In organic chemistry, a nucleophilic addition (AN) reaction is an addition reaction where a chemical compound with an electrophilic double or triple bond...
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Nucleophilic conjugate addition is a type of organic reaction. Ordinary nucleophilic additions or 1,2-nucleophilic additions deal mostly with additions...
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Nucleophile (redirect from Nucleophilicity)
nucleophilic substitution, whereby a nucleophile becomes attracted to a full or partial positive charge, and nucleophilic addition. Nucleophilicity is...
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Ketone (section Nucleophilic additions)
carbonyl carbon toward nucleophilic addition and the tendency for the enolates to add to electrophiles. Nucleophilic additions include in approximate...
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Aldehyde (section Nucleophilic addition reactions)
acetylides, undergo nucleophilic addition reactions, yielding a substituted alcohol group. Related reactions include organostannane additions, Barbier reactions...
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polar addition reactions: electrophilic addition and nucleophilic addition. Two non-polar addition reactions exist as well, called free-radical addition and...
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the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. Organolithium reagents are used in industry...
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Aryne (section Nucleophilic additions to arynes)
syn-coplanar E2 mechanism. The resulting benzyne forms addition products, usually by nucleophilic addition and protonation. Generation of the benzyne intermediate...
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Green–Davies–Mingos rules (redirect from Addition to pi ligands)
chemistry, the Green–Davies–Mingos rules predict the regiochemistry for nucleophilic addition to 18-electron metal complexes containing multiple unsaturated ligands...
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models exist to describe chiral induction at carbonyl carbons during nucleophilic additions. These models are based on a combination of steric and electronic...
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Aromatic rings are usually nucleophilic, but some aromatic compounds do undergo nucleophilic substitution. Just as normally nucleophilic alkenes can be made...
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Isatin (section C-2/C-3 nucleophilic addition)
pyridinium bromide to form dibenzo[b,d]azepin-6-ones. Isatin suffers nucleophilic addition on carbonyls at C-2 and C-3 positions. The regioselectivity of the...
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atom or an organic substituent. They generally result from the nucleophilic addition of an alcohol (a compound with at least one hydroxy group) to an...
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formaldehyde is an exceptionally reactive electrophile it allows nucleophilic addition of hemiacetal intermediates, which are in general short-lived and...
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to form carbon–carbon bonds. In its usual form, it involves the nucleophilic addition of a ketone enolate to an aldehyde to form a β-hydroxy ketone, or...
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Chemical reaction (section Addition and elimination)
oxygen atom, whereas the bases enhance the nucleophilicity of the attacking nucleophile. Nucleophilic addition of a carbanion or another nucleophile to...
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named after Carl Mannich. The Mannich reaction starts with the nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff...
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1,3-Dipolar cycloaddition (redirect from 1,3-Dipolar addition)
scheme below). The polar reaction, N-cyclopentenyl pyrrolidine nucleophilic addition to the diazo compound, proceeds 1,500 times faster in polar DMSO...
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after Henry Drysdale Dakin. The Dakin oxidation starts with (1) nucleophilic addition of a hydroperoxide ion to the carbonyl carbon, forming a (2) tetrahedral...
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Arrow pushing (section Addition reactions)
site of nucleophilic addition. A 1,2-addition occurs with nucleophilic addition to position 2 while a 1,4-addition occurs with nucleophilic addition to position...
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Imine (section Nucleophilic additions)
aldehydes. In terms of mechanism, such reactions proceed via the nucleophilic addition giving a hemiaminal −C(OH)(NR2)− intermediate, followed by an elimination...
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anionic or cationic catalysts and heat, or copolymerised through nucleophilic addition reactions with multifunctional crosslinking agents which are also...
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aldehyde is the rate-limiting step leading to the carbenium ion 2. The nucleophilic addition of urea gives the intermediate 4, which quickly dehydrates to give...
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modification of the aldol condensation. A Knoevenagel condensation is a nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a...
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Therefore, with more electrophilic carbon, aldehydes allow for better nucleophilic addition to the carbon on the carbon-oxygen double bond. On the other hand...
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alkyl-modified carbon nanotubes. Hirsch was also able to show the nucleophilic addition of amines by generating lithium amides, leading to amino-modified...
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be prepared from triethylaluminium and HCN. It has been used in nucleophilic addition to ketones. For an example of its use see: Kuwajima Taxol total...
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and f-block metals, using many different synthetic routes such as nucleophilic addition and alpha-hydrogen abstraction. The term carbene ligand is a formalism...
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Aldol reaction (redirect from Aldol addition)
β-hydroxy carbonyl compound. Its simplest form might involve the nucleophilic addition of an enolized ketone to another: These products are known as aldols...
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Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary...
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