GTP-binding protein regulators regulate G proteins in several different ways. Small GTPases act as molecular switches in signaling pathways, which act...

Receptors stimulate GTP binding (turning the G protein on). RGS proteins stimulate GTP hydrolysis (creating GDP, thus turning the G protein off). All eukaryotes...

ability to bind guanosine triphosphate (GTP). Binding of GTP inherently changes the activity of the G proteins and increases their activity, through the...

RGS13, RGS14, RGS16, RGS17, RGS18, RGS19, RGS20, RGS21 SNX13 GTP-binding protein regulators: GEF GAP Coleman DE, Berghuis AM, Lee E, Linder ME, Gilman AG...

Nuclear protein) also known as GTP-binding nuclear protein Ran is a protein that in humans is encoded by the RAN gene. Ran is a small 25 kDa protein that...

for nuclear transport and Rab and Arf for vesicle transport. GTP-binding protein regulators Wennerberg K, Rossman KL, Der CJ (March 2005). "The Ras superfamily...

triphosphate (GTP). As the name implies, Ras-GTPases possess intrinsic enzymatic activity that hydrolyses GTP to GDP and phosphate. Thus, upon binding to GTP, the...

factor) ability, which activates the G-protein by exchanging the GDP on the alpha subunit to GTP. The binding of GTP to the alpha subunit results in a structural...

activating protein (IQGAP) is a carrier protein. It is associated with the Rho GTP-binding protein. IQGAP1, IQGAP2, IQGAP3 IQ calmodulin-binding motif v...

(GTP) and hydrolyze it to guanosine diphosphate (GDP). The GTP binding and hydrolysis takes place in the highly conserved P-loop "G domain", a protein...

(GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine...

proteins (GAPs). As per its classification, Ras has an intrinsic GTPase activity, which means that the protein on its own will hydrolyze a bound GTP molecule...

gtp-binding protein alpha subunit, gi2 MeSH D12.776.476.375.100.300 – gtp-binding protein alpha subunits, gq-g11 MeSH D12.776.476.375.100.400 – gtp-binding...

an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate...

PMC 2665304. PMID 17035353. Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo"...

mutagenesis has shown these regions to play a critical role in the binding of Rab proteins. Dirac-Svejstrup AB, Sumizawa T, Pfeffer SR (February 1997). "Identification...

protein's activity, either enhancing or inhibiting its function. In contrast, substances that bind directly to an enzyme's active site or the binding...

nucleotide-binding proteins that function in the transduction of signals that control cell growth and differentiation. Binding of GTP activates RAS proteins, and...

to RanGTP, displaces Importin-α from the cargo. The NLS-protein is thus free in the nucleoplasm. The Importinβ-RanGTP and Importinα-CAS-RanGTP complex...

RNA-binding attenuation protein (TRAP protein) in species of Bacillus and related bacteria. This protein is encoded by the MtrB gene. TRAP protein forms...

mostly identical, with the N-terminal containing most of the protein coding for GTP binding and hydrolysis. The C-terminal of RhoA is modified via prenylation...

hemoglobin-like proteins whose known and predicted roles include the reversible binding of gaseous ligands. Since many of these proteins contain globins...

function as regulators of vesicular traffic and actin remodelling. The small ADP ribosylation factor (Arf) GTP-binding proteins are major regulators of vesicle...

the uptake systems also have an extracytoplasmic receptor, a solute binding protein. Some homologous ATPases function in non-transport-related processes...

downstream effector protein of the small GTPase Rho, which is one of the major regulators of the cytoskeleton. 1. ROCK is a key regulator of actin organization...

an associated G protein by exchanging the GDP bound to the G protein for a GTP. The G protein's α subunit, together with the bound GTP, can then dissociate...

whether the allosteric sites are functional. The allosteric regulators of GLUD1 - ADP, GTP, Leu, NAD+ and NADH - exert their effects by changing the energy...

MeSH D12.776.377.715.085.740 – progesterone-binding globulin MeSH D12.776.377.715.085.750 – retinol-binding proteins MeSH D12.776.377.715.085.901 – transcortin...

release and GTP binding to specific Small GTPases of the Rho family (e.g., Rac and Cdc42), leading to their activation since Rho proteins are inactive...

1992). "Escherichia coli cell-division gene ftsZ encodes a novel GTP-binding protein". Nature. 359 (6392): 251–254. Bibcode:1992Natur.359..251R. doi:10...