fibroblast growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor...
25 KB (3,126 words) - 16:03, 10 June 2025
The fibroblast growth factor receptors (FGFR) are, as their name implies, receptors that bind to members of the fibroblast growth factor (FGF) family of...
8 KB (827 words) - 14:53, 16 April 2025
via specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was...
22 KB (2,698 words) - 15:56, 25 May 2025
Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2...
14 KB (1,745 words) - 09:02, 15 July 2024
Fibroblast growth factor receptor 3 (FGFR-3) is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333 (cluster...
17 KB (1,844 words) - 17:19, 16 July 2025
Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome...
44 KB (5,007 words) - 01:23, 16 July 2025
Fibroblast growth factor 1 (FGF-1) also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1...
20 KB (2,311 words) - 17:19, 16 July 2025
Fibroblast growth factor 23 (FGF-23) is a protein and member of the fibroblast growth factor (FGF) family which participates in the regulation of phosphate...
16 KB (1,825 words) - 02:04, 12 July 2025
Fibroblast growth factor 21 (FGF-21) is a protein that in mammals is encoded by the FGF21 gene. The protein encoded by this gene is a member of the fibroblast...
24 KB (3,058 words) - 19:13, 30 June 2025
outgrowth of neurites in PC12 cells. FGF18 signals through fibroblast growth factor receptor (FGFR) family, preferentially binding FGFR 3c (followed by...
16 KB (1,816 words) - 08:23, 17 July 2025
repair, and tumor progression. FGF8 signals primarily through fibroblast growth factor receptor 1 (FGFR1) to trigger downstream pathways involved in neural...
21 KB (2,541 words) - 04:13, 9 June 2025
Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster...
10 KB (1,291 words) - 09:08, 15 July 2024
Fibroblast growth factor 5(FGF5) Fibroblast growth factor 6(FGF6) Fibroblast growth factor 7(FGF7) Fibroblast growth factor 8(FGF8) Fibroblast growth...
10 KB (1,131 words) - 18:45, 6 May 2025
Receptor tyrosine kinases (RTKs) are the high-affinity cell surface receptors for many polypeptide growth factors, cytokines, and hormones. Of the 90...
28 KB (3,078 words) - 17:48, 25 January 2025
Activation of other growth factor receptors such as fibroblast growth factor receptors or epidermal growth factor receptor can also be responsible. Acanthosis...
18 KB (1,783 words) - 07:18, 24 June 2025
epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family...
60 KB (6,879 words) - 01:06, 1 March 2025
Pfeiffer syndrome (category Cell surface receptor deficiencies)
big toes. Pfeiffer syndrome is caused by mutations in the fibroblast growth factor receptors FGFR1 and FGFR2. The syndrome is grouped into three types:...
15 KB (1,440 words) - 22:09, 15 July 2025
Fibroblast growth factor receptor-like 1 is a protein that in humans is encoded by the FGFRL1 gene. The protein encoded by this gene is a member of the...
6 KB (842 words) - 01:10, 27 January 2024
Craniosynostosis (section Biomechanical factors)
found in the fibroblast growth factor receptor 3 (FGFR3) and TWIST genes. Fibroblast growth factor and fibroblast growth factor receptors regulate fetal...
72 KB (7,727 words) - 21:00, 24 February 2025
FGF5 (redirect from Fibroblast growth factor 5)
Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene. The majority of FGF family members are glycosaminoglycan binding proteins...
19 KB (2,251 words) - 15:12, 25 April 2024
targeting vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Ofev was developed by Boehringer...
36 KB (3,141 words) - 01:15, 30 June 2025
natriuretic peptide receptor type B (NPR-B), which reduces the activity of fibroblast growth factor receptor 3 (FGFR3). FGFR3 is a receptor that normally down-regulates...
19 KB (1,329 words) - 22:33, 29 May 2025
viz., FGF19 and FGF21) to their fibroblast growth factor receptors, is promoted via their interactions as co-receptors with β-klotho. Loss of β-Klotho...
38 KB (4,151 words) - 04:21, 15 July 2025
Cholangiocarcinoma (section Risk factors)
Infigratinib (Truseltiq) is a tyrosine kinase inhibitor of fibroblast growth factor receptor (FGFR) that was approved for medical use in the United States...
74 KB (7,710 words) - 01:04, 16 June 2025
FRS3 (redirect from Fibroblast growth factor receptor substrate 3)
Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by this gene is a substrate...
6 KB (734 words) - 05:08, 29 December 2023
Achondroplasia (category Growth disorders)
immunodeficiency. Achondroplasia is caused by a mutation in the fibroblast growth factor receptor 3 (FGFR3) gene that results in its protein being overactive...
47 KB (4,447 words) - 18:59, 16 July 2025
Crouzon syndrome (category Cell surface receptor deficiencies)
gene on chromosome 10 that controls the body's production of fibroblast growth factor receptor 2 (FGFR2). Crouzon syndrome is named for Octave Crouzon, a...
12 KB (1,264 words) - 14:16, 24 May 2025
responding to this growth factor, TrkB (pronounced "Track B") and the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). It may...
50 KB (5,881 words) - 13:31, 5 May 2025
anti-cancer medication. It is a small molecule inhibitor of fibroblast growth factor receptor (FGFR) used for the treatment of cancer. FGFRs are a subset...
17 KB (1,368 words) - 20:45, 29 May 2025
fibroblast growth factor (FGF) activates a signaling pathway that positively regulates the PDGF receptors in OPCs. PDGF was one of the first growth factors...
24 KB (2,882 words) - 15:04, 24 May 2025