Imidazoline receptors are the primary receptors on which clonidine and other imidazolines act. There are three main classes of imidazoline receptor: I1...

it is now known that clonidine binds to imidazoline receptors with a much greater affinity than α2 receptors, which would account for its applications...

Rilmenidine is a imidazoline analog and shows greater selectivity for imidazoline receptors than for cerebral alpha2-adrenergic receptors, distinguishing...

is encoded by the NISCH gene. This gene encodes a nonadrenergic imidazoline-1 receptor protein that localizes to the inner layer of the plasma membrane...

2-Imidazoline (Preferred IUPAC name: 4,5-dihydro-1H-imidazole) is one of three isomers of the nitrogen-containing heterocycle imidazoline, with the formula...

1016/S0022-3565(24)37390-2. PMID 9536007. Reis DJ, Piletz JE (1997). "The imidazoline receptor in control of blood pressure by clonidine and drugs". American Journal...

Moxonidine (INN) is a new-generation alpha-2/imidazoline receptor agonist antihypertensive drug licensed for the treatment of mild to moderate essential...

Catecholamines Cholinergic agonists and antagonists Heteroreceptor Imidazoline receptor Neuromuscular transmission Synaptic transmission Levitan, Irwin B...

of pharmacological activities, including DNA mutagenic effects, imidazoline receptor interactions, serotonin reuptake inhibition, monoamine oxidase inhibition...

hormone receptors are found in the nucleus, cytosol, and also on the plasma membrane of target cells. They are generally intracellular receptors (typically...

ATC code C02 Antihypertensives is a therapeutic subgroup of the Anatomical Therapeutic Chemical Classification System, a system of alphanumeric codes developed...

their primary neurotransmitter, receptor or method of action. Many drugs act on more than one transmitter or receptor in the brain. Psychoactive drugs...

Efaroxan is an α2-adrenergic receptor antagonist and antagonist of the imidazoline receptor. The Darzens reaction between 2-fluorobenzaldehyde [57848-46-1]...

It acts as both a selective α2-adrenergic receptor antagonist, and an antagonist for the imidazoline receptor. Idazoxan has been under investigation as...

Tolonidine is an antihypertensive. It is an imidazoline receptor agonist, like moxonidine and rilmenidine. Clonidine Cosnier, D.; Duchene-Marullaz, P.;...

or placenta). Within those two classes are five types according to the receptors to which they bind: glucocorticoids and mineralocorticoids (both corticosteroids)...

In the field of molecular biology, nuclear receptors are a class of proteins responsible for sensing steroids, thyroid hormones, vitamins, and certain...

α2A-adrenergic receptor but also α2B- and α2C-adrenergic receptors and the imidazoline receptor. It is weaker than clonidine in producing hypotension and sedation...

pargyline has been found to bind with high affinity to the I2 imidazoline receptor. This receptor has been found to actually be an allosteric site on the monoamine...

candidate with a novel mechanism of action, acting as a ligand for the imidazoline receptor I2. It showed promising results in animal studies against various...

agmatinase. Agmatine binds to α2-adrenergic receptor and imidazoline receptor binding sites, and blocks NMDA receptors and other cation ligand-gated channels...

examples are: Brimonidine Clonidine (mixed alpha2-adrenergic and imidazoline-I1 receptor agonist) Dexmedetomidine Fadolmidine Guanfacine, (preference for...

effects appear on α adrenergic receptors, with little if any effect on β adrenergic receptors. Like other imidazolines, Oxymetazoline is readily absorbed...

acetylcholine receptor modulators Others: Imidazoline receptor modulators Purine receptor modulators Sigma receptor modulators Thyroid hormone receptor modulators...

bind with high affinity to the σ1 receptor (Ki = 3.2 nM) and with very high affinity to the I2 imidazoline receptor (Ki = 40 pM). Unlike selegiline, clorgiline...

RAR-related orphan receptor gamma (RORγ) is a protein that in humans is encoded by the RORC (RAR-related orphan receptor C) gene. RORγ is a member of...

well-studied α2-adrenergic receptor antagonist in its structural family which does not antagonize any variant of the imidazoline receptor. It was shown to possess...

used in glaucoma therapy. It is an α2 adrenergic receptor agonist and a weak α1 adrenergic receptor agonist.[citation needed] Topical apraclonidine is...

reversal by ketanserin. Harmine has also shown affinity for the imidazoline I2 receptor (Ki = 10 nM). It has been suggested that this action might be involved...

is a guanidine that activates presynaptic imidazoline receptors. Through its agonism at imidazoline receptors, aganodine inhibits the presynaptic release...