Off-target activity is biological activity of a drug that is different from and not at that of its intended biological target. It most commonly contributes...

Off-target genome editing refers to nonspecific and unintended genetic modifications that can arise through the use of engineered nuclease technologies...

also reduce the activity of related proteins such as GDF11, activins, and bone morphogenetic proteins. While this off target activity can increase their...

In addition to its β-lactamase inhibition, clavulanic acid shows off-target activity in the nervous system by upregulating the glutamate transporter 1...

engineered variants of the Cas9 nuclease that significantly reduce off-target activity have been developed. CRISPR-Cas9 genome editing techniques have many...

antagonistic beta blocker in 1962. But pronethalol suffered from off-target activity and associated side effects and toxicity. As such, it did not enter...

other important hormonal activity. Because of its antimineralocorticoid activity and lack of undesirable off-target activity, drospirenone is said to...

epigenetic reprogramming. Therefore, drugs should be screened for off-target activity by gene expression profiling, in addition to conventional ligand...

theoretically yield less off-target activity. A comparison of a pair of 3-finger ZFNs and a pair of 4-finger ZFNs detected off-target cleavage in human cells...

In pharmacology, an antitarget (or off-target) is a receptor, enzyme, or other biological target that, when affected by a drug, causes undesirable side-effects...

selective activation of the biomolecules helps prevent or minimize off-target activity and systemic side effects. Moreover, light being the regulatory element...

Turkey as Pional. Metformin is a pleiotropic drug, with extensive off-target activity beyond its antidiabetic effect. Much of this has been attributed...

construction and testing of the proteins created for targeting each DNA sequence. Because off-target activity of an active nuclease would have potentially dangerous...

unclear and several competing hypotheses exist. Mefloquine has known off-target activities. This includes affinity for the serotonin 5-HT2A receptor and to...

reaction with glutathione. B-elimination reaction follows, resulting in off-target activity and a loss of efficacy of the drugs. No general method exist for...

genome in what constitutes dramatic off-target activity. It is therefore necessary for fusion constructs and targeting mechanisms to be optimized for reliable...

possess off-target actions including progestogenic, antimineralocorticoid, and/or glucocorticoid activity in addition to their antiandrogen activity, and...

high-affinity interactions with therapeutic targets, but they may also lead to undesirable off-target activity, and they may also be substrates of metabolic...

and TB-21007. Certain drugs show weak GABAA receptor NAM activity as an off-target activity that is responsible for undesirable side effects like anxiety...

history, purchase history, and other recent online activities. The process of algorithm targeting eliminates waste. Traditional forms of advertising,...

requirements, advantageous off-target activity, and allele-specific editing capabilities, which could broaden the range of targetable diseases in the genome...

range like CRISPR based genome editing[clarification needed]. The off-target activity of an active nuclease may lead to unwanted double-strand breaks and...

involves the establishment of a target start approval time (TSAT), target off block time (TOBT) and target take off time (TTOT) for each flight. Airport...

and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4): e0231716. Bibcode:2020PLoSO..1531716C. doi:10...

stability, and a favorable preliminary profile of off-target activity (≥1–10 μM at 42 other targets). It is far more potent (893-fold) as an antagonist...

the demon when the daughter, Leila, is targeted as she was born on the same date as Hunter from Paranormal Activity 2. Along with normal recorders, the family...

January 3, 2014, in the United States, it is spin-off and the fifth installment of the Paranormal Activity film series. It is also Landon's second directorial...

The history of Target Corporation first began in 1902 by George Dayton. The company was originally named Goodfellow Dry Goods in June 1902 before being...

President Trump during nationwide 'Hands Off!' rallies". www.wctv.tv. Retrieved April 6, 2025. "Hands Off! protests target Trump, Musk in Cocoa, DeLand, Daytona...

Gang (June 2014). "CRISPR/Cas9 systems have off-target activity with insertions or deletions between target DNA and guide RNA sequences". Nucleic Acids...