Ubiquitin-activating enzymes, also known as E1 enzymes, catalyze the first step in the ubiquitination reaction, which (among other things) can target a...
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peptide fragments for recycling by the cell. A ubiquitin-activating enzyme, or E1, first activates the ubiquitin by covalently attaching the molecule to its...
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steps: activation, conjugation, and ligation, performed by ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and ubiquitin ligases...
101 KB (11,338 words) - 19:50, 22 April 2025
Proteasome (redirect from Ubiquitin proteosome system)
the Ubiquitin-activating enzyme (E1), Ubiquitin-conjugating enzyme (E2), and ubiquitin ligases (E3). Once a protein is tagged with a single ubiquitin molecule...
140 KB (16,845 words) - 21:59, 29 May 2025
Deubiquitinating enzymes (DUBs), also known as deubiquitinating peptidases, deubiquitinating isopeptidases, deubiquitinases, ubiquitin proteases, ubiquitin hydrolases...
37 KB (4,317 words) - 07:27, 24 January 2025
Ubiquitin-like modifier activating enzyme 1 (UBA1) is an enzyme which in humans is encoded by the UBA1 gene. UBA1 participates in ubiquitination and the...
20 KB (2,374 words) - 07:00, 18 December 2023
A ubiquitin ligase (also called an E3 ubiquitin ligase) is a protein that recruits an E2 ubiquitin-conjugating enzyme that has been loaded with ubiquitin...
40 KB (4,436 words) - 07:10, 2 June 2025
enzymes are involved in pupylation. The enzymes involved in pupylation are descended from glutamine synthetase.[citation needed] Similar to ubiquitin...
16 KB (1,725 words) - 14:03, 5 September 2024
SUMO protein (redirect from Small ubiquitin-like modifier)
In molecular biology, SUMO (Small Ubiquitin-like Modifier) proteins are a family of small proteins that are covalently attached to and detached from other...
40 KB (4,909 words) - 18:03, 25 May 2025
for ubiquitin itself. The process of ubiquitination is a tightly regulated three-step sequence: activation, performed by ubiquitin-activating enzymes (E1);...
28 KB (3,106 words) - 03:25, 28 May 2025
Ubiquitin-like modifier-activating enzyme 6 is a protein that in humans is encoded by the UBA6 gene. GRCh38: Ensembl release 89: ENSG00000033178 – Ensembl...
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CBL (gene) (redirect from Cbl ubiquitin ligase)
E3 ubiquitin-protein ligase CBL is an enzyme that is humans is encoded by the CBL (Casitas B-lineage Lymphoma) gene. CBL gene is the founding member the...
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Yamaguchi, a city in Japan Ube Industries, chemical company Ubiquitin-activating enzyme Unbiennium, an undiscovered superactinide chemical element Uniform...
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Cullin (section Cullin-RING ubiquitin ligases)
support for ubiquitin ligases (E3). All eukaryotes appear to have cullins. They combine with RING proteins to form Cullin-RING ubiquitin ligases (CRLs)...
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involves the sequential action of three enzymes. First, an E1 ubiquitin-activating enzyme binds to inactive Ub in eukaryotic cells via a thioester bond...
47 KB (5,731 words) - 05:58, 21 May 2025
Ubiquitin-like modifier-activating enzyme 7 is a protein that in humans is encoded by the UBA7 gene. The modification of proteins with ubiquitin is an...
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at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s....
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activation process by E1, an ATP-dependent ubiquitin activating enzyme. The carboxyl terminal (C-terminus) of ubiquitin is linked to the cysteine residue of...
17 KB (2,244 words) - 11:45, 4 January 2024
UBA2 (redirect from SUMO-activating enzyme subunit 2)
Ubiquitin-like 1-activating enzyme E1B (UBLE1B) also known as SUMO-activating enzyme subunit 2 (SAE2) is an enzyme that in humans is encoded by the UBA2...
18 KB (2,212 words) - 18:35, 28 May 2025
Ubiquitin-like modifier-activating enzyme 5 is a protein that in humans is encoded by the UBA5 gene. This gene encodes a member of the E1-like activating...
7 KB (656 words) - 22:25, 3 March 2023
Endoplasmic-reticulum-associated protein degradation (section Ubiquitin-dependent degradation by the proteasome)
reactions. The first of these reactions takes place when the ubiquitin-activating enzyme E1 hydrolyses ATP and forms a high-energy thioester linkage between...
13 KB (1,709 words) - 20:13, 25 May 2025
NEDD8-activating enzyme E1 catalytic subunit is a protein that in humans is encoded by the UBA3 gene. The modification of proteins with ubiquitin is an...
10 KB (1,151 words) - 22:25, 3 March 2023
ubiquitin-like protein NEDD8 is conjugated to its target proteins. This process is analogous to ubiquitination, although it relies on its own enzymes...
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2.1.44: 3-(methylthio)propionyl—CoA ligase * EC 6.2.1.45: E1 ubiquitin-activating enzyme * EC 6.2.1.46: L-allo-isoleucine—holo-[CmaA peptidyl-carrier...
25 KB (2,819 words) - 22:08, 27 March 2025
three enzymes that function in the ubiquitination pathway: Ubiquitin-activating enzyme (E1), Ubiquitin-conjugating enzyme (E2), and Ubiquitin-protein...
14 KB (1,476 words) - 11:33, 30 April 2024
signal Ubiquitin (ubiquitylation) E1 Ubiquitin-activating enzyme UBA1 UBA2 UBA3 UBA5 UBA6 UBA7 ATG7 NAE1 SAE1 E2 Ubiquitin-conjugating enzyme A B C D1...
11 KB (1,152 words) - 17:58, 25 May 2025
involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This...
7 KB (870 words) - 23:19, 4 April 2025
at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s....
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SUMO-conjugating enzyme UBC9 is an enzyme that in humans is encoded by the UBE2I gene. It is also sometimes referred to as "ubiquitin conjugating enzyme E2I" or...
24 KB (2,840 words) - 09:41, 17 February 2023
at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s....
7 KB (788 words) - 01:42, 17 April 2022