Signaling lymphocytic activation molecule (SLAM) is a family of genes. Homophilic binding between SLAMs is involved in cell-to-cell adhesion during antigen...
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date: complement regulatory molecule CD46, the signaling lymphocyte activation molecule (SLAMF1) and the cell adhesion molecule Nectin-4. For wild type and...
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CD48 (section T-cell activation)
differentiation 48) also known as B-lymphocyte activation marker (BLAST-1) or signaling lymphocytic activation molecule 2 (SLAMF2) is a protein that in humans...
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an enzyme used in research SLAM-associated protein, a signaling lymphocytic activation molecule Select Agent Program of the CDC to regulate select agents...
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CD244 is a type-I transmembrane protein belonging to the signaling lymphocytic activation molecule family of receptors (SLAMF) which are expressed in different...
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Cancer immunotherapy (section Complement Activation)
Elotuzumab is an immunostimulatory antibody that targets the Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7) through two mechanisms. In May...
95 KB (12,767 words) - 20:15, 29 May 2025
Elotuzumab is an immunostimulatory antibody that targets the Signaling Lymphocytic Activation Molecule Family member 7 (SLAMF7) through two mechanisms. In May...
14 KB (1,196 words) - 14:55, 2 July 2024
PI3K/AKT/mTOR pathway (category Signal transduction)
PI3K activation phosphorylates and activates AKT, localizing it in the plasma membrane. AKT can have a number of downstream effects such as activating CREB...
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follicular helper cell IL-4 production is dependent on signaling lymphocytic activation molecule receptor (CD150)". J. Immunol. 185 (1): 190–202. doi:10...
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cells. Through biochemical signaling and by physically acquiring antigens from the immune synapses, the BCR controls the activation of the B cell. B cells...
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"SLAM" refers to signaling lymphocytic activation molecules. It is a SH2 domain–containing molecule (part of a family of such molecules) that plays a role...
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antigen-presenting cells and is required for their activation. The binding of CD154 (CD40L) on TH cells to CD40 activates antigen presenting cells and induces a variety...
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Hashimoto's thyroiditis (redirect from Chronic lymphocytic thyroiditis)
Hashimoto's thyroiditis, also known as chronic lymphocytic thyroiditis, Hashimoto's disease and autoimmune thyroiditis, is an autoimmune disease in which...
105 KB (10,910 words) - 06:29, 17 June 2025
Lymphocyte (redirect from Lymphocytic)
recognizing changes of a surface molecule called major histocompatibility complex (MHC) class I. NK cells are activated in response to a family of cytokines...
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(Oct 1998). "CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling". Journal of Immunology. 161 (8): 4058–65. doi:10...
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The following is a list of human clusters of differentiation (or CD) molecules. * = group; ** = not listed on hcdm Bennett JS. Structure and function...
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Gasotransmitter (category Gaseous signaling molecules)
class of neurotransmitters. The molecules are distinguished from other bioactive endogenous gaseous signaling molecules based on a need to meet distinct...
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Antibody (section Activation of complement)
cell ready to respond to antigen. B cell activation follows engagement of the cell-bound antibody molecule with an antigen, causing the cell to divide...
126 KB (13,987 words) - 21:10, 19 June 2025
missile project of the 1950, nicknamed the flying crowbar Signaling lymphocytic activation molecule (or SLAM), a family of genes Body slam, any move in which...
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Biological functions of nitric oxide (category Gaseous signaling molecules)
monoxide) is a molecule and chemical compound with chemical formula of NO. In mammals including humans, nitric oxide is a signaling molecule involved in...
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cytokines and the activation of monocytes. It is used to slow down the progression of multiple sclerosis. IFN-γ is able to trigger lymphocytic apoptosis. Prolonged...
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Acute lymphoblastic leukemia (redirect from Acute lymphocytic leukaemia)
doi:10.1016/S0140-6736(16)31678-6. PMC 5055577. PMID 27733282. "Acute Lymphocytic Leukemia – Cancer Stat Facts". SEER. Retrieved 20 December 2017. Tubergen...
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Ibrutinib (category Small-molecule drugs)
the treatment of mantle cell lymphoma (MCL), chronic lymphocytic leukemia (CLL)/small lymphocytic lymphoma (SLL), Waldenström's macroglobulinemia (WM)...
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Oncogene (section Activation)
without signals from outside the cell. Ras is a small GTPase that hydrolyses GTP into GDP and phosphate. Ras is activated by growth factor signaling (i.e...
28 KB (3,162 words) - 09:06, 29 May 2025
RANKL (redirect from Receptor activator of nuclear factor kappa-B ligand)
adequate bone metabolism. This surface-bound molecule (also known as CD254), found on osteoblasts, serves to activate osteoclasts, which are critically involved...
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of a number of cancers, including melanoma, breast, prostate, chronic lymphocytic leukemia, and lung cancer, and a possible cause of schizophrenia and...
41 KB (4,585 words) - 06:18, 9 June 2025
and CD28 costimulatory molecule. This protein interaction is also essential for T lymphocytes to receive the full activation signal, which in turn leads...
27 KB (3,221 words) - 16:19, 13 October 2024
"Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229". J. Immunol...
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G protein signaling. PIP3 binds and inhibits the RGS4 GAP. Such inhibition of GAP may perhaps "prime" the signaling pathway for activation. This creates...
16 KB (2,237 words) - 20:38, 22 July 2024