• In organic chemistry, a nucleophilic addition (AN) reaction is an addition reaction where a chemical compound with an electrophilic double or triple bond...
    8 KB (910 words) - 13:13, 26 August 2024
  • Thumbnail for Nucleophilic conjugate addition
    Nucleophilic conjugate addition is a type of organic reaction. Ordinary nucleophilic additions or 1,2-nucleophilic additions deal mostly with additions...
    6 KB (625 words) - 20:20, 5 March 2024
  • Nucleophile (redirect from Nucleophilicity)
    nucleophilic substitution, whereby a nucleophile becomes attracted to a full or partial positive charge, and nucleophilic addition. Nucleophilicity is...
    18 KB (2,191 words) - 18:59, 24 May 2025
  • Thumbnail for Ketone
    carbonyl carbon toward nucleophilic addition and the tendency for the enolates to add to electrophiles. Nucleophilic additions include in approximate...
    24 KB (2,895 words) - 18:04, 2 June 2025
  • Thumbnail for Aldehyde
    acetylides, undergo nucleophilic addition reactions, yielding a substituted alcohol group. Related reactions include organostannane additions, Barbier reactions...
    30 KB (3,112 words) - 13:18, 1 June 2025
  • Thumbnail for Addition reaction
    polar addition reactions: electrophilic addition and nucleophilic addition. Two non-polar addition reactions exist as well, called free-radical addition and...
    3 KB (365 words) - 13:38, 16 July 2024
  • Thumbnail for Organolithium reagent
    the lithium atom to the substrates in synthetic steps, through nucleophilic addition or simple deprotonation. Organolithium reagents are used in industry...
    55 KB (5,955 words) - 23:00, 13 March 2025
  • syn-coplanar E2 mechanism. The resulting benzyne forms addition products, usually by nucleophilic addition and protonation. Generation of the benzyne intermediate...
    28 KB (3,141 words) - 06:54, 2 June 2025
  • chemistry, the Green–Davies–Mingos rules predict the regiochemistry for nucleophilic addition to 18-electron metal complexes containing multiple unsaturated ligands...
    7 KB (792 words) - 11:53, 6 November 2024
  • Thumbnail for Asymmetric induction
    models exist to describe chiral induction at carbonyl carbons during nucleophilic additions. These models are based on a combination of steric and electronic...
    29 KB (3,695 words) - 13:28, 30 January 2025
  • Thumbnail for Nucleophilic aromatic substitution
    Aromatic rings are usually nucleophilic, but some aromatic compounds do undergo nucleophilic substitution. Just as normally nucleophilic alkenes can be made...
    11 KB (1,295 words) - 06:15, 27 December 2024
  • Thumbnail for Isatin
    pyridinium bromide to form dibenzo[b,d]azepin-6-ones. Isatin suffers nucleophilic addition on carbonyls at C-2 and C-3 positions. The regioselectivity of the...
    17 KB (1,619 words) - 20:51, 21 May 2025
  • Thumbnail for Hemiacetal
    atom or an organic substituent. They generally result from the nucleophilic addition of an alcohol (a compound with at least one hydroxy group) to an...
    9 KB (799 words) - 05:27, 26 May 2025
  • Thumbnail for Polymerization
    formaldehyde is an exceptionally reactive electrophile it allows nucleophilic addition of hemiacetal intermediates, which are in general short-lived and...
    14 KB (1,444 words) - 02:27, 25 May 2025
  • Thumbnail for Aldol condensation
    to form carbon–carbon bonds. In its usual form, it involves the nucleophilic addition of a ketone enolate to an aldehyde to form a β-hydroxy ketone, or...
    18 KB (1,816 words) - 18:28, 25 May 2025
  • Thumbnail for Chemical reaction
    oxygen atom, whereas the bases enhance the nucleophilicity of the attacking nucleophile. Nucleophilic addition of a carbanion or another nucleophile to...
    66 KB (8,057 words) - 20:26, 4 June 2025
  • named after Carl Mannich. The Mannich reaction starts with the nucleophilic addition of an amine to a carbonyl group followed by dehydration to the Schiff...
    10 KB (1,042 words) - 15:42, 2 June 2025
  • scheme below). The polar reaction, N-cyclopentenyl pyrrolidine nucleophilic addition to the diazo compound, proceeds 1,500 times faster in polar DMSO...
    65 KB (6,396 words) - 07:16, 24 May 2025
  • Thumbnail for Dakin oxidation
    after Henry Drysdale Dakin. The Dakin oxidation starts with (1) nucleophilic addition of a hydroperoxide ion to the carbonyl carbon, forming a (2) tetrahedral...
    15 KB (1,516 words) - 01:41, 25 May 2025
  • site of nucleophilic addition. A 1,2-addition occurs with nucleophilic addition to position 2 while a 1,4-addition occurs with nucleophilic addition to position...
    18 KB (2,084 words) - 12:14, 24 May 2025
  • Thumbnail for Imine
    aldehydes. In terms of mechanism, such reactions proceed via the nucleophilic addition giving a hemiaminal −C(OH)(NR2)− intermediate, followed by an elimination...
    24 KB (2,710 words) - 15:58, 26 May 2025
  • Thumbnail for Thermosetting polymer
    anionic or cationic catalysts and heat, or copolymerised through nucleophilic addition reactions with multifunctional crosslinking agents which are also...
    14 KB (1,744 words) - 16:00, 30 May 2025
  • Thumbnail for Biginelli reaction
    aldehyde is the rate-limiting step leading to the carbenium ion 2. The nucleophilic addition of urea gives the intermediate 4, which quickly dehydrates to give...
    10 KB (1,044 words) - 22:55, 1 August 2024
  • modification of the aldol condensation. A Knoevenagel condensation is a nucleophilic addition of an active hydrogen compound to a carbonyl group followed by a...
    7 KB (729 words) - 10:15, 12 February 2025
  • Thumbnail for Enolate
    Therefore, with more electrophilic carbon, aldehydes allow for better nucleophilic addition to the carbon on the carbon-oxygen double bond. On the other hand...
    21 KB (2,467 words) - 09:11, 19 May 2025
  • Thumbnail for Carbon nanotube chemistry
    alkyl-modified carbon nanotubes. Hirsch was also able to show the nucleophilic addition of amines by generating lithium amides, leading to amino-modified...
    34 KB (3,689 words) - 16:00, 23 May 2025
  • be prepared from triethylaluminium and HCN. It has been used in nucleophilic addition to ketones. For an example of its use see: Kuwajima Taxol total...
    32 KB (3,681 words) - 01:17, 20 May 2025
  • and f-block metals, using many different synthetic routes such as nucleophilic addition and alpha-hydrogen abstraction. The term carbene ligand is a formalism...
    20 KB (2,014 words) - 20:42, 22 May 2025
  • β-hydroxy carbonyl compound. Its simplest form might involve the nucleophilic addition of an enolized ketone to another: These products are known as aldols...
    40 KB (4,256 words) - 12:17, 6 June 2025
  • Mannich base is an endproduct in the Mannich reaction, which is nucleophilic addition reaction of a non-enolizable aldehyde and any primary or secondary...
    2 KB (223 words) - 20:34, 6 August 2020