G1/S-specific cyclin-E1 is a protein that in humans is encoded by the CCNE1 gene. The protein encoded by this gene belongs to the highly conserved cyclin family...

and cyclin E1. By inhibiting mir-424 in normal endothelial cells they could observe the same increased protein expression of MEK1 and cyclin E1 which...

A cyclin-dependent kinase inhibitor protein (also known as CKIs, CDIs, or CDKIs) is a protein which inhibits the enzyme cyclin-dependent kinase (CDK) and...

Cyclin E is a member of the cyclin family. Cyclin E binds to G1 phase Cdk2, which is required for the transition from G1 to S phase of the cell cycle...

transcription factor. Cyclin-dependent kinase 2 has been shown to interact with: BRCA1, CDK2AP1, CDKN1B CDKN3, CEBPA, Cyclin A1, Cyclin E1, Flap structure-specific...

promote entry into S phase. Eukaryotic cells possess two types of cyclin, cyclin E1 and cyclin E2, with the protein sequences sharing 69.3% similarity in humans...

Palbociclib is less effective in patients whose breast cancer cells overexpress cyclin E1 or E2, and Brk (breast tumor-related kinase). Brk is an intracellular...

Cyclin B is a member of the cyclin family. Cyclin B is a mitotic cyclin. The amount of cyclin B (which binds to Cdk1) and the activity of the cyclin B-Cdk...

V.; Cook, A.; Brown, N. R.; Johnson, L. N. (2005). "The structure of cyclin E1/CDK2: Implications for CDK2 activation and CDK2-independent roles". The...

cell cycle progression through Cyclin E1. More specifically, DDX3X was shown to directly bind to the 5´ UTR of Cyclin E1 and thereby facilitating the translation...

has been shown to interact with: AKT1, CKS1B, Cyclin D3, Cyclin E1, Cyclin-dependent kinase 2, Cyclin-dependent kinase 4, Grb2, NUP50 SKP2, SPDYA, and...

carcinoma harboring KRAS mutations resulted in upregulation of cyclin D1, CDK4, and cyclin E1, negating the effects of administering the drug. Malumbres et...

may regulate the activation of cell cycle progression by upregulating cyclin E1 and downregulating p27Kip1 (Busser et al., 1998; Yang et al., 2003). Alzheimer...

receptors and Wilm tumor suppressor 1. The CCNE1 gene encodes for the cyclin E1 protein which accumulates at the G1-S phase transition point of the cell...

by the absence of cyclin E1 and/or the inhibition of the cyclin-E1–CDK2 complex by p21, p27, and p53. Next, the absence of cyclin A1 commits the neuron...

suppressor protein RhoBTB2. CUL3 has been shown to interact with: CAND1, Cyclin E1, DCUN1D1, KEAP1, and KLHL12. GRCh38: Ensembl release 89: ENSG00000036257...

degradation. SKP2 targets p27Kip-1, an inhibitor of cyclin-dependent kinases (CDKs). CDKs2/4 partner with the cyclins E/D, respectively, forming a family of cell...

controlled by cyclin and cyclin-dependent kinases. The progression of interphase is the result of the increased amount of cyclin. As the amount of cyclin increases...

releasing the E2F family of transcription factors (inducing CyclinE expression). Additionally, Cyclin E1 is more easily replicated in BLBC than other types of...

M, Yoshizato K, Ikeda K, Kawada N (October 2011). "Down-regulation of cyclin E1 expression by microRNA-195 accounts for interferon-β-induced inhibition...

human papillomavirus. HERC5 has been shown to interact with NME2 and Cyclin E1. GRCh38: Ensembl release 89: ENSG00000138646 – Ensembl, May 2017 "Human...

homolog E1 (Xenopus laevis)". Dinarina A, Perez LH, Davila A, Schwab M, Hunt T, Nebreda AR (March 2005). "Characterization of a new family of cyclin-dependent...

Retinoblastoma-like protein 2 has been shown to interact with: BRCA1, BRF1 C-Raf, Cyclin E1, Cyclin-dependent kinase 2, HDAC1, Prohibitin, and RBBP8. Pocket protein family...

key players in cell cycle control, mediating the degradation of cyclins, as well as cyclin dependent kinase inhibitor proteins. The human genome encodes...

example of E2F-regulated genes repressed by pRb are cyclin E and cyclin A. Both of these cyclins are able to bind to Cdk2 and facilitate entry into the...

such as the G1/S phase transition. Earlier cyclin-CDK complexes provide the signal to activate subsequent cyclin-CDK complexes. There are thousands of distinct...

cellular proteins after its C-terminal tail is processed. The NEDD8 activating E1 enzyme is a heterodimer composed of APPBP1 and UBA3 subunits. The APPBP1/UBA3...

ordered action of cyclin-dependent kinases (CDKs), activated by specific cyclins that demarcate phases of the cell cycle. Mitotic cyclins, which persist...

activation and inactivation of cyclin-dependent kinases (Cdks, CDKs). Specifically it is the interactions of cyclins and cyclin dependent kinases that are...

by E1, an ATP-dependent ubiquitin activating enzyme. The carboxyl terminal (C-terminus) of ubiquitin is linked to the cysteine residue of the E1 protein...