Raf-like Ras-binding domain is an evolutionary conserved protein domain. This is the Ras-binding domain found in proteins related to Ras. Human proteins...
1 KB (72 words) - 15:18, 1 October 2024
MAPK/ERK pathway (redirect from Ras Raf Mek)
The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the...
24 KB (3,066 words) - 14:18, 3 June 2025
shows Rap1 in complex with the RBD of c-Raf.) The C1 domain - immediately downstream of the Ras binding domain - is a special zinc finger, rich in cysteines...
69 KB (8,674 words) - 01:09, 28 March 2024
BRAF (gene) (redirect from V-raf murine sarcoma viral oncogene homolog B1)
three conserved domains characteristic of the Raf kinase family: conserved region 1 (CR1), a Ras-GTP-binding self-regulatory domain, conserved region...
50 KB (5,393 words) - 08:57, 15 March 2025
Guanine nucleotide exchange factor (category GTP-binding protein regulators)
of Ras superfamily GTPases have a conserved GTP binding domain, this is not the case for GEFs. Different families of GEFs correspond to different Ras subfamilies...
18 KB (2,253 words) - 09:08, 21 October 2023
GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene. This...
12 KB (1,750 words) - 03:49, 20 October 2022
facilitates the conversion of inactive RAS-GDP to active RAS-GTP, which turns on the cascade of enzymes which the RAS-RAF-MEK-ERK pathway is composed of. All...
52 KB (5,746 words) - 03:46, 31 May 2025
with many receptors via its PTB domain. Once activated, Ras interacts with several proteins, namely Raf. Activated Raf stimulates MAPK-kinase (MAPKK or...
13 KB (1,563 words) - 09:00, 13 March 2024
factor. Raf is activated via the second messenger DAG, SOS, and Ras. DAG recruits among other proteins the RAS guanyl nucleotide-releasing protein (RasGRP)...
44 KB (5,378 words) - 07:54, 5 May 2025
However, Raf activation does not exclusively depend on Ras. Protein kinase C, which is activated by phorbol esters, can fulfill the same function as Ras. MEK...
18 KB (2,465 words) - 23:49, 3 January 2024
contains the Ras-binding domain (RBD) and the cysteine-rich domain (CRD). The RBD facilitates interaction with activated Ras-GTP, anchoring A-Raf to the plasma...
22 KB (2,738 words) - 01:01, 6 May 2025
RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the signaling activity of G-proteins by binding, through...
10 KB (1,213 words) - 08:43, 29 September 2023
et al. (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". The Journal of...
33 KB (4,085 words) - 00:57, 31 May 2025
Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and...
47 KB (4,991 words) - 19:57, 3 June 2025
N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can...
6 KB (682 words) - 13:35, 20 December 2024
the Ras-Nf1 complex assembles, active Ras binds in a groove that is present in the neurofibromin catalytic domain. This binding occurs through Ras switch...
50 KB (5,754 words) - 18:03, 28 May 2025
Trk receptor (redirect from Ras/MapK pathway)
the activation cascades of K-Ras, Raf1, and MEK 1,2, whereas ERK5 is stimulated through the activation cascades of B-Raf, MEK5, and Erk 5. However, whether...
27 KB (3,130 words) - 22:26, 29 May 2025
cell proliferation through pathways like Ras–Raf–MEK–ERK. Structural studies show that Tax1 binds each PDZ domain in Scribble with distinct affinities...
7 KB (705 words) - 23:01, 11 May 2025
major pathways, the Ras/MAPK pathway and the PI3K/Akt pathway. The binding of NGF to TrkA also leads to the activation of PI 3-kinase, ras, and PLC signaling...
27 KB (3,118 words) - 21:39, 29 May 2025
mitogenic signaling pathway in humans is the Ras-Raf-MAPK pathway. Mitogenic signaling normally activates Ras, a GTPase, that then activates the rest of...
13 KB (1,727 words) - 03:34, 17 November 2024
consists of relieving their autoinhibition by a smaller ligand (such as Ras for c-Raf, GADD45 for MEKK4 or Cdc42 for MLK3). This commonly (but not always)...
46 KB (5,510 words) - 21:54, 29 November 2024
of APCCdh1 is the transcription factor Ets2, which is activated by the Ras-Raf-MAPK signalling pathway and induces the expression of cyclin D1. This pathway...
14 KB (1,553 words) - 03:55, 26 August 2024
Phosphorylated tyrosine residues act as binding sites for intracellular signal activators such as Ras. The Ras-Raf-MAPK pathway is a major signalling route...
24 KB (2,736 words) - 16:03, 20 February 2025
exchange of GDP for GTP induces a conformational change of RAS to allow it to bind to Raf-1. Raf-1 is then activated through another multistep mechanism...
6 KB (571 words) - 06:35, 3 March 2025
PLK1 (redirect from Polo-like kinase 1)
et al. (August 2010). "Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation"...
16 KB (1,929 words) - 07:57, 4 January 2024
radioisotope - radioisotopic labelling - Raman spectroscopy - random coil - Ras gene - Ras protein - reading frame - receptor (biochemistry) - receptor antagonist...
29 KB (2,469 words) - 23:55, 12 June 2025
Shc via the phosphorylated tyrosines on its intracellular domain. Through Shc, the RAS/RAF/MEK/ERK pathway is activated along with the p38 and JNK pathways...
10 KB (1,142 words) - 18:22, 2 October 2024