Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel activated by inositol trisphosphate (InsP3). InsP3R...
11 KB (1,115 words) - 13:40, 29 May 2024
Inositol trisphosphate or inositol 1,4,5-trisphosphate abbreviated InsP3 or Ins3P or IP3 is an inositol phosphate signaling molecule. It is made by hydrolysis...
19 KB (2,056 words) - 16:29, 7 September 2024
regulate ryanodine receptor. For example: dimerized Homer physical tether linking inositol trisphosphate receptors (IP3R) and ryanodine receptors on the intracellular...
25 KB (2,675 words) - 20:15, 23 May 2025
Phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3), abbreviated PIP3, is the product of the class I phosphoinositide 3-kinases' (PI 3-kinases)...
8 KB (779 words) - 21:05, 19 May 2024
the inositol ring. inositol monophosphate (IP) inositol bisphosphate (IP2) inositol trisphosphate (IP3) inositol tetrakisphosphate (IP4) inositol pentakisphosphate...
5 KB (516 words) - 18:43, 26 March 2024
Inositol (1,4,5) trisphosphate 3-kinase (EC 2.7.1.127), abbreviated here as ITP3K, is an enzyme that facilitates a phospho-group transfer from adenosine...
25 KB (2,891 words) - 06:48, 23 September 2024
intracellular calcium stores through activation of inositol trisphosphate receptors and ryanodine receptors". The Journal of Biological Chemistry. 281 (52):...
39 KB (4,039 words) - 18:45, 8 June 2025
Ligand-gated ion channel (redirect from Ionotropic receptor)
Voltage-dependent calcium channel Receptor (biochemistry) Inositol trisphosphate receptor Metabotropic receptor Ryanodine receptor "Gene Family: Ligand gated...
29 KB (2,607 words) - 05:16, 26 May 2025
Inositol 1,4,5-trisphosphate receptor, type 3, also known as ITPR3, is a protein which in humans is encoded by the ITPR3 gene. The protein encoded by...
8 KB (1,057 words) - 11:39, 17 January 2024
into two second messengers: inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG). IP3 binds with the IP3 receptor in the membrane of the smooth...
82 KB (9,408 words) - 20:56, 26 June 2025
Inositol 1,4,5-trisphosphate receptor, type 2, also known as ITPR2, is a protein which in humans is encoded by the ITPR2 gene. The protein encoded by...
8 KB (973 words) - 08:36, 29 April 2025
(FKBP12)-binding site on different isoforms of the ryanodine receptor and of the inositol 1,4,5-trisphosphate receptor". The Biochemical Journal. 354 (Pt 2): 413–22...
11 KB (1,344 words) - 03:32, 4 September 2024
inwardly rectifying K+ channels, ryanodine-inositol 1,4,5-triphosphate receptor Ca2+ channels, transient receptor potential Ca2+ channels, polycystin cation...
21 KB (2,298 words) - 09:52, 22 May 2025
Calcium channel (redirect from Receptor-operated calcium channel)
charged ions including calcium to pass through. These include P2X receptors, Transient Receptor Potential (TRP) channels, Cyclic nucleotide-gated (CNG) channels...
10 KB (760 words) - 05:44, 26 May 2025
phosphatidylinositol 4,5-bisphosphate (PIP2), which in turn causes an increase in inositol trisphosphate (IP3) and diacylglycerol (DAG). The former interacts with calcium...
33 KB (2,983 words) - 09:03, 18 May 2025
inositol trisphosphate receptor, and a reduction of ankyrin-B in neonatal cardiomyocytes reduces the half-life of the inositol trisphosphate receptor...
30 KB (3,443 words) - 14:40, 17 December 2024
Transient receptor potential channels (TRP channels) are a group of ion channels located mostly on the plasma membrane of numerous animal cell types. Most...
50 KB (5,540 words) - 19:53, 9 June 2025
nervous system. The H1 receptor is linked to an intracellular G-protein (Gq) that activates phospholipase C and the inositol triphosphate (IP3) signalling...
15 KB (1,745 words) - 20:38, 6 January 2025
phosphatidylinositol (3,4,5)-trisphosphate secondary messengers; Phospholipase C (PLC) which when activated is responsible for forming Inositol trisphosphate (IP3) and diacylglycerol...
11 KB (879 words) - 12:45, 14 May 2023
Phosphatidylinositol (redirect from Phosphatidyl inositol)
Phosphatidylinositol or inositol phospholipid is a biomolecule. It was initially called "inosite" when it was discovered by Léon Maquenne and Johann Joseph...
20 KB (2,019 words) - 22:54, 22 May 2025
GMP (cGMP), inositol 1,4,5-trisphosphate (IP3) and the calcium (Ca2+)-calmodulin system. Steroid hormone receptors and related receptors are generally...
17 KB (2,015 words) - 03:11, 30 January 2025
expressing Gi2. Coupling of the receptors to this protein mediates inositol trisphosphate signaling. A number of human V1 receptor homologues have also been...
7 KB (791 words) - 16:41, 3 May 2022
M1 muscarinic receptor, M3 receptors are G proteins of class Gq that upregulate phospholipase C and, therefore, inositol trisphosphate and intracellular...
36 KB (3,165 words) - 11:51, 25 May 2025
phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible...
22 KB (2,226 words) - 22:59, 25 May 2025
Caffeine (category Adenosine receptor antagonists)
adenosine receptors, caffeine is an inositol trisphosphate receptor 1 antagonist and a voltage-independent activator of the ryanodine receptors (RYR1, RYR2...
199 KB (19,546 words) - 23:05, 21 June 2025
TRPV1 (redirect from Vanilloid receptor subtype 1)
transient receptor potential cation channel subfamily V member 1 (TRPV1), also known as the capsaicin receptor and the vanilloid receptor 1, is a protein...
57 KB (6,748 words) - 02:46, 2 June 2025
Inositol 1,4,5-trisphosphate receptor type 1 is a protein that in humans is encoded by the ITPR1 gene. ITPR1 has been shown to interact with: AHCYL1,...
14 KB (1,718 words) - 22:42, 16 July 2024
Gq alpha subunit (section Receptors)
phosphatidylinositol 4,5-bisphosphate (PIP2) to diacyl glycerol (DAG) and inositol trisphosphate (IP3). IP3 acts as a second messenger to release stored calcium...
11 KB (1,092 words) - 04:32, 26 May 2025
voltages. When vagally-released acetylcholine (ACh) binds to muscarinic M2 receptors, this promotes dissociation of βγ subunit complexes, leading to direct...
10 KB (1,198 words) - 02:53, 16 June 2025
the inositol trisphosphate receptor. ITPKB produces Ins(1,3,4,5)P4, which does not gate the inositol trisphosphate receptor. The enzyme specifically phosphorylates...
3 KB (359 words) - 10:31, 22 December 2023