is caused by a genetic mutation leading to deregulation of the DUX4 gene. Normally, DUX4 is expressed (i.e., turned on) only in select human tissues, most...
176 KB (16,445 words) - 12:26, 23 May 2025
Double homeobox, 4 also known as DUX4 is a protein which in humans is encoded by the DUX4 gene. Its misexpression is the cause of facioscapulohumeral muscular...
7 KB (709 words) - 21:41, 1 February 2025
p38α/β mitogen-activated protein kinases (MAPKs), which are modulators of DUX4 expression and mediators of inflammation. Losmapimod was discovered and unsuccessfully...
14 KB (1,239 words) - 04:20, 8 March 2025
Dickkopf-related protein 2 DMAC1: encoding protein Transmembrane protein 261 DUX4: Thought to be inactive but 2010 research shows a key role in FSHD ELMOD2:...
31 KB (1,931 words) - 14:30, 20 April 2025
CIC-DUX4 gene may cause an aggressive Ewing-like sarcoma. Instead of acting as a suppressor, a hybrid protein produced by fusion of CIC and DUX4 has been...
12 KB (1,435 words) - 00:30, 4 July 2024
conduction defects and arrhythmias. Facioscapulohumeral muscular dystrophy 158900 DUX4 AD Adolescence Face, shoulders, upper arms, progressing to other muscles...
30 KB (2,269 words) - 01:16, 26 May 2025
oligonucleotides called gapmers that knock down the expression of a toxic gene called DUX4 in cell and mouse models for the treatment of facioscapulohumeral muscular...
29 KB (2,765 words) - 23:24, 23 April 2025
DUX3_HUMAN Homeodomain Known motif – In vivo/Misc source [167] TTAATTAAATTAA DUX4 ENSG00000260596 Homeodomain Known motif – In vivo/Misc source [168] TGATTRRRTTA...
374 KB (81 words) - 11:17, 3 January 2025
HGNC:3078 P33316 4611 DUX1 HGNC:3079 O43812 4612 DUX3 HGNC:3081 Q96PT4 4613 DUX4 HGNC:50800 Q9UBX2 4614 DUX5 HGNC:3083 Q96PT3 4615 DUXA HGNC:32179 A6NLW8...
277 KB (17 words) - 18:34, 6 October 2024
dystrophy (FSHD) on the basis of p38 inhibition inhibiting the effects of DUX4. Cosgrove BD, Gilbert PM, Porpiglia E, Mourkioti F, Lee SP, Corbel SY, Llewellyn...
14 KB (1,385 words) - 10:32, 28 April 2024
Idiopathic Pulmonary Fibrosis In clinic, Phase 1 ARO-COV Covid-19 Preclinical ARO-DUX4 FSHD Preclinical HZN-457 Gout In clinic, Phase 1 Partnered with Horizon...
6 KB (336 words) - 03:22, 26 January 2025
number Encoded genes Non-coding RNA Clinical relevance D4Z4 4, 10 3.3 1-150 DUX4 DBE-T FSHD DXZ4 X 3 50-100 None X-inactivation RS447 4 4.7 20-103 USP17 NBL2...
4 KB (307 words) - 20:48, 27 May 2025
mitogen-activated protein kinase (MAPK) inhibitor and double homeobox 4 (DUX4) inhibitor LU-AA34893 (LU-AA-34893) – serotonin receptor modulator LU-AA39959...
151 KB (11,540 words) - 04:49, 20 May 2025
Antoine; et al. (2012). "High prevalence of CIC fusion with double homeobox (DUX4) transcription factors in EWSR1-negative undifferentiated small round blue...
10 KB (1,022 words) - 06:56, 30 May 2023
M.G., Aihara, H., Kyba, M. (2016). DNA-binding sequence specificity of DUX4. Skelet Muscle 6(8). doi:10.1186/s13395-016-0080-z. PMID 26823969 S2CID 3514854...
10 KB (924 words) - 18:56, 28 May 2025
Bou Saada Y, Dib C, Ansseau E, Barat A, Hamade A, et al. (October 2016). "DUX4-induced constitutive DNA damage and oxidative stress contribute to aberrant...
13 KB (1,269 words) - 12:33, 25 April 2025