The thromboxane receptor (TP) also known as the prostanoid TP receptor is a protein that in humans is encoded by the TBXA2R gene, The thromboxane receptor...

asthma. Thromboxane acts by binding to any of the thromboxane receptors, G-protein-coupled receptors coupled to the G protein Gq. Thromboxane is a vasoconstrictor...

increases platelet aggregation. This is achieved by activating the thromboxane receptor, which results in platelet-shape change, inside-out activation of...

a thromboxane synthase inhibitor and as a thromboxane receptor antagonist. The human thromboxane A (TXA) synthase is a 60 kDa cytochrome P450 protein with...

platelet-aggregating action of thromboxanes. Terbogrel is an orally available thromboxane A2 receptor antagonist and a thromboxane A synthase inhibitor. The...

a thromboxane synthase inhibitor and a thromboxane receptor inhibitor, the latter by modifying cellular responses to activation of the thromboxane receptor...

Ifetroban is a potent and selective thromboxane receptor antagonist. It has been studied in animal models for the treatment of cancer metastasis, myocardial...

Bronica) is a thromboxane A2 (TXA2) receptor (TP receptor) antagonist used primarily in the treatment of asthma. It was the first TP receptor antagonist...

(PGI2), thromboxane A2 (TXA2), and PGH2. They are named based on the prostanoid to which they preferentially bind and respond, e.g. the receptor responsive...

dilation of blood vessels stimulating platelet aggregation binds to thromboxane receptor on platelets' cell membranes to trigger platelet migration and adhesion...

Ramatroban (INN; also known as BAY u3405) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist. Ramatroban is indicated for the treatment...

signaling pathways and responses. TXA2 (thromboxane): TP-(TXA2) (TBXA2R) – TBXA2R; TP is the receptor for thromboxane A2; relative potencies in binding to...

from thromboxane A2 (TXA2) binding (leading to platelet activation and subsequent coagulation). PGI2 also binds to endothelial prostacyclin receptors, and...

various prostaglandins (which mediate pain, inflammation, and fever) and thromboxane A2 (which stimulates platelet aggregation and promotes blood clot formation)...

Walsh; et al. (2005-08-01) [Published on Journal website 2005-07-26]. "Thromboxane A2-induced contraction of rat caudal arterial smooth muscle involves...

prostaglandin-endoperoxide synthase, PTGS) enzyme required for prostaglandin and thromboxane synthesis.[medical citation needed] Aspirin acts as an acetylating agent...

function of FP receptors in these responses. Gene knockout studies in mice clearly show that FP mediates the late phase (thromboxane receptor mediates the...

well as regulating the contraction of smooth muscle tissue. Conversely, thromboxanes (produced by platelet cells) are vasoconstrictors and facilitate platelet...

of GABA receptors: GABAA and GABAB. GABAA receptors are ligand-gated ion channels (also known as ionotropic receptors); whereas GABAB receptors are G protein-coupled...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

99.1) that is responsible for biosynthesis of prostanoids, including thromboxane and prostaglandins such as prostacyclin, from arachidonic acid. A member...

agonist of cannabinoid receptors CB1 and CB2, an inhibitor of endocannabinoid transporter, and a potent activator of TRPV1 receptor. This and other research...

Antagonists: RO1138452 TP (TXA2)Tooltip Thromboxane receptor Agonists: Carbocyclic thromboxane A2 I-BOP Thromboxane A2 U-46619 Vapiprost Antagonists: 12-HETE...

inhibited by nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin. Thromboxane A2, the major product of COX-1 in platelets, induces platelet aggregation...

endocannabinoid 2-arachidonoylglycerol an activator of a subfamily of transient receptor potential canonical (TRPC) cation channels, TRPC3/6/7. Synthesis of diacylglycerol...

Protease-activated receptor-1 antagonists (which inhibit the protease-activated receptor 1 a.k.a. PAR-1) Vorapaxar (Zontivity) Thromboxane inhibitors Thromboxane receptor...

Cell surface receptors (membrane receptors, transmembrane receptors) are receptors that are embedded in the plasma membrane of cells. They act in cell...

protein-coupled receptors (GPCRs), also known as seven-(pass)-transmembrane domain receptors, 7TM receptors, heptahelical receptors, serpentine receptors, and G...

prostaglandins (mediators of inflammatory and anaphylactic reactions), the thromboxanes (mediators of vasoconstriction), and the prostacyclins (active in the...