A protein–ligand complex is a complex of a protein bound with a ligand that is formed following molecular recognition between proteins that interact with...

'to bind'. In protein-ligand binding, the ligand is usually a molecule which produces a signal by binding to a site on a target protein. The binding typically...

selectivity, and stability of these protein-based therapeutics have also been developed. The phrase "drug design" is similar to ligand design (i.e., design of a...

ligands. Over 1100 unique protein-ligand complexes from the Protein Databank were found to form salt bridges with their protein targets, indicating that...

with G proteins. They pass through the cell membrane seven times in the form of six loops (three extracellular loops interacting with ligand molecules...

coordination chemistry, a ligand is an ion or molecule with a functional group that binds to a central metal atom to form a coordination complex. The bonding with...

of the protein, ligand, and protein–ligand complex, respectively. The dissociation constant has molar units (M) and corresponds to the ligand concentration...

Zico, 2022 Complex Networks, publisher of the now-only-online magazine Complex Protein–ligand complex, a complex of a protein bound with a ligand Exosome...

orientation of one molecule to a second when a ligand and a target are bound to each other to form a stable complex. Knowledge of the preferred orientation in...

Protein–ligand docking is a molecular modelling technique. The goal of protein–ligand docking is to predict the position and orientation of a ligand (a...

constant determination of high-affinity protein-ligand complexes by electrospray ionization mass spectrometry and ligand competition". J Mass Spectrom. 43 (5):...

copper proteins, a distorted tetrahedral complex will be formed due to the strong equatorial cysteine ligand and the weak axial methionine ligand. The two...

A molecule that binds to a receptor is called a ligand and can be a protein, peptide (short protein), or another small molecule, such as a neurotransmitter...

binding affinity prediction of diverse protein-ligand complexes. This has also been the case for target-specific complexes, although the advantage is target-dependent...

helical character of a protein and its complex with a diagnostic ligand in solution. The 3D structure of the mTSPO-PK11195 complex comprises five transmembrane...

such as a protein, with a complex structure of components. Protein-ligand binding typically changes the structure of the target protein, thereby changing...

detection method is used to determine the presence and amount of the ligand-receptor complexes formed, and this is usually determined electrochemically or through...

of protein-ligand complex includes displacement of the solvent molecules that occupy the binding site of the ligand, to produce a solvated complex. Because...

Fas ligand (FasL, also known as CD95L or Apo-1L) is a type-II transmembrane protein in the tumor necrosis factor (TNF) superfamily. It binds to the Fas...

Structural proteins that bind DNA are well-understood examples of non-specific DNA-protein interactions. Within chromosomes, DNA is held in complexes with structural...

unfolding between ligand-free protein and protein-ligand complex, or wild type and mutant proteins. DSC can also be used in studying protein/lipid interactions...

the protein-ligand complexes deposited in the Protein Data Bank (PDB). It thus provides a link between energetic and structural information of protein-ligand...

potential of mean force decreases between thrombin and its aptamer (a protein-ligand complex) under the effect of electrical fields. Statistical potential Free...

protein-ligand complex. In order to reset the protein to its original, basic state, it needs ATP. When ATP is consumed or hydrolyzed, the ligand is released...

stable dimeric complex referred to as the beta-gamma complex . Heterotrimeric G proteins located within the cell are activated by G protein-coupled receptors...

dissolve certain metal cations. Thus, proteins, polysaccharides, and polynucleic acids are excellent polydentate ligands for many metal ions. Organic compounds...

mixture of unbound ligands, proteins, ligand-protein complexes is passed through a column of porous beads. Ligand-protein complexes are excluded from entering...

proteins form a characteristic glove shape, encompassing a ligand-binding pocket that accommodates specific small organic chemicals. Urinary proteins...

target gene expression. The TGF beta superfamily of ligands includes: bone morphogenetic proteins (BMPs), growth and differentiation factors (GDFs), anti-Müllerian...

affinity to the target protein. At modern X-ray crystallography synchrotron beamlines, several hundred data sets of protein-ligand complex crystal structures...