NAD-dependent deacetylase sirtuin-3, mitochondrial also known as SIRT3 is a protein that in humans is encoded by the SIRT3 gene [sirtuin (silent mating type...

Sirtuin 1, also known as NAD-dependent deacetylase sirtuin-1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin (silent...

Sirtuins are a family of signaling proteins involved in metabolic regulation. They are ancient in animal evolution and appear to possess a highly conserved...

but are completely rescued by SARM1 deletion. Activation of NMNAT2 by Sirtuin 3 (SIRT3) may be a means of inhibiting axon degeneration and dysfunction...

resveratrol itself which acts as a sirtuin activator, 4-bromoresveratrol acts as a selective inhibitor of the sirtuin enzymes SIRT1 and SIRT3. In animal...

Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory...

NAD-dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD+ (nicotinamide adenine dinucleotide)-dependent...

studies). Suppression of insulin resistance by sirtuins accounts for at least some of this effect. Impaired sirtuin 3 leads to mitochondrial dysfunction. Rapamycin...

NAD-dependent deacetylase sirtuin 7 is an enzyme that in humans is encoded by the SIRT7 gene. SIRT7 is member of the mammalian sirtuin family of proteins, which...

Sirtuin-activating compounds (STAC) are chemical compounds having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from...

Sirtuin 4, also known as SIRT4, is a mitochondrial protein which in humans is encoded by the SIRT4 gene. SIRT4 is member of the mammalian sirtuin family...

Guarente L (March 2014). "SIRT1 and other sirtuins in metabolism". Trends in Endocrinology and Metabolism. 25 (3): 138–145. doi:10.1016/j.tem.2013.12.001...

found to be a potent sirtuin 6 (SIRT6) activator. Antirrhinin (cyanidin-3-rutinoside or 3-C-R), found in black raspberry Cyanidin-3-xylosylrutinoside, found...

(2018). "Regulatory Effects of NAD + Metabolic Pathways on Sirtuin Activity". Sirtuins in Health and Disease. Progress in Molecular Biology and Translational...

consequences. It arises through epigenetic modification (e.g., through HDAC, sirtuin, and G9a) and transcriptional regulation (primarily through ΔFosB's AP-1...

Sirtuin (silent mating type information regulation 2 homolog) 5 (S. cerevisiae), also known as SIRT5 is a protein which in humans in encoded by the SIRT5...

glucose tolerance. miR-34a represses the translation of sirtuin 1 (SIRT1) in liver by binding to the 3′-UTR region of SIRT1 messenger RNA, contributing to...

to the sirtuin family, a broadly conserved family of NAD+-dependent protein deacetylases. CobB is a bacterial protein that belongs to the sirtuin family...

classical arginase fold and are structurally and mechanistically distinct from sirtuins (class III), which fold into a Rossmann architecture and are NAD+ dependent...

PMID 31903720. Li YH, Choi DH, Lee EH, Seo SR, Lee S, Cho EH (May 2016). "Sirtuin 3 (SIRT3) Regulates α-Smooth Muscle Actin (α-SMA) Production through the...

their name to a class of mammalian histone deacetylases (Sirtuins, homologs of Sir2). Sirtuins have been implicated in myriad human traits including Alzheimer's...

endproducts inhibitory effects. It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to...

several co-repressors, including HDAC1 (histone deacetylase 1) and SIRT 1 (sirtuin 1). ... The net result is c-fos gene repression. Figure 4: Epigenetic basis...

deacetylase (HDAC) families of enzymes, but not class III HDACs (i.e., sirtuins). However, there are recent reports of the interactions of this molecule...

unsettled. Because NADH is a cofactor for processes inside mitochondria, for sirtuins and PARP, NMN has been studied in animal models as a potential neuroprotective...

phosphate synthetase I (CPS I), interacts with a class of molecules called sirtuins, NAD dependent protein deacetylases, and ATP to form carbamoyl phosphate...

mononucleotide Niacin Nicotinamide Vitamin B3 Nicotinamide adenine dinucleotide Sirtuin Poly (ADP-ribose) polymerase Campbell, MT; Jones, DS; Andrews, GP; Li,...

vital for DNA repair and maintaining cellular health through proteins like sirtuins. Chronic ethanol consumption is increasingly understood to contribute to...

SP-624 is a sirtuin-6 (SIRT6) activator which is under development for the treatment of major depressive disorder and schizophrenia. It is taken by mouth...

studied by Sirtris Pharmaceuticals as a small-molecule activator of the sirtuin subtype SIRT1. The compound progressed to Phase II human trials for Type...