• Thumbnail for Growth factor-like domain
    A growth factor-like domain (GFLD) is a protein domain structurally related to epidermal growth factor, which has a high binding affinity for the epidermal...
    1 KB (132 words) - 20:57, 11 September 2020
  • Thumbnail for EGF-like domain
    The EGF-like domain is an evolutionary conserved protein domain, which derives its name from the epidermal growth factor where it was first described....
    16 KB (1,785 words) - 11:31, 27 May 2025
  • Thumbnail for Insulin-like growth factor 2
    Insulin-like growth factor 2 (IGF-2) is one of three protein hormones that share structural similarity to insulin. The MeSH definition reads: "A well-characterized...
    15 KB (1,901 words) - 19:51, 2 April 2025
  • Thumbnail for Insulin-like growth factor 1
    Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in...
    34 KB (4,512 words) - 06:26, 2 May 2025
  • Thumbnail for Laron syndrome
    insulin-like growth factor 1 (IGF-1; somatomedin-C) production in response to growth hormone (GH; hGH; somatotropin). It is usually caused by inherited growth hormone...
    29 KB (2,892 words) - 21:17, 29 May 2025
  • Thumbnail for Factor IX
    N-terminal epidermal growth factor-like domain in factor IX and factor X represents an important recognition motif for binding to tissue factor". The Journal...
    34 KB (1,994 words) - 04:50, 15 September 2024
  • Thumbnail for Insulin-like growth factor-binding protein
    The insulin-like growth factor-binding protein (IGFBP) serves as a transport protein for insulin-like growth factor 1 (IGF-1). Approximately 98% of IGF-1...
    4 KB (468 words) - 09:09, 29 January 2023
  • Thumbnail for Amyloid-beta precursor protein
    individual domains have been successfully crystallized, the growth factor-like domain, the copper-binding domain, the complete E1 domain and the E2 domain. Amyloid-beta...
    51 KB (5,489 words) - 15:39, 23 May 2025
  • Thumbnail for Fibroblast growth factor receptor 2
    Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 (cluster of differentiation 332) is a protein that in humans is encoded by the FGFR2...
    14 KB (1,745 words) - 09:02, 15 July 2024
  • Thumbnail for Heparin-binding EGF-like growth factor
    EGF-like growth factor (HB-EGF) is a member of the EGF family of proteins that in humans is encoded by the HBEGF gene. HB-EGF-like growth factor is synthesized...
    20 KB (2,598 words) - 14:07, 21 July 2024
  • Thumbnail for Multiple Epidermal Growth Factor-like Domains 8
    Megf8 also known as Multiple Epidermal Growth Factor-like Domains 8, is a protein coding gene that encodes a single pass membrane protein, known to participate...
    35 KB (3,523 words) - 13:53, 28 May 2025
  • Thumbnail for Alliinase
    Many alliinases contain a novel N-terminal epidermal growth factor-like domain (EGF-like domain). These enzymes are found in plants of the genus Allium...
    7 KB (668 words) - 16:17, 26 March 2025
  • Thumbnail for Neuregulin 1
    and epidermal growth factor-like (EGF-like) domains. GGF and GGF2 isoforms contain a kringle-like sequence plus Ig and EGF-like domains; and the SMDF...
    39 KB (4,466 words) - 11:06, 20 April 2025
  • Thumbnail for Epidermal growth factor
    Epidermal growth factor (EGF) is a protein that stimulates cell growth and differentiation by binding to its receptor, EGFR. Human EGF is 6-kDa and has...
    17 KB (1,716 words) - 11:48, 25 May 2025
  • Fibroblast growth factors (FGF) are a family of cell signalling proteins produced by the macrophages. They are involved in a wide variety of processes...
    25 KB (3,126 words) - 10:38, 23 January 2025
  • growth factor receptors consist of an extracellular ligand domain composed of three immunoglobulin-like domains, a single transmembrane helix domain,...
    8 KB (827 words) - 14:53, 16 April 2025
  • Transforming growth factor beta (TGFβ) receptors are single pass serine/threonine kinase receptors that belong to TGFβ receptor family. They exist in...
    4 KB (334 words) - 01:11, 14 December 2022
  • Thumbnail for Epidermal growth factor receptor
    epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family...
    60 KB (6,879 words) - 01:06, 1 March 2025
  • Thumbnail for Discoidin domain
    Discoidin domain (also known as F5/8 type C domain, or C2-like domain) is major protein domain of many blood coagulation factors. Blood coagulation factors V...
    6 KB (723 words) - 07:51, 27 August 2021
  • Thumbnail for Fibrillin-1
    repeating domains of epidermal growth factor (EGF)-like modules. These domains are homologous to calcium binding epidermal growth factor module (cbEGF-like motifs)...
    29 KB (3,496 words) - 05:07, 30 September 2024
  • Thumbnail for Platelet-derived growth factor receptor
    Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet-derived growth factor (PDGF) family...
    13 KB (1,563 words) - 09:00, 13 March 2024
  • Thumbnail for Insulin-like growth factor 1 receptor
    The insulin-like growth factor 1 (IGF-1) receptor is a protein found on the surface of human cells. It is a transmembrane receptor that is activated by...
    29 KB (3,603 words) - 16:26, 25 May 2024
  • Thumbnail for IGFBP3
    Insulin-like growth factor-binding protein 3, also known as IGFBP-3, is a protein that in humans is encoded by the IGFBP3 gene. IGFBP-3 is one of six IGF...
    39 KB (4,717 words) - 13:09, 2 June 2024
  • Thumbnail for Neuregulin
    H, et al. (August 1994). "Solution structure of the epidermal growth factor-like domain of heregulin-alpha, a ligand for p180erbB-4". EMBO J. 13 (15):...
    8 KB (867 words) - 10:27, 22 May 2025
  • Thumbnail for Fibroblast growth factor receptor 4
    Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334 (cluster...
    10 KB (1,291 words) - 09:08, 15 July 2024
  • Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells...
    40 KB (4,578 words) - 12:30, 10 September 2024
  • Thumbnail for Placental growth factor
    Placental growth factor (PlGF) is a protein that in humans is encoded by the PGF gene. Placental growth factor is a member of the VEGF (vascular endothelial...
    15 KB (1,867 words) - 09:38, 20 April 2025
  • Thumbnail for Platelet-derived growth factor
    Platelet-derived growth factor (PDGF) is one among numerous growth factors that regulate cell growth and division. In particular, PDGF plays a significant...
    24 KB (2,882 words) - 15:04, 24 May 2025
  • Thumbnail for Transforming growth factor beta
    Transforming growth factor beta (TGF-β) is a multifunctional cytokine belonging to the transforming growth factor superfamily that includes three different...
    67 KB (8,184 words) - 04:37, 2 June 2025
  • Thumbnail for L-selectin
    structural regions: an N-terminus C-type lectin domain, an adjacent epidermal growth factor-like domain, two to the consensus repeat units homologous to...
    22 KB (2,808 words) - 05:54, 17 March 2025