Proliferating cell nuclear antigen (redirect from PCNA)
antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. PCNA is a homotrimer...
55 KB (6,180 words) - 10:18, 9 May 2025
acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as of August 2023 for...
6 KB (589 words) - 19:43, 22 June 2025
both PCNA and RFC, and produces mostly ligated DNA products. It is also found that under one condition where DNA polymerase epsilon require PCNA and RFC:...
3 KB (336 words) - 03:59, 2 December 2024
P21 (section PCNA inhibition)
binding region on PCNA, binding of p21 to this region is proposed to block the binding of processivity factors necessary for PCNA dependent S-phase DNA...
34 KB (3,931 words) - 20:49, 22 May 2025
cell nuclear antigen (PCNA). Under normal circumstances, PCNA bound to polymerases replicates the DNA. At a site of lesion, PCNA is ubiquitinated, or modified...
132 KB (16,142 words) - 16:06, 11 June 2025
DNA mismatch repair (section PCNA β-sliding clamp)
(PCNA), in an orientation-specific manner, such that one face of the donut-shape protein is juxtaposed toward the 3'-OH end at the nick. Loaded PCNA then...
37 KB (4,466 words) - 20:37, 29 May 2025
proliferating cell nuclear antigen (PCNA). The N-terminal and C-terminal domains of PCNA are topologically identical. Three PCNA molecules are tightly associated...
23 KB (2,044 words) - 07:04, 10 March 2024
cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor C, through its role as the clamp loader for PCNA (which involves catalysing...
2 KB (259 words) - 21:21, 11 December 2023
A Ramachandran plot generated from human PCNA, a trimeric DNA clamp protein that contains both β-sheet and α-helix (PDB ID 1AXC). The red, brown, and yellow...
16 KB (1,761 words) - 16:42, 2 June 2025
antigen (PCNA). The PCNA ring has polarity with surfaces that interact with DNA polymerases and tethers them securely to the DNA template. PCNA-dependent...
121 KB (14,916 words) - 04:06, 3 January 2025
the other subunits that interact with Proliferating Cell Nuclear Antigen (PCNA), which is a DNA clamp that allows Pol δ to possess processivity. Pol ε is...
59 KB (7,110 words) - 11:07, 2 July 2025
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
29 KB (3,150 words) - 19:32, 18 June 2025
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
105 KB (11,400 words) - 20:04, 11 July 2025
by the FEN1 and it creates a functional continuous double strand of DNA. PCNA simulates enzymatic functions of proteins for both FEN1 and DNA ligase. The...
34 KB (4,470 words) - 07:49, 11 November 2024
shown to interact with: AURKA, Cdk1, CCNB1, GADD45GIP1 MAP3K4, P21, and PCNA. Gadd45 GRCh38: Ensembl release 89: ENSG00000116717 – Ensembl, May 2017 GRCm38:...
13 KB (1,576 words) - 21:43, 15 July 2025
Cynopa pyrrhogaster, this transition was shown to involve expression of PCNA, a DNA polymerase delta auxiliary protein involved in DNA replication and...
36 KB (3,837 words) - 21:39, 20 June 2025
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
38 KB (4,246 words) - 13:59, 17 January 2025
The assembled human DNA clamp, a trimer of the protein PCNA...
61 KB (7,454 words) - 05:22, 14 July 2025
Bittl JA, Byrne JG, Fletcher BJ, et al. (November 2014). "2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management...
109 KB (11,058 words) - 11:32, 28 June 2025
Wright JT (June 2018). "2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High...
136 KB (14,177 words) - 05:58, 13 July 2025
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
81 KB (8,730 words) - 02:42, 30 June 2025
The replisome is composed of a number of proteins including helicase, RFC, PCNA, gyrase/topoisomerase, SSB/RPA, primase, DNA polymerase III, RNAse H, and...
32 KB (3,700 words) - 00:38, 1 January 2024
hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA). By preferentially modifying hemimethylated DNA, DNMT1 transfers patterns...
159 KB (18,203 words) - 21:52, 9 July 2025
Proliferating cell nuclear antigen (PCNA) is a protein involved in post-replication MMR. It has been shown that PCNA binds to the MutSβ heterodimer via...
17 KB (2,080 words) - 11:40, 15 November 2024
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: A Report of the American...
190 KB (18,276 words) - 01:15, 13 July 2025
et al. (June 2019). "2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA/AGS/APhA/ASPC/NLA/PCNA Guideline on the Management of Blood Cholesterol: Executive Summary: A Report...
111 KB (10,901 words) - 04:13, 30 June 2025
when homozygous, 2735 and D-1368 and all heteroallelic combinations of its Pcna mutations strongly suppress PEV. In mouse, variegating coat colour has been...
12 KB (1,573 words) - 06:36, 10 June 2024
has been shown to interact with: APEX1, BLM CDK2, CCNA2, EP300, HNRNPA1, PCNA, and WRN. FEN1 is over-expressed in the majority of cancers of the breast...
23 KB (2,642 words) - 21:34, 20 February 2024
This diagram (which is interactive) of protein structure uses PCNA as an example. (PDB: 1AXC)...
12 KB (1,345 words) - 23:40, 14 June 2025
proliferating cell nuclear antigen (PCNA) gene. ERCC1 is linked to DNA repair and increased cancer resistance. PCNA is also important in DNA repair. These...
64 KB (7,044 words) - 20:38, 30 June 2025