Proteins can specifically bind to ubiquitin via ubiquitin-binding domains (UBDs). The distances between individual ubiquitin units in chains differ between...

Ubiquitin-binding domains (UBDs) are protein domains that recognise and bind non-covalently to ubiquitin through protein-protein interactions. As of 2019...

for protein degradation. UBA domains are among the most common ubiquitin-binding domains. Proteins containing UBA domains are involved in a variety of...

the causative mutation was in the UCHL1 gene (specifically, the ubiquitin binding domain, E7A) display blindness, cerebellar ataxia, nystagmus, dorsal column...

as a ubiquitin receptor using a Yeast-2-hybrid screen. Ubiquitin binding to Rpn13 is through the pleckstrin-like receptor for the Ub (PRU) domain. and...

and a substrate binding domain, which gives the E3 its substrate specificity. Ubiquitin signaling relies on the diversity of ubiquitin tags for the specificity...

connections to ubiquitin and the ubiquitination pathway. The ubiquitin associated domain is thought to be a non-covalent ubiquitin-binding domain consisting...

results: Ubiquitin Binding Behavior: Binding to the different ubiquitin-binding domains (UBDs) within ESCRT-0 is non-cooperative, meaning each domain interats...

proteins with RING finger domains are the largest type of ubiquitin ligases in the human genome. Zinc finger (Znf) domains are relatively small protein...

Rev1 has three regions of interest in the BRCT domain, ubiquitin-binding domain, and C-terminal domain and has dCMP transferase ability, which adds deoxycytidine...

ubiquitin proteases, ubiquitin hydrolases, or ubiquitin isopeptidases, are a large group of proteases that cleave ubiquitin from proteins. Ubiquitin is...

domain was found to have a ubiquitin-like structure. It bears 27,6% of homology with Ubiquitin-1 and a β1-β2-α1-β3-β4-β5-β6 + 2*SO42- form. Ubiquitin-like...

Cbl's adaptor functions C-terminal ubiquitin-associated domain (UBA domain): the site of ubiquitin binding This domain structure and the tyrosine and serine-rich...

their L/PPXY motifs, bind the WW domain of the Rsp5 ubiquitin ligase. By binding to both the membrane protein and ubiquitin ligase, α-arrestins serve as a...

are over 53,000 SUMO binding sites, making it a substantial component of fundamental biology. SUMO proteins are similar to ubiquitin and are considered...

E3 ubiquitin ligases that target different substrates. RBX1 – Rbx1 contains a small, zinc-binding Really Interesting New Gene (RING) finger domain, to...

structurally conserved binding region. The E3 molecule is responsible for binding the target protein substrate and transferring the ubiquitin from the E2 cysteine...

encoded by the UBC gene in humans. Polyubiquitin-C is one of the sources of ubiquitin, along with UBB, UBA52, and RPS27A. UBC gene is one of the two stress-regulated...

The Hsp90 protein contains three functional domains, the ATP-binding, protein-binding, and dimerizing domain, each of which playing a crucial role in the...

C, Dikic I (April 2009). "Functional roles of ubiquitin-like domain (ULD) and ubiquitin-binding domain (UBD) containing proteins". Chemical Reviews. 109...

chromatin-associated ubiquitin ligase, binding to histones is direct and shows a remarkable preference for histone H3 and its N-terminal tail. The SRA-YDG domain contained...

protein-protein interactions in ubiquitin and ADP ribose conjugation systems (Poly ADP ribose polymerase). This domain is found as a tandem repeat at the...

of HECT-containing ubiquitin-ligases (E3s) from plants, and several proteins containing ubiquitin-associated UBA and/or UBX domains. In most of these proteins...

called the DNA-binding domain (DBD or often also abbreviated as BD) and activating domain (AD). The BD is the domain responsible for binding to the UAS and...

regulated by the attachment of the ubiquitin-like protein NEDD8 to a conserved Lys residue in the cullin-homology domain, the process called neddylation...

Parkin is a 465-amino acid residue E3 ubiquitin ligase, a protein that in humans and mice is encoded by the PARK2 gene. Parkin plays a critical role in...

phosphotyrosine-independent ligand of the SH2 domain of p56lck, belongs to a new class of ubiquitin-binding proteins". J. Biol. Chem. 271 (34): 20235–7...

glycoproteins for degradation by facilitating binding of ERAD lectins OS9 and XTP3-B. Because the ubiquitin–proteasome system (UPS) is located in the cytosol...

AR, Frisch SM (Apr 2003). "Fas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance...

module is ubiquitin-like. The C-terminal module is a PH-like domain. The FERM domain has also been called the amino-terminal domain, the 30kDa domain, 4.1N30...