• Raf-like Ras-binding domain is an evolutionary conserved protein domain. This is the Ras-binding domain found in proteins related to Ras. Human proteins...
    1 KB (72 words) - 15:18, 1 October 2024
  • MAPK/ERK pathway (redirect from Ras Raf Mek)
    The MAPK/ERK pathway (also known as the Ras-Raf-MEK-ERK pathway) is a chain of proteins in the cell that communicates a signal from a receptor on the...
    24 KB (3,066 words) - 14:18, 3 June 2025
  • Thumbnail for C-Raf
    shows Rap1 in complex with the RBD of c-Raf.) The C1 domain - immediately downstream of the Ras binding domain - is a special zinc finger, rich in cysteines...
    69 KB (8,674 words) - 01:09, 28 March 2024
  • Thumbnail for BRAF (gene)
    three conserved domains characteristic of the Raf kinase family: conserved region 1 (CR1), a Ras-GTP-binding self-regulatory domain, conserved region...
    50 KB (5,393 words) - 08:57, 15 March 2025
  • Thumbnail for KRAS
    KRAS (redirect from C-K-RAS)
    To transmit signals, it must be turned on by attaching (binding) to a molecule of GTP. The K-Ras protein is turned off (inactivated) when it converts the...
    45 KB (5,077 words) - 21:16, 29 May 2025
  • Thumbnail for Guanine nucleotide exchange factor
    Guanine nucleotide exchange factor (category GTP-binding protein regulators)
    of Ras superfamily GTPases have a conserved GTP binding domain, this is not the case for GEFs. Different families of GEFs correspond to different Ras subfamilies...
    18 KB (2,253 words) - 09:08, 21 October 2023
  • Thumbnail for DIRAS3 (gene)
    GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded by the DIRAS3 gene. This...
    12 KB (1,750 words) - 03:49, 20 October 2022
  • Thumbnail for Philadelphia chromosome
    facilitates the conversion of inactive RAS-GDP to active RAS-GTP, which turns on the cascade of enzymes which the RAS-RAF-MEK-ERK pathway is composed of. All...
    52 KB (5,746 words) - 03:46, 31 May 2025
  • Thumbnail for Platelet-derived growth factor receptor
    with many receptors via its PTB domain. Once activated, Ras interacts with several proteins, namely Raf. Activated Raf stimulates MAPK-kinase (MAPKK or...
    13 KB (1,563 words) - 09:00, 13 March 2024
  • Thumbnail for HRAS
    HRAS (redirect from H-Ras)
    in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H-Ras will activate a Raf kinase like c-Raf, the next...
    10 KB (1,338 words) - 02:39, 13 June 2024
  • Thumbnail for GRB2
    GRB2 (section Domains)
    the activation of Ras and its downstream kinases, ERK1,2. Grb2 is composed of an SH2 domain flanked on each side by an SH3 domain. Grb2 has two closely...
    82 KB (9,365 words) - 09:44, 2 March 2025
  • Thumbnail for T-cell receptor
    factor. Raf is activated via the second messenger DAG, SOS, and Ras. DAG recruits among other proteins the RAS guanyl nucleotide-releasing protein (RasGRP)...
    44 KB (5,378 words) - 07:54, 5 May 2025
  • Thumbnail for ELK1
    However, Raf activation does not exclusively depend on Ras. Protein kinase C, which is activated by phorbol esters, can fulfill the same function as Ras. MEK...
    18 KB (2,465 words) - 23:49, 3 January 2024
  • Thumbnail for ARAF
    contains the Ras-binding domain (RBD) and the cysteine-rich domain (CRD). The RBD facilitates interaction with activated Ras-GTP, anchoring A-Raf to the plasma...
    22 KB (2,738 words) - 01:01, 6 May 2025
  • Thumbnail for RGS14
    RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the signaling activity of G-proteins by binding, through...
    10 KB (1,213 words) - 08:43, 29 September 2023
  • Thumbnail for Glucagon-like peptide-1 receptor
    et al. (June 2016). "Structural Determinants of Binding the Seven-transmembrane Domain of the Glucagon-like Peptide-1 Receptor (GLP-1R)". The Journal of...
    33 KB (4,085 words) - 00:57, 31 May 2025
  • Thumbnail for Molecular glue
    Pan-RAF-MEK Nondegrading Molecular Glue NST-628 Is a Potent and Brain-Penetrant Inhibitor of the RAS-MAPK Pathway with Activity across Diverse RAS- and...
    47 KB (4,991 words) - 19:57, 3 June 2025
  • Thumbnail for RASGRP2
    N-terminal GEF domain, 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. This protein can...
    6 KB (682 words) - 13:35, 20 December 2024
  • Thumbnail for Neurofibromin
    the Ras-Nf1 complex assembles, active Ras binds in a groove that is present in the neurofibromin catalytic domain. This binding occurs through Ras switch...
    50 KB (5,754 words) - 18:03, 28 May 2025
  • the activation cascades of K-Ras, Raf1, and MEK 1,2, whereas ERK5 is stimulated through the activation cascades of B-Raf, MEK5, and Erk 5. However, whether...
    27 KB (3,130 words) - 22:26, 29 May 2025
  • Thumbnail for Tax1
    cell proliferation through pathways like RasRaf–MEK–ERK. Structural studies show that Tax1 binds each PDZ domain in Scribble with distinct affinities...
    7 KB (705 words) - 23:01, 11 May 2025
  • Thumbnail for Nerve growth factor
    major pathways, the Ras/MAPK pathway and the PI3K/Akt pathway. The binding of NGF to TrkA also leads to the activation of PI 3-kinase, ras, and PLC signaling...
    27 KB (3,118 words) - 21:39, 29 May 2025
  • mitogenic signaling pathway in humans is the Ras-Raf-MAPK pathway. Mitogenic signaling normally activates Ras, a GTPase, that then activates the rest of...
    13 KB (1,727 words) - 03:34, 17 November 2024
  • consists of relieving their autoinhibition by a smaller ligand (such as Ras for c-Raf, GADD45 for MEKK4 or Cdc42 for MLK3). This commonly (but not always)...
    46 KB (5,510 words) - 21:54, 29 November 2024
  • Thumbnail for APC/C activator protein CDH1
    of APCCdh1 is the transcription factor Ets2, which is activated by the Ras-Raf-MAPK signalling pathway and induces the expression of cyclin D1. This pathway...
    14 KB (1,553 words) - 03:55, 26 August 2024
  • Phosphorylated tyrosine residues act as binding sites for intracellular signal activators such as Ras. The Ras-Raf-MAPK pathway is a major signalling route...
    24 KB (2,736 words) - 16:03, 20 February 2025
  • exchange of GDP for GTP induces a conformational change of RAS to allow it to bind to Raf-1. Raf-1 is then activated through another multistep mechanism...
    6 KB (571 words) - 06:35, 3 March 2025
  • Thumbnail for PLK1
    PLK1 (redirect from Polo-like kinase 1)
    et al. (August 2010). "Computational analysis of phosphopeptide binding to the polo-box domain of the mitotic kinase PLK1 using molecular dynamics simulation"...
    16 KB (1,929 words) - 07:57, 4 January 2024
  • Thumbnail for Index of biochemistry articles
    radioisotope - radioisotopic labelling - Raman spectroscopy - random coil - Ras gene - Ras protein - reading frame - receptor (biochemistry) - receptor antagonist...
    29 KB (2,469 words) - 23:55, 12 June 2025
  • Thumbnail for Interleukin 31
    Shc via the phosphorylated tyrosines on its intracellular domain. Through Shc, the RAS/RAF/MEK/ERK pathway is activated along with the p38 and JNK pathways...
    10 KB (1,142 words) - 18:22, 2 October 2024