• Arachidonate 5-lipoxygenase, also known as ALOX5, 5-lipoxygenase, 5-LOX, or 5-LO, is a non-heme iron-containing enzyme (EC 1.13.11.34) that in humans...
    61 KB (7,557 words) - 15:41, 17 July 2025
  • Arachidonate 5-lipoxygenase inhibitors are compounds that slow or stop the action of the arachidonate 5-lipoxygenase (5-lipoxygenase or 5-LOX) enzyme...
    11 KB (1,301 words) - 20:00, 29 May 2025
  • medication which functions as a leukotriene-related enzyme inhibitor (arachidonate 5-lipoxygenase) or leukotriene receptor antagonist (cysteinyl leukotriene receptors)...
    10 KB (1,024 words) - 19:59, 29 May 2025
  • Thumbnail for 5-lipoxygenase-activating protein
    Arachidonate 5-lipoxygenase-activating protein also known as 5-lipoxygenase activating protein, or FLAP, is a protein that in humans is encoded by the...
    14 KB (1,738 words) - 14:57, 17 July 2025
  • Thumbnail for Lipoxygenase
    are as follows: Arachidonate 5-lipoxygenase (ALOX5) (EC 1.13.11.34; InterPro: IPR001885), also termed 5-lipoxygenase, 5-LOX, and 5-LO. Major products:...
    32 KB (3,890 words) - 12:37, 2 July 2025
  • fatty acid found primarily in seed oils. When acting on GLA, arachidonate 5-lipoxygenase produces no leukotrienes and the conversion by the enzyme of...
    10 KB (976 words) - 18:51, 15 September 2024
  • Thumbnail for Leukotriene
    Leukotriene (redirect from Leukotriene-5)
    essential fatty acid eicosapentaenoic acid (EPA) by the enzyme arachidonate 5-lipoxygenase. Leukotrienes use lipid signaling to convey information to either...
    17 KB (1,895 words) - 16:42, 21 April 2025
  • Thumbnail for ALOX15
    ALOX15 (also termed arachidonate 15-lipoxygenase, 15-lipoxygenase-1, 15-LO-1, 15-LOX-1) is, like other lipoxygenases, a seminal enzyme in the metabolism...
    44 KB (5,708 words) - 00:14, 16 June 2025
  • Thumbnail for ALOX12
    13.11.31), also known as arachidonate 12-lipoxygenase, 12-lipoxygenase, 12S-Lipoxygenase, 12-LOX, and 12S-LOX is a lipoxygenase-type enzyme that in humans...
    32 KB (3,928 words) - 16:20, 16 July 2025
  • agents which function as leukotriene-related enzyme inhibitors (arachidonate 5-lipoxygenase) or leukotriene receptor antagonists (cysteinyl leukotriene receptors)...
    25 KB (2,502 words) - 07:36, 21 July 2025
  • Thumbnail for 5-Hydroxyeicosatetraenoic acid
    arachidonate-5-lipoxygenase, 5-lipoxygenase, 5-LO, and 5-LOX). ALOX5 metabolizes arachidonic acid to its hydroperoxide derivative, arachidonic acid 5-hydroperoxide...
    48 KB (6,107 words) - 08:55, 31 December 2024
  • Thumbnail for Eicosanoid
    metabolized to the 3 double bond-containing analog of 5-HETE viz., 5-HETrE (see Arachidonate 5-lipoxygenase § Mead acid). Hydroxyeicosatetraenoic acids, leukotrienes...
    86 KB (9,651 words) - 01:15, 12 July 2025
  • metabolites of arachidonate 5-lipoxygenase (5-LOX): 5-hydroxyeicosatetraenoic acid (5-(S)-HETE), and its 5-keto analog 5-oxo-eicosatetraenoic acid (5-oxo-ETE)...
    12 KB (1,777 words) - 01:49, 24 September 2024
  • Leukotriene A4 synthase may refer to: Arachidonate 5-lipoxygenase, an enzyme Arachidonate 12-lipoxygenase, an enzyme This set index page lists enzyme...
    446 bytes (49 words) - 15:14, 5 February 2015
  • Thumbnail for 5-Oxo-eicosatetraenoic acid
    activated arachidonate 5-lipoxygenase (ALOX5) to form 5(S)-hydroperoxy-6E,8Z,11Z,14Z-eicosatetraenoic acid (5(S)-HpETE); c) reduction of this 5(S)-HpETE...
    34 KB (4,378 words) - 00:56, 27 February 2025
  • Thumbnail for Holger Stark
    (such as monoamine oxidase and cholinesterase), cyclooxygenase, arachidonate-5-lipoxygenase, and ion channels. Stark holds membership in several pharmaceutical...
    7 KB (720 words) - 03:27, 18 August 2024
  • Thumbnail for Arachidonic acid
    'peanut', although peanut oil does not contain any arachidonic acid. Arachidonate is the name of the derived carboxylate anion (conjugate base of the acid)...
    21 KB (1,892 words) - 21:24, 15 July 2025
  • Thumbnail for ALOX15B
    Arachidonate 15-lipoxygenase type II is an enzyme that in humans is encoded by the ALOX15B gene. ALOX15B, also known as 15-lipoxygenase-2 (15-LO-2 or...
    8 KB (1,036 words) - 03:50, 15 July 2025
  • Thumbnail for Leukotriene C4
    co-localization of cytosolic phospholipase A2 (cPLA2), arachidonate 5-lipoxygenase (5-LO), 5-lipoxygenase-activating protein (FLAP) and LTC4 synthase (LTC4S)...
    7 KB (563 words) - 02:22, 11 November 2023
  • Thumbnail for Chromosome 10
    protein Leukemia, acute lymphocytic, susceptibility to, 1 ALOX5: Arachidonate 5-Lipoxygenase (processes essential fatty acids to leukotrienes, which are important...
    29 KB (1,977 words) - 16:54, 16 July 2025
  • Thumbnail for Cysteinyl-leukotriene type 1 receptor antagonists
    to montelukast, zafirlukast and pranlukast. Antileukotriene Arachidonate 5-lipoxygenase inhibitor Antihistamines Hooper NM (2013). Membrane dipeptidase...
    19 KB (1,866 words) - 20:31, 29 May 2025
  • Thumbnail for ALOX12B
    Arachidonate 12-lipoxygenase, 12R type, also known as ALOX12B, 12R-LOX, and arachidonate lipoxygenase 3, is a lipoxygenase-type enzyme composed of 701...
    14 KB (1,713 words) - 03:50, 15 July 2025
  • medications or herbal agents such as skull cap or green tea. Arachidonate 5-lipoxygenase "Flavocoxid". livertox.nlm.nih.gov. Archived from the original...
    4 KB (556 words) - 13:52, 15 April 2024
  • 13.11.31: arachidonate 12-lipoxygenase EC 1.13.11.32: Now EC 1.13.12.16, nitronate monooxygenase EC 1.13.11.33: arachidonate 15-lipoxygenase EC 1.13.11...
    199 KB (24,465 words) - 11:27, 23 June 2025
  • Thumbnail for 13-Hydroxyoctadecadienoic acid
    Hartmut; Walther, Matthias; Kuban, Ralf Jürgen (2002). "Mammalian arachidonate 15-lipoxygenases". Prostaglandins & Other Lipid Mediators. 68–69: 263–290. doi:10...
    67 KB (7,853 words) - 21:38, 20 April 2025
  • Thumbnail for GRB2
    Gab-1. Grb2 has been shown to interact with: ADAM15, Abl gene, Arachidonate 5-lipoxygenase, B-cell linker, BCAR1, BCR gene, Beta-2 adrenergic receptor,...
    82 KB (9,409 words) - 01:43, 19 July 2025
  • Thumbnail for Oxoeicosanoid receptor 1
    6817–9. PMID 12460891. Ghosh J, Myers CE (1998). "Inhibition of arachidonate 5-lipoxygenase triggers massive apoptosis in human prostate cancer cells". Proc...
    26 KB (3,256 words) - 06:49, 19 July 2025
  • Thumbnail for Hepoxilin
    14Z-eicosatetraenoic acid) and concurrently the 11Z double bond in this arachidonate moves to the 10E position to form the intermediate product, 12S-hydroperoxy-5Z...
    34 KB (3,965 words) - 03:36, 16 January 2025
  • Thumbnail for ALOXE3
    of Medicine. "Entrez Gene: ALOXE3 arachidonate lipoxygenase 3". Schneider C, Brash AR (August 2002). "Lipoxygenase-catalyzed formation of R-configuration...
    20 KB (2,601 words) - 15:36, 17 July 2025
  • Thumbnail for 12-Hydroxyeicosatetraenoic acid
    responses to disturbances. In humans, arachidonate 12-lipoxygenase (12-LO, 12-LOX, ALO12, or platelet type 12-lipoxygenase) is encoded by the ALOX12 gene and...
    63 KB (6,990 words) - 02:05, 16 June 2025