also known as TCF7L2 or TCF4, is a protein acting as a transcription factor that, in humans, is encoded by the TCF7L2 gene. The TCF7L2 gene is located...

mutations in other genes with function similar to APC such as AXIN1, AXIN2, TCF7L2, or NKD1. Beyond the defects in the Wnt signaling pathway, other mutations...

Carlsson, Sofia (2019). "Interaction Between Overweight and Genotypes of HLA, TCF7L2, and FTO in Relation to the Risk of Latent Autoimmune Diabetes in Adults...

only account for 10% of the total heritable component of the disease. The TCF7L2 allele, for example, increases the risk of developing diabetes by 1.5 times...

Corporation, a holding company TCF Bank TCF-1 or HNF1A, a gene TCF4 or TCF7L2, a protein transcription factor TCF/LEF family of transcription factors...

family) LEF1 (Lymphoid enhancer-binding factor 1) TCF7 (TCF-1) TCF7L1 (TCF-3) TCF7L2 (TCF-4) HMG proteins are thought to play a significant role in various human...

P15884 16432 TCF7 HGNC:11639 P36402 16433 TCF7L1 HGNC:11640 Q9HCS4 16434 TCF7L2 HGNC:11641 Q9NQB0 16435 TCF12 HGNC:11623 Q99081 16436 TCF15 HGNC:11627 Q12870...

resistance. Mutations in Wnt signaling-associated transcription factors, such as TCF7L2, are linked to increased susceptibility. AXIN1 GSK-3 Management of hair...

and CCNL1, and four that show some evidence (CDKAL1, HHEX–IDE, GCK, and TCF7L2). The heritability of birth weight ranges from 25 to 40%. There is a complex...

research racial disparities in health. He worked with Charles Rotimi on the TCF7L2 protein and susceptibility for Type 2 diabetes in Western African populations...

protein-DNA complex lamellipodium beta-catenin-TCF complex beta-catenin-TCF7L2 complex centrosome Z discdkac bicellular tight junction transcription regulator...

"Identification of FERM domain-containing protein 5 as a novel target of β-catenin/TCF7L2 complex". Cancer Science. 108 (4): 612–619. doi:10.1111/cas.13174. ISSN 1349-7006...

, several SNPs in IGF2 and HLA-B genes; the SNP, rs7903146, within the TCF7L2 gene; the intergenic SNP, rs7560163, located between the RBM43 gene and...

TCF7 (also called TCF1) LEF1 (also called TCF1α) TCF7L1 (also called TCF3) TCF7L2 (also called TCF4) Further diversity comes from expression from the same...

group's genomes), and genes associated with type 2 diabetes, including TCF7L2, PPARG, FTO, KCNJ11, NOTCH2, WFS1, IGF2BP2, SLC30A8, JAZF1, HHEX, DGKB,...

associated with an increased risk of gestational diabetes, most notably TCF7L2. The MTNR1B gene is a common gene that is associated with how the body handles...

Yaksi E, Poggi L, Zigman M, Lin S, Wilson SW, Carl M (October 2014). "Tcf7l2 is required for left-right asymmetric differentiation of habenular neurons"...

microsatellites have successfully led to discoveries of type 2 diabetes (TCF7L2) and prostate cancer genes (the 8q21 region). Microsatellites were popularized...

ENSG00000152284 HMG/Sox Known motif – High-throughput in vitro [921] AAAGATCAAAGG TCF7L2 ENSG00000148737 HMG/Sox Known motif – from protein with 100% identical DBD...

transcription regulator complex nucleus beta-catenin-TCF complex beta-catenin-TCF7L2 complex Biological process cell differentiation regulation of transcription...

publishes its discoveries in peer-reviewed journals, and many, such as the TCF7L2 variants in type 2 diabetes, are used as standard risk markers in polygenic...

is indicated to be involved in type II diabetes. Mutations in CDKAL1 and TCF7L2 have been associated with low production of insulin. Some studies indicate...

or genes that lead to that disease. For example, a genetic variation of TCF7L2 in Japanese population influences one's susceptibility to diabetes; however...

another member of the ZIC family, has recently been found to interact with TCF7L2, enabling it to act as a Wnt/β-catenin signalling inhibitor. Further experiments...

2007, studying the diabetes risk variant TCF7L2 in West African populations. He demonstrated that both TCF7L2 and its genetic variant HapA increase the...

"HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression". International...

binding cadherin binding Cellular component cytoplasm cytosol gamma-catenin-TCF7L2 complex lateral plasma membrane membrane intercalated disc cell-cell junction...

deCODE discovered the link between type 2 diabetes (T2D) and variants in the TCF7L2 gene, the most important common known genetic risk factor known, and variants...

their effect sizes do not seem to be substantial: OR 1.37 for SNPs in the TCF7L2 gene purported to give highest genetic risk. In 2009, a study was conducted...

member on chromosome 13. ZIC2 has recently been found to interact with TCF7L2, enabling it to act as a Wnt/β-catenin signalling inhibitor. Such a role...