A cyclic nucleotide (cNMP) is a single-phosphate nucleotide with a cyclic bond arrangement between the sugar and phosphate groups. Like other nucleotides...
21 KB (2,416 words) - 02:58, 25 May 2025
Cyclic nucleotide–gated ion channels or CNG channels are ion channels that function in response to the binding of cyclic nucleotides. CNG channels are...
39 KB (4,917 words) - 18:22, 22 December 2024
Proteins that bind cyclic nucleotides (cAMP or cGMP) share a structural domain of about 120 residues. The best studied of these proteins is the prokaryotic...
4 KB (327 words) - 09:18, 28 May 2025
and a cyclic nucleotide-binding domain (CNBD) in the C-terminus. HCN isoforms are highly conserved in their core transmembrane regions and cyclic nucleotide...
14 KB (1,568 words) - 21:13, 10 September 2024
5′-cyclic-nucleotide phosphodiesterases (EC 3.1.4.17) are a family of phosphodiesterases. Generally, these enzymes hydrolyze a nucleoside 3′,5′-cyclic phosphate...
7 KB (821 words) - 20:38, 7 December 2023
function of ion channels such as the HCN channels and a few other cyclic nucleotide-binding proteins such as Epac1 and RAPGEF2. cAMP is associated with kinases...
18 KB (1,794 words) - 06:03, 2 June 2025
G protein (redirect from Guanine nucleotide binding proteins)
G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside cells, and are involved in...
24 KB (2,754 words) - 17:11, 18 October 2024
HCN1 (redirect from Hyperpolarization-activated cyclic nucleotide-gated channel 1)
roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels"...
13 KB (1,478 words) - 04:31, 16 June 2023
Cyclic nucleotide gated channel beta 3, also known as CNGB3, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel Stargardt...
7 KB (819 words) - 00:05, 30 January 2023
CREB (redirect from Cyclic amp response element-binding protein a)
facilitates binding to DNA. The cAMP response element (CRE) is the response element for CREB which contains the highly conserved nucleotide sequence, 5'-TGACGTCA-3’...
19 KB (2,243 words) - 23:46, 9 September 2024
Oxidoreductase NAD-binding domain is an evolutionary conserved protein domain present in a variety of proteins that include, bacterial flavohemoprotein...
4 KB (222 words) - 15:35, 19 June 2023
roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels"...
9 KB (1,098 words) - 03:06, 19 August 2024
Cyclic ADP-ribose, frequently abbreviated as cADPR, is a cyclic adenine nucleotide (like cAMP) with two phosphate groups present on 5' OH of the adenosine...
12 KB (1,183 words) - 04:51, 16 January 2025
domains change conformation drastically upon binding to cyclic di-GMP. This leads to the strong inference that conformational changes in PilZ domains...
9 KB (935 words) - 05:15, 5 May 2025
in five members of the cyclic nucleotide phosphodiesterase superfamily: PDE2, PDE5, and PDE6 which bind cGMP to the GAF domain, PDE10 which binds cAMP...
3 KB (364 words) - 04:52, 30 August 2021
CGMP-specific phosphodiesterase type 5 (redirect from Cyclic GMP Phosphodiesterase)
cone photoreceptor cells of the retina, belong to a large family of cyclic nucleotide PDEs that catalyze cAMP and cGMP hydrolysis. The interest in PDEs...
18 KB (2,100 words) - 20:19, 29 May 2025
Nicotinamide adenine dinucleotide (redirect from Diphosphopyridine nucleotide)
a dinucleotide because it consists of two nucleotides joined through their phosphate groups. One nucleotide contains an adenine nucleobase and the other...
81 KB (9,207 words) - 19:16, 31 May 2025
Cyclic nucleotide-gated channel alpha 1, also known as CNGA1, is a human gene encoding an ion channel protein. Heterologously expressed CNGA1 can form...
10 KB (1,149 words) - 07:11, 29 April 2025
Cyclic nucleotide-gated cation channel alpha-3 is a protein that in humans is encoded by the CNGA3 gene. This gene encodes a member of the cyclic nucleotide-gated...
9 KB (971 words) - 16:44, 27 December 2023
Metal transporter CNNM3 (section CNBH domain)
furthermore, a putative cyclic nucleotide-binding homology domain, which name is CNBH (Cyclic Nucleotide-Binding Homology). The CBS-pair domain has been extensively...
14 KB (1,708 words) - 16:25, 24 May 2024
Cyclic nucleotide gated channel alpha 2, also known as CNGA2, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:...
4 KB (534 words) - 09:19, 31 July 2023
Potential Opportunities in CBP [Cyclic Adenosine Monophosphate (cAMP) Response Element-Binding Protein (CREB)-Binding Protein] Research Using Computational...
52 KB (5,272 words) - 02:33, 25 May 2025
Cyclic nucleotide-gated cation channel alpha-4 is a protein that in humans is encoded by the CNGA4 gene. CNGA4 is a modulatory subunit of vertebrate cyclic...
4 KB (419 words) - 00:25, 4 March 2023
NOD2 (redirect from Nucleotide-binding oligomerization domain containing 2)
Nucleotide-binding oligomerization domain-containing protein 2 (NOD2), also known as caspase recruitment domain-containing protein 15 (CARD15) or inflammatory...
13 KB (1,530 words) - 12:06, 2 November 2024
breaks a phosphodiester bond. Usually, phosphodiesterase refers to cyclic nucleotide phosphodiesterases, which have great clinical significance and are...
15 KB (1,718 words) - 13:00, 2 November 2024
PDE1 (redirect from 5'-nucleotide phosphodiesterase)
PDE1 [2]. The binding of one Ca2+/CaM complex per monomer to binding sites near the N-terminus stimulates hydrolysis of cyclic nucleotides. In intact cells...
22 KB (2,564 words) - 01:35, 14 June 2024
G-protein coupling. This is made possible by a guanine-nucleotide exchange factor (GEF) domain primarily formed by a combination of IL-2 and IL-3 along...
82 KB (9,408 words) - 13:15, 23 May 2025
interacting with and regulating other proteins such as protein kinase A and cyclic nucleotide-gated ion channels. Photoactivated adenylyl cyclase (PAC) was discovered...
23 KB (2,570 words) - 00:50, 28 March 2025
ABCC11 (category ATP-binding cassette transporters)
processes involving bile acids, conjugated steroids, and cyclic nucleotides. In addition, a single nucleotide polymorphism (SNP) in this gene is responsible for...
22 KB (2,428 words) - 06:39, 2 June 2025
CNGB1 (redirect from Cyclic nucleotide-gated channel beta 1)
Cyclic nucleotide gated channel beta 1, also known as CNGB1, is a human gene encoding an ion channel protein. Cyclic nucleotide-gated ion channel GRCh38:...
5 KB (632 words) - 22:31, 16 July 2024