• In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes and archaea in...
    21 KB (2,339 words) - 22:38, 18 March 2025
  • Thumbnail for Origin of replication
    Zhao Y, et al. (July 2018). "Structure of the origin recognition complex bound to DNA replication origin". Nature. 559 (7713): 217–222. Bibcode:2018Natur...
    113 KB (12,563 words) - 21:58, 15 June 2025
  • Thumbnail for Eukaryotic DNA replication
    assembly of the pre-replication complex (pre-RC) is the binding of the origin recognition complex (ORC) to the replication origin. In late mitosis, the Cdc6...
    121 KB (14,916 words) - 04:06, 3 January 2025
  • Thumbnail for Pre-replication complex
    simplified model of the eukaryotic pre-RC. It is composed of a single origin recognition complex (ORC) protein, Cdc6/ORC1, and a homohexamer of the minichromosome...
    15 KB (1,928 words) - 17:24, 8 January 2024
  • Thumbnail for DNA replication
    associate with the bound origin recognition complex at the origin in order to form a larger complex necessary to load the Mcm complex onto the DNA. In eukaryotes...
    61 KB (7,458 words) - 14:41, 28 July 2025
  • Thumbnail for ORC6
    Origin recognition complex subunit 6 is a protein that in humans is encoded by the ORC6 (ORC6L) gene. The origin recognition complex (ORC) is a highly...
    9 KB (881 words) - 18:11, 16 July 2025
  • Thumbnail for ORC5
    Origin recognition complex subunit 5 is a protein that in humans is encoded by the ORC5 (ORC5L) gene. The origin recognition complex (ORC) is a highly...
    8 KB (983 words) - 18:11, 16 July 2025
  • union Organic Rankine Cycle Organized retail crime Origin recognition complex, a protein complex Otago Regional Council, New Zealand Ottawa Rowing Club...
    2 KB (266 words) - 18:38, 4 March 2025
  • Thumbnail for DNA unwinding element
    by origin recognition complex. DUEs are found in both prokaryotic and eukaryotic organisms, but were first discovered in yeast and bacteria origins, by...
    18 KB (2,304 words) - 09:30, 17 April 2025
  • Thumbnail for ORC1
    Origin recognition complex subunit 1 is a protein that in humans is encoded by the ORC1 gene. It is closely related to CDC6, and both are the same protein...
    12 KB (1,433 words) - 18:11, 16 July 2025
  • Thumbnail for ORC3
    Origin recognition complex subunit 3 is a protein that in humans is encoded by the ORC3 (ORC3L) gene. The origin recognition complex (ORC) is a highly...
    8 KB (974 words) - 04:33, 15 July 2025
  • proteins to disrupt the H-bonding in that area. ORC protein complex (origin recognition complex) is bound at the ARS throughout the cell cycle, allowing...
    2 KB (322 words) - 00:01, 20 April 2025
  • Thumbnail for Bik Kwoon Tye
    the first high-resolution structures of both the MCM complex and the Origin Recognition Complex (ORC) in 2015 and 2018. Tye is currently a Professor Emeritus...
    10 KB (1,154 words) - 22:10, 16 March 2025
  • Thumbnail for Cell cycle
    Cellular model Eukaryotic DNA replication Mitotic catastrophe Origin recognition complex Retinoblastoma protein Synchronous culture – synchronization of...
    78 KB (9,148 words) - 05:15, 29 July 2025
  • Thumbnail for DNA replication factor CDT1
    pre-replication complexes (pre-RC), which occurs during the G1 phase of the cell cycle. In the assembly of pre-RCs, origin recognition complexes (ORC1-6) recognize...
    12 KB (1,439 words) - 16:22, 17 July 2025
  • Thumbnail for Kinetochore
    Bub1, Bub3, Mad2 and CENP-E. Orc2 (a protein that belongs to the origin recognition complex -ORC- implicated in DNA replication initiation during S phase)...
    65 KB (7,863 words) - 17:23, 23 May 2025
  • Thumbnail for ORC4
    Origin recognition complex subunit 4 is a protein that in humans is encoded by the ORC4 (ORC4L) gene. The origin recognition complex (ORC) is a highly...
    9 KB (1,126 words) - 17:45, 17 July 2025
  • Thumbnail for ORC2
    Origin recognition complex subunit 2 is a protein that is encoded by the ORC2 (ORC2L) gene in humans. The origin recognition complex (ORC) is a highly...
    13 KB (1,480 words) - 06:48, 19 July 2025
  • Thumbnail for Replisome
    Efficient replisome assembly at origins of replication (origin recognition complexes or specific replication origin sequences in some organisms) Separating...
    32 KB (3,700 words) - 00:38, 1 January 2024
  • Thumbnail for Spindle checkpoint
    20-50kb. In this direction, Orc2 (one protein included in the origin recognition complex, ORC, implicated in the initiation of DNA replication during S...
    73 KB (9,173 words) - 03:18, 3 July 2025
  • Thumbnail for Anaphase-promoting complex
    protein that binds to Cdt1 which prevents its binding to the origin recognition complex (ORC). APCCdh1 targets geminin for ubiquitination throughout G1...
    31 KB (4,194 words) - 08:16, 24 June 2025
  • Thumbnail for Cold Spring Harbor Laboratory
    and elucidation of the mechanism of the Origin Recognition Complex (ORC), a highly conserved protein complex that recognizes and binds to specific DNA...
    38 KB (3,981 words) - 19:43, 24 May 2025
  • Thumbnail for DnaA
    unwinding of origin DNA for precise timing. DnaA recognition sites in Escherichia coli are arranged in OriC to facilitate staged pre-replication complex assembling...
    34 KB (4,283 words) - 13:04, 23 May 2025
  • Thumbnail for Meier-Gorlin syndrome
    of MGORS. Pre-replication complex is an important protein complex, which consist of 6 subunits of Origin Recognition Complex (ORC1, ORC2, ORC3, ORC4, ORC5...
    16 KB (1,472 words) - 04:42, 1 August 2025
  • Thumbnail for Minichromosome maintenance
    Site selection for replication origins is carried out by the Origin Recognition Complex (ORC), a six subunit complex (Orc1-6). During the G1 phase of...
    24 KB (3,046 words) - 09:28, 13 July 2025
  • Thumbnail for RRM3
    in Rrm3p code for a region that binds to Orc5, a domain in an origin recognition complex. The binding of these two proteins appears to be linked to inappropriate...
    16 KB (2,033 words) - 01:35, 3 December 2023
  • Thumbnail for Polytene chromosome
    with the active chromatin proteins, nucleosome remodeling, and origin recognition complexes. Their primary functions are: to act as binding sites for RNA...
    16 KB (1,980 words) - 01:45, 12 July 2025
  • Thumbnail for Non-coding RNA
    interactions with chromatin and initiation proteins (including the origin recognition complex). They are also components of the Ro60 ribonucleoprotein particle...
    67 KB (7,183 words) - 09:53, 18 July 2025
  • Thumbnail for ChIP-on-chip
    are transcription factors, replication-related proteins, like origin recognition complex protein (ORC), histones, their variants, and histone modifications...
    25 KB (3,057 words) - 05:34, 12 December 2023
  • also known as automatic speech recognition (ASR), computer speech recognition, or speech-to-text (STT). Speech recognition applications include voice user...
    121 KB (12,928 words) - 19:28, 2 August 2025