Thymidylate synthase (TS) (EC 2.1.1.45) is an enzyme that catalyzes the conversion of deoxyuridine monophosphate (dUMP) to deoxythymidine monophosphate...
16 KB (1,907 words) - 04:17, 2 June 2025
Thymidylate synthase inhibitors are chemical agents which inhibit the enzyme thymidylate synthase and have potential as an anticancer chemotherapy. This...
4 KB (380 words) - 00:05, 20 March 2025
Raltitrexed (category Thymidylate synthase inhibitors)
antimetabolite drug used in cancer chemotherapy. It is an inhibitor of thymidylate synthase, and is manufactured by AstraZeneca. Used in treatment of colorectal...
5 KB (311 words) - 10:47, 25 May 2025
Capecitabine is metabolised to 5-FU which in turn is a thymidylate synthase inhibitor, hence inhibiting the synthesis of thymidine monophosphate...
17 KB (1,409 words) - 16:47, 16 July 2025
Fluorouracil (category Thymidylate synthase inhibitors)
entirely clear, but it is believed to involve blocking the action of thymidylate synthase and thus stopping the production of DNA. Fluorouracil was patented...
34 KB (3,131 words) - 17:20, 16 July 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
12 KB (896 words) - 03:39, 19 June 2025
methyl group onto the uracil base of dUMP to generate dTMP. The thymidylate synthase reaction, dUMP + 5,10-methylenetetrahydrofolate ⇔ dTMP + dihydrofolate...
62 KB (6,774 words) - 02:19, 28 June 2025
In enzymology, a thymidylate synthase (FAD) (EC 2.1.1.148) is an enzyme that catalyzes the chemical reaction 5,10-methylenetetrahydrofolate + dUMP + FADH2...
3 KB (244 words) - 21:45, 25 April 2025
with the alpha-subunit of tryptophan (TSA) synthase to yield indole. The beta-subunit of tryptophan synthase (TSB) catalyzes condensation of indole with...
25 KB (2,517 words) - 19:48, 6 March 2025
Fluorodeoxyuridylate (category Thymidylate synthase inhibitors)
5-fluorouracil and 5-fluorodeoxyuridine. FdUMP acts as a suicide inhibitor of thymidylate synthase (TS). By inhibiting the deoxynucleotide biosynthesis, FdUMP stops...
11 KB (1,304 words) - 20:08, 18 October 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
20 KB (1,843 words) - 15:38, 20 April 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
21 KB (1,824 words) - 12:17, 23 June 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
34 KB (3,159 words) - 14:47, 12 July 2025
Kitamura H, Nomura N, Danenberg PV, Kubota Y (2005). "Expression of thymidylate synthase, dihydropyrimidine dehydrogenase, thymidine phosphorylase, and orotate...
28 KB (3,560 words) - 20:45, 22 July 2024
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
27 KB (2,446 words) - 16:23, 8 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
24 KB (2,150 words) - 20:42, 28 June 2025
liposomal thymidylate synthase inhibitor. OSI-7904 is a benzoquinazoline folate analog with antineoplastic activity. As a thymidylate synthase inhibitor...
4 KB (222 words) - 23:24, 5 April 2023
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
64 KB (6,345 words) - 01:52, 15 July 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
17 KB (1,680 words) - 23:09, 21 June 2025
It bypasses several metabolic steps in the body and better binds thymidylate synthase with FdUMP, a metabolite of the drug fluorouracil. In March 2012...
15 KB (1,217 words) - 17:46, 16 July 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
12 KB (1,041 words) - 04:31, 2 June 2025
dUMP (2′-deoxyuridine-5′-phosphate). The conversion is catalyzed by thymidylate synthase. Methyl-THF converts vitamin B12 to methyl-B12 (methylcobalamin)...
107 KB (11,361 words) - 21:20, 28 June 2025
(where uracil is used instead), inhibition of thymidine synthesis via thymidylate synthase selectively inhibits DNA synthesis over RNA synthesis. Due to their...
11 KB (1,239 words) - 22:33, 24 May 2025
Pemetrexed (category Thymidylate synthase inhibitors)
inhibiting three enzymes used in purine and pyrimidine synthesis—thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide...
16 KB (1,212 words) - 21:50, 29 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
21 KB (1,942 words) - 11:17, 9 June 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
32 KB (2,944 words) - 22:19, 29 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
19 KB (1,732 words) - 11:10, 11 July 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
27 KB (2,339 words) - 21:12, 29 May 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
18 KB (1,475 words) - 02:51, 19 June 2025
reductase inhibitor (Aminopterin Methotrexate# Pemetrexed Pralatrexate) Thymidylate synthase inhibitor (Pemetrexed Raltitrexed) Purine Adenosine deaminase inhibitor...
12 KB (1,281 words) - 15:47, 26 May 2025