• Thumbnail for Leukemia inhibitory factor
    Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the...
    13 KB (1,583 words) - 04:50, 17 August 2024
  • Thumbnail for Leukemia inhibitory factor receptor
    Differentiation 118), is a subunit of a receptor for leukemia inhibitory factor. The leukemia inhibitory factor (LIF) is a polyfunctional cytokine that...
    11 KB (1,325 words) - 16:37, 6 April 2024
  • unknown. The CNTF family of neurotrophic factors includes ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), interleukin-6 (IL-6), prolactin...
    16 KB (1,784 words) - 04:08, 6 January 2024
  • Thumbnail for Oncostatin M
    group of cytokines. Of these cytokines it most closely resembles leukemia inhibitory factor (LIF) in both structure and function. As yet poorly defined, it...
    32 KB (4,317 words) - 12:20, 2 November 2024
  • Thumbnail for Cytokine receptor
    throughout several cells and tissues of the vertebrate body Tumor necrosis factor receptor family, whose members share a cysteine-rich common extracellular binding...
    6 KB (442 words) - 18:18, 21 May 2025
  • IL-6 receptor IL-11 receptor IL-12 receptor IL-27 receptor Leukemia inhibitory factor receptor Oncostatin M receptor Type I cytokine receptors include...
    5 KB (514 words) - 21:40, 3 October 2024
  • Thumbnail for Oncostatin M receptor
    regulates the synthesis and turnover of gp130, leukemia inhibitory factor receptor alpha, and oncostatin M receptor beta by distinct mechanisms". The Journal...
    13 KB (1,631 words) - 10:14, 17 October 2022
  • Thumbnail for Brain-derived neurotrophic factor
    phosphorylation normally activates receptors, GABA is the brain's primary inhibitory neurotransmitter and phosphorylation of GABAA receptors tend to reduce their activity...
    50 KB (5,881 words) - 13:31, 5 May 2025
  • Thumbnail for Glycoprotein 130
    Glycoprotein 130 (category Type I cytokine receptors)
    been shown to interact with: Grb2, HER2/neu, Janus kinase 1 Leukemia inhibitory factor receptor, PTPN11, SHC1, SOCS3, and TLE1. GRCh38: Ensembl release 89:...
    20 KB (2,477 words) - 01:52, 14 June 2025
  • Thumbnail for STAT3
    STAT3 (category Transcription factors)
    connection between the PTEN-Akt-FOXO axis (suppressive) and the leukemia inhibitory factor receptor beta (LIFRbeta)-STAT3 signaling pathway (oncogenic) was shown...
    29 KB (3,485 words) - 06:51, 2 June 2025
  • Thumbnail for Erythropoietin receptor
    Higuchi M, Ohno R (February 2002). "Erythropoietin receptor in myelodysplastic syndrome and leukemia". Leukemia & Lymphoma. 43 (2): 261–264. doi:10.1080/10428190290006026...
    29 KB (3,348 words) - 06:59, 2 June 2025
  • Thumbnail for Hepatocyte growth factor receptor
    Hepatocyte growth factor receptor (HGF receptor) is a protein that in humans is encoded by the MET gene. The protein possesses tyrosine kinase activity...
    59 KB (6,731 words) - 05:32, 23 May 2025
  • Thumbnail for Granulocyte colony-stimulating factor
    People who have been administered colony-stimulating factors do not have a higher risk of leukemia than people who have not. G-CSF may also be given to...
    33 KB (3,830 words) - 21:00, 29 May 2025
  • Thumbnail for Nerve growth factor
    This pathway begins with the Trk receptor complex-recruitment of a second adaptor protein called growth factor-receptor bound protein-2 (Grb2) along with...
    27 KB (3,118 words) - 21:39, 29 May 2025
  • Thumbnail for Insulin-like growth factor 1
    growth factor (IGF) system. This system consists of three ligands (insulin, IGF-1 and IGF-2), two tyrosine kinase receptors (insulin receptor and IGF-1R...
    34 KB (4,517 words) - 04:19, 9 June 2025
  • Thumbnail for Epidermal growth factor receptor
    growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members of the epidermal growth factor family...
    60 KB (6,879 words) - 01:06, 1 March 2025
  • motility factor Bone morphogenetic proteins (BMPs) Ciliary neurotrophic factor family Ciliary neurotrophic factor (CNTF) Leukemia inhibitory factor (LIF)...
    10 KB (1,131 words) - 18:45, 6 May 2025
  • cells. KIRs are paired receptors, meaning some have activating and others have inhibitory functions; most KIRs are inhibitory: their recognition of MHC...
    36 KB (4,273 words) - 14:29, 24 May 2025
  • Thumbnail for Fibroblast growth factor 2
    specific fibroblast growth factor receptor (FGFR) proteins, themselves a family of closely related molecules. Fibroblast growth factor protein was first purified...
    22 KB (2,698 words) - 15:56, 25 May 2025
  • Thumbnail for Insulin-like growth factor
    distinct tissue types express the IGF-1 receptor, IGF-1's effects are diverse. It acts as a neurotrophic factor, inducing the survival of neurons. It may...
    14 KB (1,689 words) - 01:31, 19 August 2024
  • growth factor receptors (FGFRs). FGF1 is also known as acidic fibroblast growth factor, and FGF2 is also known as basic fibroblast growth factor. Members...
    25 KB (3,126 words) - 16:03, 10 June 2025
  • receptor - B cell receptor (BCR) Subunits- Immunoglobulin heavy chain / Immunoglobulin light chain Co-receptors Stimulatory CD21 CD19 CD81 Inhibitory...
    38 KB (2,656 words) - 20:26, 6 November 2024
  • Thumbnail for Granulocyte colony-stimulating factor receptor
    The granulocyte colony-stimulating factor receptor (G-CSF-R) also known as CD114 (Cluster of Differentiation 114) is a protein that in humans is encoded...
    13 KB (1,548 words) - 05:32, 17 August 2024
  • Thumbnail for Fibroblast growth factor receptor 1
    Fibroblast growth factor receptor 1 (FGFR-1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome...
    44 KB (5,003 words) - 14:24, 24 February 2025
  • family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor receptor (EGFR), its first discovered member...
    24 KB (2,736 words) - 16:03, 20 February 2025
  • NA, Hilton DJ, Ernst M (August 1997). "Distinct roles for leukemia inhibitory factor receptor alpha-chain and gp130 in cell type-specific signal transduction"...
    21 KB (2,717 words) - 01:53, 18 December 2024
  • Thumbnail for Granulocyte-macrophage colony-stimulating factor
    a granulocyte colony-stimulating factor (G-CSF) analog) Granulocyte-macrophage colony-stimulating factor receptor Lenzilumab Pegfilgrastim (Neulasta...
    17 KB (1,680 words) - 21:00, 29 May 2025
  • Thumbnail for Promyelocytic leukemia protein
    transcription factor partners, including the PML-retinoic acid receptor alpha oncoprotein found in human acute promyelocytic leukemia". Molecular and...
    33 KB (4,053 words) - 07:02, 10 July 2024
  • F, et al. (2003). "Vascular endothelial growth factor and its receptors in multiple myeloma". Leukemia. 17 (10): 1961–6. doi:10.1038/sj.leu.2403076. PMID 14513045...
    40 KB (4,578 words) - 12:30, 10 September 2024
  • TrkB receptors are expressed in most of these hippocampal neurons, including dentate granule cells, CA3 and CA1 pyramidal cells, and inhibitory interneurons...
    27 KB (3,130 words) - 22:26, 29 May 2025