclic nucleotide gated channel beta 3
    Cyclic nucleotide gated channel beta 3, also known as CNGB3, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel Stargardt...
    7 KB (819 words) - 00:05, 30 January 2023
  • Thumbnail for CREB
    facilitates binding to DNA. The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'-TGACGTCA-3’...
    19 KB (2,243 words) - 23:46, 9 September 2024
  • Oxidoreductase NAD-binding domain is an evolutionary conserved protein domain present in a variety of proteins that include, bacterial flavohemoprotein...
    4 KB (222 words) - 15:35, 19 June 2023
  • Thumbnail for HCN2
    roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels"...
    9 KB (1,098 words) - 03:06, 19 August 2024
  • Thumbnail for Cyclic ADP-ribose
    Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine...
    12 KB (1,183 words) - 04:51, 16 January 2025
  • Thumbnail for Cyclic di-GMP
    domains change conformation drastically upon binding to cyclic di-GMP. This leads to the strong inference that conformational changes in PilZ domains...
    9 KB (935 words) - 05:15, 5 May 2025
  • Thumbnail for GAF domain
    in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP...
    3 KB (364 words) - 04:52, 30 August 2021
  • Thumbnail for CGMP-specific phosphodiesterase type 5
    cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis. The interest in PDEs...
    18 KB (2,100 words) - 20:19, 29 May 2025
  • Thumbnail for Nicotinamide adenine dinucleotide
    a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other...
    81 KB (9,207 words) - 19:16, 31 May 2025
  • Thumbnail for Cyclic nucleotide-gated channel alpha 1
    Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously expressed CNGA1 can form...
    10 KB (1,149 words) - 07:11, 29 April 2025
  • Thumbnail for Cyclic nucleotide-gated channel alpha 3
    Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene. This gene encodes a member of the cyclic nucleotide-gated...
    9 KB (971 words) - 16:44, 27 December 2023
  • furthermore, a putative cyclic nucleotide-binding homology domain, which name is CNBH (Cyclic Nucleotide-Binding Homology). The CBS-pair domain has been extensively...
    14 KB (1,708 words) - 16:25, 24 May 2024
  • Thumbnail for Cyclic nucleotide-gated channel alpha 2
    Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:...
    4 KB (534 words) - 09:19, 31 July 2023
  • Thumbnail for CREB-binding protein
    Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational...
    52 KB (5,272 words) - 02:33, 25 May 2025
  • Thumbnail for Cyclic nucleotide-gated channel alpha 4
    Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene. CNGA4 is a modulatory subunit of vertebrate cyclic...
    4 KB (419 words) - 00:25, 4 March 2023
  • Thumbnail for NOD2
    Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory...
    13 KB (1,530 words) - 12:06, 2 November 2024
  • Thumbnail for Phosphodiesterase
    breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are...
    15 KB (1,718 words) - 13:00, 2 November 2024
  • PDE1 [2]. The binding of one Ca2+/CaM complex per monomer to binding sites near the N-terminus stimulates hydrolysis of cyclic nucleotides. In intact cells...
    22 KB (2,564 words) - 01:35, 14 June 2024
  • Thumbnail for G protein-coupled receptor
    G-protein coupling. This is made possible by a guanine-nucleotide exchange factor (GEF) domain primarily formed by a combination of IL-2 and IL-3 along...
    82 KB (9,408 words) - 13:15, 23 May 2025
  • Thumbnail for Adenylyl cyclase
    interacting with and regulating other proteins such as protein kinase A and cyclic nucleotide-gated ion channels. Photoactivated adenylyl cyclase (PAC) was discovered...
    23 KB (2,570 words) - 00:50, 28 March 2025
  • Thumbnail for ABCC11
    ABCC11 (category ATP-binding cassette transporters)
    processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a single nucleotide polymorphism (SNP) in this gene is responsible for...
    22 KB (2,428 words) - 06:39, 2 June 2025
  • Thumbnail for CNGB1
    Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:...
    5 KB (632 words) - 22:31, 16 July 2024