DNA-dependent protein kinase catalytic subunit, also known as DNA-PKcs, is an enzyme that plays a crucial role in repairing DNA double-strand breaks and...
32 KB (3,754 words) - 05:22, 30 September 2024
Topoisomerase (redirect from Dna topoisomerases)
components of the non-homologous end joining DNA repair pathway, including DNA-PKcs, Ku70/Ku80 and DNA ligase IV assembled with topo IIβ and PARP-1....
57 KB (6,181 words) - 06:46, 2 June 2025
Non-homologous end joining (category DNA repair)
forms a complex with DNA-PKcs, which is present in mammals but absent in yeast. Ku is a basket-shaped molecule that slides onto the DNA end and translocates...
29 KB (3,755 words) - 17:20, 16 April 2025
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
97 KB (11,166 words) - 18:24, 9 June 2025
2004). "Shorter telomeres, accelerated ageing and increased lymphoma in DNA-PKcs-deficient mice". EMBO Reports. 5 (5): 503–09. doi:10.1038/sj.embor.7400127...
132 KB (16,142 words) - 16:06, 11 June 2025
one DNA-dependent protein kinase catalytic subunit (DNA-PKcs) to the DNA ends to enable the binding of Artemis protein to one end of each DNA-PKcs. One...
43 KB (5,681 words) - 00:50, 14 June 2024
Severe combined immunodeficiency (category DNA replication and repair-deficiency disorders)
Esguerra, Z; Watanabe, G; Okitsu, CY; Hsieh, CL; Lieber, MR (April 2020). "DNA-PKcs chemical inhibition versus genetic mutation: Impact on the junctional repair...
34 KB (3,270 words) - 10:18, 10 May 2025
the 469 kDa DNA-dependent protein kinase (DNA-PKcs) to gain endonuclease activity on hairpins and the 5' and 3' overhangs; the DNA-PKcs phosphorylates...
3 KB (467 words) - 14:59, 15 March 2022
Klaus; Lieber, Michael (2005). "The Artemis:DNA-PKcs Endonuclease Cleaves DNA Loops, Flaps, and Gaps". DNA Repair. 4 (7): 845–851. doi:10.1016/j.dnarep...
21 KB (2,860 words) - 00:58, 15 January 2025
Double-strand break repair model (category DNA repair)
recruitment of various NHEJ factors, such as the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), DNA Ligase IV and X-ray cross complementing protein...
41 KB (5,013 words) - 21:06, 15 June 2025
Winters TA, Georgakilas AG (2010). "DNA-PKcs deficiency leads to persistence of oxidatively induced clustered DNA lesions in human tumor cells". Free...
43 KB (3,770 words) - 18:03, 27 November 2024
Memory (section DNA methylation and demethylation)
enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80, and DNA LIGASE IV) (see Figure). These enzymes repair the...
138 KB (16,946 words) - 10:34, 2 July 2025
there is a DNA test to determine if a given horse is a carrier of the allele. The only known form of horse SCID involves mutation in DNA-PKcs. Unlike SCID...
11 KB (1,429 words) - 23:09, 27 May 2025
lamin A, lamin B1, lamin B2, PARP (poly ADP ribose polymerase), and DNA-PKcs (DNA-activated protein kinase). The final result is apoptosis of the cell...
31 KB (3,853 words) - 11:23, 9 January 2025
Artemis (protein) (section Repair of DNA breaks)
combined immunodeficiency (SCIDA). DCLRE1C has been shown to interact with DNA-PKcs. GRCh38: Ensembl release 89: ENSG00000152457 – Ensembl, May 2017 GRCm38:...
15 KB (1,937 words) - 16:28, 9 December 2024
(PI3Ks). This protein kinase family includes ATR (ATM- and RAD3-related), DNA-PKcs (DNA-dependent protein kinase catalytic subunit) and mTOR (mammalian target...
50 KB (5,695 words) - 13:00, 26 February 2025
Sirtuin 6 (section DNA repair)
DNA double-strand breaks by the process of non-homologous end joining and homologous recombination. SIRT6 stabilizes the repair protein DNA-PKcs (DNA-dependent...
9 KB (1,087 words) - 23:32, 7 June 2025
Nuclease (section DNA repair)
reaction. Although Artemis exhibits 5' → 3' ssDNA exonuclease activity when alone, its complexing with DNA-PKcs allows for endonucleasic processing of the...
22 KB (2,538 words) - 09:39, 13 February 2025
four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see figure). These enzymes repair the double-strand...
37 KB (4,291 words) - 11:37, 2 June 2025
inhibitors target proteins (PARP family) and kinases (ATM, DNA-PKCs) that are involved in DNA repair. Indirect inhibitors target protein tumor cell signaling...
30 KB (3,757 words) - 06:51, 24 June 2025
Werner syndrome (category DNA replication and repair-deficiency disorders)
depends on DNA, it is only functional when localized to the nucleus.[citation needed] The finding that WRN protein interacts with DNA-PKcs and the Ku...
35 KB (4,494 words) - 20:10, 29 June 2025
P53 (section DNA damage and repair)
CEBPZ, CDC14A, Cdk1, CFLAR, CHEK1, CCNG1, CREBBP, CREB1, Cyclin H, CDK7, DNA-PKcs, E4F1, EFEMP2, EIF2AK2, ELL, EP300, ERCC6, GNL3, GPS2, GSK3B, HSP90AA1...
128 KB (13,927 words) - 21:09, 29 June 2025
Evolution of ageing (section DNA damage/error theory)
cancers, and atherosclerosis. The finding that WRN protein interacts with DNA-PKcs and the Ku protein complex, combined with evidence that WRN deficient cells...
55 KB (6,854 words) - 18:34, 28 June 2025
Ataxia–telangiectasia (category DNA replication and repair-deficiency disorders)
Alt FW, Nussenzweig A, Nussenzweig M (May 2009). "Essential role for DNA-PKcs in DNA double-strand break repair and apoptosis in ATM-deficient lymphocytes"...
83 KB (10,923 words) - 20:02, 29 May 2025
although it can also inhibit other PI3K-related enzymes such as mTOR, DNA-PKcs, some phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK)...
12 KB (1,138 words) - 05:28, 7 May 2024
P. H.; Williams J. G.; Pears C. J.; Lakin N. D. (2005). "DNA-PKcs-dependent signaling of DNA damage in Dictyostelium discoideum". Curr Biol. 15 (20):...
40 KB (5,249 words) - 04:09, 30 June 2025
Molecular lesion (section DNA Damage Response)
phosphatidylinositol 3-kinase-related kinases (PIKK), and range from DNA-dependent protein kinase (DNA-PKcs) and ataxia telangiectasia-mutated (ATM) most involved in...
29 KB (3,552 words) - 17:53, 31 October 2024
Werner syndrome ATP-dependent helicase has been shown to interact with: BLM DNA-PKcs, FEN1, Ku70, Ku80, P53, PCNA, TERF2, WRNIP1, RNF4, and PIAS4. GRCh38: Ensembl...
33 KB (4,150 words) - 13:37, 10 April 2025
four enzymes of the non-homologous end joining (NHEJ) DNA repair pathway (DNA-PKcs, KU70, KU80 and DNA LIGASE IV) (see Figure). These enzymes repair the double-strand...
53 KB (6,243 words) - 18:48, 28 May 2025
respiratory tract infections. This condition is due to mutations in the DNA-PKcs gene and is inheritable in an autosomal recessive fashion. The gene is...
3 KB (374 words) - 04:49, 12 November 2023