Signal transducing adaptor proteins (STAPs) are proteins that are accessory to main proteins in a signal transduction pathway. Adaptor proteins contain...

Adaptor protein may refer to: Signal transducing adaptor protein Vesicular transport adaptor protein Clathrin adaptor protein, also known as adaptin This...

Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events. Proteins responsible...

receptor binds to an adaptor protein (GRB2), which couples the signal to further downstream signaling processes. For example, one of the signal transduction pathways...

GPCR function. G proteins are important signal transducing molecules in cells. "Malfunction of GPCR [G Protein-Coupled Receptor] signaling pathways are involved...

cellular biology, the Wnt signaling pathways are a group of signal transduction pathways which begin with proteins that pass signals into a cell through cell...

of the MAP/ERK signal transduction pathway are called RASopathies. Janus kinase Phosphatase Signal transducing adaptor protein G protein-coupled receptor...

Different parts of the embryo have different concentrations of hedgehog signaling proteins. The pathway also has roles in the adult. Diseases associated with...

drugs used for cancer therapy. Signal transducing adaptor protein, a helper protein used by major proteins in signalling pathways. Aaronson DS, Horvath...

structures, composed of protein, that receive and transduce signals that may be integrated into biological systems. These signals are typically chemical...

function of this protein. STAM1 contains multiple amino acid sites that are phosphorylated and ubiquitinated. Signal transducing adaptor molecule has been...

transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA...

proteins in the target cell, resulting in a change in cell function. When a hormone binds to the receptor, it results in the activation of a signal transduction...

the cell to have signal transduction mechanisms to transduce first messenger into second messengers, so that the extracellular signal may be propagated...

from proteins to biogenic amines to protons, but all transduce this signal via a mechanism of G-protein coupling. This is made possible by a guanine-nucleotide...

(/ˈsaɪtəkaɪn/) are a broad and loose category of small proteins (~5–25 kDa) important in cell signaling. Cytokines are produced by a broad range of cells,...

targeting of mitochondria functionality, or directly transducing the signal via adaptor proteins to the apoptotic mechanisms. An extrinsic pathway for initiation...

receptor-bound protein 2, also known as Grb2, is an adaptor protein involved in signal transduction/cell communication. In humans, the GRB2 protein is encoded...

transducing forces from the extracellular matrix into the cell. Each chondrocyte has one cilium and it is hypothesized to transmit mechanical signals...

for computer programming Signal transducing adaptor protein, a type of protein involved in cell signalling Blank-firing adaptor, a device which enables...

cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa), also known as LCP2 or SLP-76, is a signal-transducing adaptor protein expressed...

[citation needed] Normally, the Wnt signaling pathway leads to stabilization of β-catenin through inactivation of a protein complex containing the tumor suppressors...

the notch protein composed of a short extracellular region, a single transmembrane-pass, and a small intracellular region. Notch signaling promotes proliferative...

domain of the receptor. An adaptor protein (such as SOS) recognizes the phosphorylated tyrosine on the receptor. This protein functions as a bridge which...

sites Signal transducing adaptor protein, proteins that provide mechanisms by which receptors can amplify and regulate downstream effector proteins Linker...

apoptosis. The pathway takes its name from one of its key signaling components—the protein kinase Hippo (Hpo). Mutations in this gene lead to tissue overgrowth...

cells. They act in cell signaling by receiving (binding to) extracellular molecules. They are specialized integral membrane proteins that allow communication...

brain, spleen, and neonatal kidney. It is a G protein-coupled receptor (GPCR), coupled to the Gi protein, and its activation in the brain mediates hyperpolarization...

prepropeptides also contain a signal peptide, spacer peptides, and cleavage sites. The signal peptide sequence guides the protein to the secretory pathway...

structurally conserved protein domain contained within the Src oncoprotein and in many other intracellular signal-transducing proteins. SH2 domains bind to...