The D2-like receptors are a subfamily of dopamine receptors that bind the endogenous neurotransmitter dopamine. The D2-like subfamily consists of three...

dopamine receptors, D1, D2, D3, D4, and D5. The D1 and D5 receptors are members of the D1-like family of dopamine receptors, whereas the D2, D3 and D4...

Dopamine receptor D2, also known as D2R, is a protein that, in humans, is encoded by the DRD2 gene. After work from Paul Greengard's lab had suggested...

prostaglandin D2 (PGD2) receptors are G protein-coupled receptors that bind and are activated by prostaglandin D2. Also known as PTGDR or DP receptors, they are...

dopamine receptors. There are two families of dopamine receptors, D1-like and D2-like. They are all G protein-coupled receptors. D1- and D5-receptors belong...

D1-like class of dopamine receptors is coupled to Gαs/olf and stimulates adenylate cyclase production, whereas the D2-like class is coupled to Gαi/o and...

respective main articles of the individual subtypes: D2-like receptor "Dopamine D1-Like Receptor Family Signaling Pathways". Rndsystems. 26 March 2022...

receptor antagonists can be divided into D1-like receptor antagonists and D2-like receptor antagonists. Ecopipam is an example of a D1-like receptor antagonist...

14-fold selectivity for D1-like receptors over D2 Dihydrexidine – full agonist with 10-fold selectivity for D1-like receptors over D2 that has been in Phase...

reported. D2-like receptor agonists are known to have sedative-like and non-rewarding effects in humans. In any case, dopamine D2-like receptor antagonists...

The dopamine receptor D4 is a dopamine D2-like G protein-coupled receptor encoded by the DRD4 gene on chromosome 11 at 11p15.5. The structure of DRD4 has...

models, cataplexy is regulated by the dopaminergic system via the D2-like receptor, which when blocked decreases cataplectic attacks.[clarification needed]...

the D2-like receptors (D2, D3, D4) (Ki ≥ 4,870 to 6,720 nM). Tavapadon also shows biased agonism for Gs-coupled signaling at the D1-like receptors. As...

dopamine receptors are a superfamily of heptahelical G protein-coupled receptors, and are grouped into two categories, D1-like (D1, D5) and D2-like (D2, D3...

selectivity for the D3 receptor over the D2, D4, and D5 receptors and 100-fold selectivity for the D3 receptor over the D1 receptor. In functional studies...

as a D3 and D2 receptor partial agonist, with a preference for the D3 receptor. It is a partial agonist at the serotonin 5-HT1A receptor and acts as an...

Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major prostaglandin produced by mast...

Rhodopsin-like receptors are a family of proteins that comprise the largest group of G protein-coupled receptors. G-protein-coupled receptors, GPCRs, constitute...

engagement at the dopamine receptor (D2). Aripiprazole is a partial agonist at dopamine D2 receptors, a partial agonist at 5-HT1A receptors, and an antagonist...

prostaglandin D2 receptor 1 (DP1), a G protein-coupled receptor encoded by the PTGDR gene (also termed PTGDR1), is primarily a receptor for prostaglandin D2 (PGD2)...

Sceletium tortuosum (kanna)) Roxindole (EMD-49,980) (also a 5-HT1A and D2-like receptor agonist) Dopamine reuptake inhibitor Monoamine reuptake inhibitor Tatsumi...

The D1–D2 dopamine receptor heteromer is a receptor heteromer consisting of D1 and D2 protomers. D1 and D2 receptors interact primarily through discrete...

with some similar efficacy than a full antagonist (like perphenazine) at the D2 receptor, so a receptor occupation of only 68+% at the maximum recommended...

box") between D1 and D2. This "acid box" can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient...

dopamine D2-like receptors and reduce dopaminergic neurotransmission, low doses of amisulpride preferentially block presynaptic dopamine D2 and D3 autoreceptors...

known as deuterated nemonapride enantiomer, is a selective dopamine D2 and D3 receptor antagonist which is under development for the treatment of major depressive...

as a non-selective dopamine receptor agonist, including of the D1-like receptors (D1, D5) and the D2-like receptors (D2, D3, D4). The bioavailability...

for the PCP/NMDA receptor (Ki > 10000 nM), D2-like receptors (Ki = 327 nM), serotonin 5-HT2 receptors (Ki = 53 nM), and opioid receptors (Ki > 10000 nM)...

dopamine D2 receptor reaches around 70%. Dopamine D2 receptor partial agonists like aripiprazole are likewise active in the test. Serotonin 5-HT2A receptor antagonists...

avolition and alogia. Abnormal expression, thus distribution of the D2 receptor between these areas and the rest of the brain may also be implicated...