• Thumbnail for Negative elongation factor
    biology, the NELF (negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription...
    10 KB (990 words) - 13:17, 27 September 2023
  • Thumbnail for P-TEFb
    that can phosphorylate the DRB sensitivity inducing factor (DSIF) and negative elongation factor (NELF), as well as the carboxyl terminal domain of the...
    10 KB (1,397 words) - 12:01, 17 October 2024
  • Thumbnail for Cofactor of BRCA1
    is a human gene that encodes NELF-B. NELF-B is a subunit of negative elongation factor (NELF), which also includes NELF-A (WHSC2; MIM 606026), either...
    11 KB (1,463 words) - 17:54, 20 November 2023
  • activity in producing mRNA. P-TEFb can also phosphorylate the negative elongation factor NELF (which pauses RNAP II within 60 nucleotides after mRNA initiation...
    34 KB (3,549 words) - 00:09, 27 December 2024
  • Thumbnail for Eukaryotic transcription
    sensitivity inducing factor), NELF (negative elongation factor), and the Drosophila RNA polymerase II transcription elongation complex". Proceedings...
    49 KB (5,867 words) - 10:43, 1 February 2025
  • Thumbnail for DSIF
    transcription by RNA polymerase II (Pol II). It can interact with the negative elongation factor (NELF) to promote the stalling of Pol II at some genes, which...
    7 KB (746 words) - 07:37, 28 October 2024
  • Thumbnail for RDBP
    Negative elongation factor E is a protein that in humans is encoded by the RDBP gene. The protein encoded by this gene is part of a complex termed negative...
    9 KB (1,207 words) - 04:46, 15 April 2024
  • Thumbnail for 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole
    transcription elongation by RNA Polymerase II. Sensitivity to DRB is dependent on DRB sensitivity inducing factor (DSIF), negative elongation factor (NELF),...
    3 KB (103 words) - 16:39, 23 December 2024
  • Thumbnail for WHSC2
    Negative elongation factor A is a protein that in humans is encoded by the WHSC2 gene. This gene is expressed ubiquitously with higher levels in fetal...
    8 KB (1,059 words) - 17:20, 12 August 2023
  • Thumbnail for SUPT5H
    Transcription elongation factor SPT5 is a protein that in humans is encoded by the SUPT5H gene. SUPT5H has been shown to interact with: CDK9, Cyclin-dependent...
    10 KB (1,231 words) - 02:49, 19 December 2023
  • accepted view was that sigma factor must dissociate upon transition from transcription initiation to transcription elongation (this transition is called...
    20 KB (2,045 words) - 23:47, 25 October 2024
  • Thumbnail for TH1L
    Negative elongation factor C/D is a protein that in humans is encoded by the TH1L gene. The NELF[clarification needed] complex of proteins interacts with...
    8 KB (1,032 words) - 01:19, 28 July 2024
  • Thumbnail for General transcription factor
    RNA elongation begins. TFIID will stay until elongation is finished. Subunits within TFIIH that have ATPase and helicase activity create negative superhelical...
    12 KB (1,317 words) - 16:05, 14 March 2025
  • LHRH factor, a protein encoded by the NELF gene Near East Land Forces, a former part of the British Near East Command Negative elongation factor, a protein...
    597 bytes (86 words) - 20:53, 29 June 2022
  • Thumbnail for Insulin-like growth factor 1
    Insulin-like growth factor 1 (IGF-1), also called somatomedin C, is a hormone similar in molecular structure to insulin which plays an important role in...
    34 KB (4,512 words) - 06:26, 2 May 2025
  • Thumbnail for Transcription (biology)
    transcription elongation. In these organisms, the pausing induced by nucleosomes can be regulated by transcription elongation factors such as TFIIS. Elongation also...
    58 KB (6,898 words) - 21:17, 23 March 2025
  • Thumbnail for Stress granule
    (2013). "Heat shock-induced accumulation of translation elongation and termination factors precedes assembly of stress granules in S. cerevisiae". PLOS...
    184 KB (12,563 words) - 05:08, 10 March 2025
  • Dreier B, Barbas CF (2000). "Positive and negative regulation of endogenous genes by designed transcription factors". Proc. Natl. Acad. Sci. U.S.A. 97 (4):...
    4 KB (561 words) - 07:13, 21 January 2024
  • Thumbnail for ELL3
    Elongation factor RNA polymerase II-like 3 is a protein that in humans is encoded by the ELL3 gene. GRCh38: Ensembl release 89: ENSG00000128886 – Ensembl...
    2 KB (276 words) - 19:42, 3 March 2023
  • Thumbnail for Gravitropism
    asymmetric expansion of cells in a shoot-ward region to the tip known as the elongation zone. Differential growth during tropisms mainly involves changes in cell...
    23 KB (2,797 words) - 16:23, 6 March 2025
  • Thumbnail for Transcription factor
    In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic...
    75 KB (8,348 words) - 20:03, 18 March 2025
  • Thumbnail for Estrogen receptor alpha
    Estrogen receptor alpha (category Transcription factors)
    alpha-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor". Genes & Development. 18 (17): 2134–2146. doi:10.1101/gad.1214104...
    58 KB (6,133 words) - 02:11, 17 March 2025
  • Thumbnail for Tension (physics)
    this context, tension is analogous to negative pressure. A rod under tension elongates. The amount of elongation and the load that will cause failure both...
    8 KB (1,203 words) - 10:05, 21 February 2025
  • Thumbnail for TCEA2
    Transcription elongation factor A protein 2 is a protein that in humans is encoded by the TCEA2 gene. The protein encoded by this gene is found in the...
    7 KB (950 words) - 10:54, 17 October 2022
  • Thumbnail for Circular chromosome
    subtilis. Chromosome replication proceeds in three major stages: initiation, elongation and termination. The initiation stage starts with the ordered assembly...
    21 KB (2,745 words) - 08:39, 17 November 2024
  • statements for the elongation at break : Research on alloys based on the purest shows an increasing elongation at break from about 20% elongation at 1% to 30%...
    19 KB (1,987 words) - 01:47, 24 November 2024
  • nuclear membrane prevents this coupling in eukaryotes. Eukaryotic elongation factor 2 (eEF2) is a regulateable GTP-dependent translocase that moves nascent...
    11 KB (1,481 words) - 11:25, 11 February 2024
  • Thumbnail for Pseudomonas exotoxin
    toxin (Q5EK40). It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease...
    3 KB (291 words) - 03:59, 9 June 2024
  • Thumbnail for SUPT4H1
    Transcription elongation factor SPT4 is a protein that in humans is encoded by the SUPT4H1 gene. GRCm38: Ensembl release 89: ENSMUSG00000020485 – Ensembl...
    7 KB (915 words) - 17:19, 12 May 2024
  • Thumbnail for Proteus mirabilis
    Proteus mirabilis (category Gram-negative bacteria)
    process into a swarmer cell. This differentiation process includes the elongation of the cell 20 to 50 times longer than the vegetative cell, multinucleation...
    12 KB (1,254 words) - 15:44, 30 April 2025