A DNA-binding domain (DBD) is an independently folded protein domain that contains at least one structural motif that recognizes double- or single-stranded...

genetic information from DNA to RNA) to specific genes. A defining feature of TFs is that they contain at least one DNA-binding domain (DBD), which attaches...

DNA-binding proteins are proteins that have DNA-binding domains and thus have a specific or general affinity for single- or double-stranded DNA. Sequence-specific...

molecular biology, binding domain is a protein domain which binds to a specific atom or molecule, such as calcium or DNA. A protein domain is a part of a...

various binding modes in vivo. SSB protein domains in bacteria are important in its function of maintaining DNA metabolism, more specifically DNA replication...

a DNA-binding domain and a regulatory domain, also known as an effector domain or modulatory domain. The DNA-binding domain targets a specific DNA sequence...

individual zinc finger domains typically occur as tandem repeats with two, three, or more fingers comprising the DNA-binding domain of the protein. These...

(F) C-terminal domain: Highly variable in sequence between various nuclear receptors. The DNA-binding (C), and ligand binding (E) domains are independently...

N-terminal DNA-binding domain and a non sequence-specific DNA cleavage domain at the C-terminal. Once the protein is bound to duplex DNA via its DNA-binding domain...

"activating region" or "activation domain". Most activators function by binding sequence-specifically to a regulatory DNA site located near a promoter and...

"Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray...

Domain (bZIP domain) is found in many DNA binding eukaryotic proteins. One part of the domain contains a region that mediates sequence specific DNA binding...

Helix-turn-helix is a DNA-binding domain (DBD). The helix-turn-helix (HTH) is a major structural motif capable of binding DNA. Each monomer incorporates...

protein contains three domains, an N-terminal DNA-binding domain, a central transcriptional activation domain and a C-terminal domain involved in transcriptional...

factors that have well-conserved homeodomains. The Pou domain is a bipartite DNA binding domain found in these proteins. The acronym POU is derived from...

precise function of the protein domain SAND remains to be determined. Nevertheless, it is thought to be a DNA binding domain despite its beta structure. This...

is a method for identifying the sequence-specific target site of a DNA-binding domain. In this system, a given transcription factor (TF) is expressed as...

DNA binding sites are a type of binding site found in DNA where other molecules may bind. DNA binding sites are distinct from other binding sites in that...

fusing a zinc finger DNA-binding domain to a DNA-cleavage domain. Zinc finger domains can be engineered to target specific desired DNA sequences and this...

repressor (LacI) operates by a helix-turn-helix motif in its DNA-binding domain, binding base-specifically to the major groove of the operator region...

DNA-binding domain and a dimerization domain. The dimerization domain binds to other LexA polypeptides to form dumbbell shaped dimers. The DNA-binding domain is...

recognition of target genomic loci and binding of effector DNA-binding domain (DBD), double-strand breaks (DSBs) in target DNA by the restriction endonucleases...

a DNA binding domain that target specific sequences and an effector domain that modifies epigenomic features. Currently, three major groups of DNA binding...

by the CXXC1 gene. Proteins that contain a CXXC motif within their DNA-binding domain, such as CXXC1, recognize CpG sequences and regulate gene expression...

which must comprise a DNA-binding domain to give sequence specificity and a nuclease domain for DNA cleavage. DNA-binding domains including the basic helix-loop-helix...

in the DNA. A Z-DNA high affinity binding protein, hZαADAR1, was used at varying concentrations to induce the transformation from B-DNA to Z-DNA. The smFRET...

C-terminal domain (residues 434–581) is responsible for the noncovalent binding of DnaG to the DnaB helicase protein. The zinc-binding domain, the domain responsible...

as a Q-linker. The C-Terminal domain, also known as the DNA Binding Domain (DBD), shows high affinity for regions in DNA that are rich in Adenine and Thymine...

the DNA-binding motifs for recognition of the direct repeats (DRs), was restored in steps 5->8. The last two steps restored the catalytic domain, which...

metabolism. Human HSF1 consists of several domains which regulate its binding and activity. This N-terminal domain of approximately 100 amino acids is the...