The Evolutionary Classification of Protein Domains (ECOD) is a biological database that classifies protein domains available from the Protein Data Bank...

Structural Classification of Proteins (SCOP) database is a largely manual classification of protein structural domains based on similarities of their structures...

A protein family is a group of evolutionarily related proteins. In many cases, a protein family has a corresponding gene family, in which each gene encodes...

structure. Many proteins consist of several domains, and a domain may appear in a variety of different proteins. Molecular evolution uses domains as building...

function of the protein they belong to; for example, the "calcium-binding domain of calmodulin". Because they are independently stable, domains can be "swapped"...

eukaryotic proteins have multiple domains while about 40-60% of prokaryotic proteins have multiple domains. Over time, many of the superfamilies of domains have...

classification databases (SCOP and CATH). All-α proteins are a class of structural domains in which the secondary structure is composed entirely of α-helices...

The three-domain system is a taxonomic classification system that groups all cellular life into three domains, namely Archaea, Bacteria and Eukarya, introduced...

The CATH Protein Structure Classification database is a free, publicly available online resource that provides information on the evolutionary relationships...

of biological systematics, the Linnaean system has transformed into a system of modern biological classification intended to reflect the evolutionary...

A protein with several domains may use these domains for functional interactions with different molecules. Family (sequence context) a group of proteins...

terms of evolutionary and functional similarity. This may use either whole proteins or protein domains, especially in multi-domain proteins. Protein domains...

The two-domain system is a biological classification by which all organisms in the tree of life are classified into two domains, Bacteria and Archaea...

C-terminal domain, while type III have their N-terminal domains targeted to the ER lumen. Type IV is subdivided into IV-A, with their N-terminal domains targeted...

either three domains, Archaea, Bacteria, and Eukarya, or two domains, Archaea and Bacteria, with Eukarya included in Archaea. In the three-domain model, the...

by other ATPase domains within the same oligomeric structure. The additional domains in the protein allow for regulation or direction of the force towards...

Protein quaternary structure is the fourth (and highest) classification level of protein structure. Protein quaternary structure refers to the structure...

alpha proteins (domains consisting of alpha helices), all beta proteins (domains consisting of beta sheets), and mixed alpha helix/beta sheet proteins. While...

Structural Classification of Proteins database (SCOP) provides a detailed and comprehensive description of the structural and evolutionary relationships of known...

major virion protein itself or MGEs that are clearly demonstrable to be members of a line of evolutionary descent of such major virion protein-encoding entities...

tyrosine protein kinases. The domain consists of two sub-domains referred to as the N- and C-terminal domains. The N-terminal domain consists of five beta...

"Valid publication of names of two domains and seven kingdoms of prokaryotes". International Journal of Systematic and Evolutionary Microbiology. 74 (1)...

database of protein families, protein domains and functional sites in which identifiable features found in known proteins can be applied to new protein sequences...

The general purpose of the Pfam database is to provide a complete and accurate classification of protein families and domains. Originally, the rationale...

and a homeodomain. The LIM domains function in protein-protein interactions and can bind zinc molecules. LIM domain proteins are found in both the cytosol...

Domains are functional, structural, and evolutionary units that form proteins. Domains of common Ancestry are grouped into superfamilies. The domains...

of further protein domains with differing function. The extra domains often regulate the activity of the DNA-binding domain. The function of DNA binding...

signature proteins have no homology to proteins in other domains of life, but appear to be universal among eukaryotes. They include the proteins of the cytoskeleton...

phylogeny is a graphical representation which shows the evolutionary history between a set of species or taxa during a specific time. In other words,...

metallo-β-lactamase (MBL) superfamily constitutes a group of proteins found in all domains of life that share a characteristic αββα fold with the ability...