Integrin-linked kinase is an enzyme that in humans is encoded by the ILK gene involved with integrin-mediated signal transduction. Mutations in ILK are...
22 KB (2,662 words) - 16:37, 11 June 2025
"Integrin alphaVbeta3 contains a cell surface receptor site for thyroid hormone that is linked to activation of mitogen-activated protein kinase and...
36 KB (3,928 words) - 22:54, 6 February 2025
Signal transduction (category Commons category link is on Wikidata)
molecules, the main coordinator being integrin-linked kinase. As shown in the adjacent picture, cooperative integrin-RTK signaling determines the timing...
62 KB (7,645 words) - 05:36, 2 June 2025
Integrin-linked kinase-associated serine/threonine phosphatase 2C is an enzyme that in humans is encoded by the ILKAP gene. The protein encoded by this...
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although other molecules, including integrin-linked kinase (ILK) and mitogen-activated protein kinase-activated protein kinase-2 (MAPKAPK2) can also serve as...
35 KB (3,831 words) - 20:54, 25 May 2025
mediates cell survival in vitro via interaction with integrin beta 1 and activation of integrin-linked kinase. J. Biol. Chem. doi:10.1074/jbc.M706563200...
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AKT1 (category Protein kinases)
"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad...
24 KB (2,818 words) - 09:21, 25 January 2025
ILK or Ilk may refer to: Integrin-linked kinase, protein-coding gene in the species Homo sapiens ilk, the ISO 639-3 code for Bugkalot language Ilkley railway...
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thought to act as a bridge linking integrin-linked kinase to NCK adaptor protein 2, which is involved in growth factor receptor kinase signaling pathways. Its...
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2001). "Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase: critical roles for kinase activity and amino acids arginine...
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Andersson T, Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl-mediated ubiquitination in adherent human...
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PMID 10591208. Yamaji S, Suzuki A, Sugiyama Y, et al. (2001). "A novel integrin-linked kinase-binding protein, affixin, is involved in the early stage of cell-substrate...
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of integrins participating in latent TGF-β1 activation arose from studies that examined mutations/knockouts of β6 integrin, αV integrin, β8 integrin and...
67 KB (8,184 words) - 21:42, 19 June 2025
et al. (2001). "A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". J. Cell Biol. 153 (3):...
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the interaction of the cell wall and plant cells. Integrin-like receptors and integrin-linked kinases together have been implicated in surface adhesion...
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kinase 2 (PDK2), integrin-linked kinase (ILK), mechanistic target of rapamycin complex complex 2 (mTORC2) and DNA-dependent protein kinase (DNA-PK)...
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PTK2 (redirect from PTK2 protein tyrosine kinase 2)
Parsons JT (September 1995). "Focal adhesion kinase and paxillin bind to peptides mimicking beta integrin cytoplasmic domains". The Journal of Cell Biology...
41 KB (4,671 words) - 17:32, 10 June 2025
"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. Natl. Acad...
13 KB (1,519 words) - 06:00, 30 November 2024
"The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells". Molecular and Cellular...
13 KB (1,551 words) - 21:15, 3 March 2023
Housekeeping gene (section Casein kinase)
differentially imprinted GNAI2 HAX1 associated with tyrosine kinases ILK Integrin linked kinase MAPKAPK2 MAP2K2 MAP3K11 PITPNM Phosphatidylinositol transfer...
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with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha...
22 KB (2,600 words) - 22:18, 2 April 2024
(MeSH) Srivastava, D.; Yu, S (2006). "Stretching to meet needs: integrin-linked kinase and the cardiac pump". Genes Dev. 20 (17): 2327–2331. doi:10.1101/gad...
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biogenesis. Rho family GTPases, integrin linked kinase and focal adhesion kinase (FAK) activate cyclin D gene in response to integrin. p27Kip1 and p21cip1 are...
39 KB (4,605 words) - 19:08, 12 April 2025
PAK1 (redirect from P21/Cdc42/Rac1-activated kinase 1)
endothelial-cadherin-S665, poly(RC) binding protein 1-T60-S246, integrin-linked kinase 1-T173-S246, epithelium-specific Ets transcription factor 1-S207...
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mechanisms governing the termination of liver regeneration, involving integrin-linked kinase (ILK) and pericellular proteins like Glypican 3 (GPC3), are highly...
25 KB (2,734 words) - 13:16, 28 June 2024
Arrhythmogenic cardiomyopathy (category Commons category link is on Wikidata)
Liedtke D, Oh T, et al. (June 2019). "Mutations in ILK, encoding integrin-linked kinase, are associated with arrhythmogenic cardiomyopathy". Translational...
50 KB (5,442 words) - 13:30, 9 June 2025
LIM domain (section LIM kinases)
erythrocyte antigens. It can bind to ankyrin repeat domains of integrin-linked kinase. Also, LIM domain 4 of PINCH can bind to Nck2 protein to act as...
17 KB (1,963 words) - 00:38, 16 May 2025
In molecular biology, CD18 (Integrin beta chain-2) is an integrin beta chain protein that is encoded by the ITGB2 gene in humans. Upon binding with one...
11 KB (1,299 words) - 10:15, 11 December 2023
MAPK/ERK pathway (redirect from Ras/Raf/MAP kinase)
Myc. This process is described in more detail below. Receptor-linked tyrosine kinases, such as the epidermal growth factor receptor (EGFR), are activated...
24 KB (3,066 words) - 14:18, 3 June 2025
AKT2 (category Protein kinases)
"Phosphoinositide-3-OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proceedings of the...
13 KB (1,538 words) - 09:28, 24 April 2025