LY294002 is a morpholine-containing chemical compound that is a potent inhibitor of numerous proteins, and a strong inhibitor of phosphoinositide 3-kinases...
6 KB (442 words) - 06:19, 2 April 2024
and LY294002, although certain members of the class II PI3K family show decreased sensitivity. Wortmannin shows better efficiency than LY294002 on the...
32 KB (3,463 words) - 17:34, 20 November 2023
WORTMANNIN, LY294002, QUERCETIN, MYRICETIN AND STAUROSPORINE 1e7v: STRUCTURE DETERMINANTS OF PHOSPHOINOSITIDE 3-KINASE INHIBITION BY WORTMANNIN, LY294002, QUERCETIN...
5 KB (571 words) - 02:20, 23 December 2023
concentration (IC50) of around 5 nM, making it a more potent inhibitor than LY294002, another commonly used PI3K inhibitor. It displays a similar potency in...
12 KB (1,138 words) - 05:28, 7 May 2024
3-kinases are inhibited by the drugs wortmannin and LY294002 but wortmannin shows better efficiency than LY294002 on the hotspot mutation positions. In September...
17 KB (1,929 words) - 02:08, 3 December 2023
mostly conferred via the PI3K pathway because this pathway inhibitor (LY294002) completely blocks OXA effects in adipocytes. The link between OXA and...
54 KB (6,129 words) - 07:14, 8 May 2024
Hedgehog-Gli1 inhibitor arsenic trioxide and phosphoinositide 3-kinase inhibitor LY294002. OncoTargets and therapy. 2015;8:877. Han JB, Sang F, Chang JJ, Hua YQ...
27 KB (3,864 words) - 01:11, 4 December 2023
differentiation of oligodendrocyte progenitor cells.: 4.1 RVX-208 ABBV-744 LY294002 (some PI3K and BRD2, BRD3, and BRD4) AZD5153 MT-1 MS645 Bromodomain...
21 KB (2,514 words) - 21:48, 2 December 2023
SF1126 is a peptidic prodrug targeting integrin receptors that converts to LY294002, one of the most widely studied dual PI3K/mTOR inhibitors. A phase II trial...
44 KB (5,305 words) - 21:36, 24 March 2024
structures reveal the mechanism of serine/threonine kinase inhibition by LY294002". J Biol Chem. 280 (14): 13728–13734. doi:10.1074/jbc.M413155200. PMID 15657054...
13 KB (1,312 words) - 14:58, 6 June 2024
Pim-1 bound to staurosporine 1yi3: Crystal Structure of Pim-1 bound to LY294002 1yi4: Structure of Pim-1 bound to adenosine 1ywv: Crystal Structures of...
27 KB (2,973 words) - 10:50, 11 April 2024
important for efficient recruitment of Dock7 since the PI3K inhibitor LY294002 was shown to block Dock7-dependent functions in neurons. This observation...
9 KB (1,200 words) - 01:05, 22 June 2024
resistance to apoptosis, whereas treatment of cells with the PI3K inhibitor LY294002 decreased CUX1 expression and increased apoptosis. Whether the discrepancies...
37 KB (4,649 words) - 00:50, 11 June 2023
"Structural determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin, and staurosporine". Molecular Cell. 6 (4): 909–19...
11 KB (1,059 words) - 13:35, 10 June 2024
"Structural Determinants of Phosphoinositide 3-Kinase Inhibition by Wortmannin, LY294002, Quercetin, Myricetin, and Staurosporine". Molecular Cell. 6 (4): 909–919...
7 KB (540 words) - 23:41, 14 August 2023