The norepinephrine transporter (NET), also known as noradrenaline transporter (NAT), is a protein that in humans is encoded by the solute carrier family...
33 KB (3,478 words) - 15:43, 11 January 2025
competitively and/or noncompetitively inhibiting the norepinephrine transporter (NET) and dopamine transporter (DAT). NDRIs are used clinically in the treatment...
5 KB (463 words) - 05:51, 28 January 2025
depression and attention deficit hyperactivity disorder (ADHD). The norepinephrine transporter (NET) serves as the fundamental mechanism for the inactivation...
34 KB (3,816 words) - 22:08, 29 May 2025
three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the...
21 KB (2,342 words) - 15:34, 14 September 2024
neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline) by blocking the action of the norepinephrine transporter (NET). This in turn...
7 KB (678 words) - 15:01, 12 December 2024
inhibitors (SSRIs) and norepinephrine reuptake inhibitors (NRIs), which act upon single neurotransmitters. The human serotonin transporter (SERT) and noradrenaline...
84 KB (8,214 words) - 15:24, 9 June 2025
cortex, where evidence points to a possibly larger role of the norepinephrine transporter. DAT is implicated in a number of dopamine-related disorders,...
84 KB (9,204 words) - 02:53, 2 June 2025
Dopamine reuptake inhibitor (redirect from Dopamine transporter "inverse agonist")
very selective for the dopamine transporter, with little to no effect on the norepinephrine and serotonin transporters 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl...
19 KB (1,930 words) - 22:33, 23 May 2025
Norepinephrine (NE), also called noradrenaline (NA) or noradrenalin, is an organic chemical in the catecholamine family that functions in the brain and...
60 KB (6,685 words) - 12:18, 31 May 2025
epinephrine and norepinephrine; subtypes include α1, α2, β1, β2, and β3 receptors Adrenergic transporter (norepinephrine transporter), a protein transporting...
3 KB (286 words) - 18:10, 25 July 2024
proteins for monoamines (i.e., the dopamine transporter, norepinephrine transporter, and serotonin transporter) in monoamine neurons. Other VMAT2 inhibitors...
29 KB (3,347 words) - 14:46, 25 May 2025
simultaneous inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively, increasing their...
142 KB (16,594 words) - 16:53, 5 June 2025
exceptionally difficult to tease apart affinity for the DAT from the norepinephrine transporter (NET) and inhibit the reuptake of dopamine alone. As a result...
16 KB (1,791 words) - 22:09, 29 May 2025
A norepinephrine releasing agent (NRA), also known as an adrenergic releasing agent, is a catecholaminergic type of drug that induces the release of norepinephrine...
18 KB (1,747 words) - 15:13, 13 February 2025
autonomic cardiac neuropathy, although reduced expression of the norepinephrine transporter may also result in impaired MIBG reuptake and has been implicated...
99 KB (9,955 words) - 04:57, 6 June 2025
(MATs), which include the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT). This in turn results in an increase...
20 KB (1,388 words) - 21:36, 30 January 2025
WY-46824 (category Norepinephrine–dopamine reuptake inhibitors)
of 46 nM for the norepinephrine transporter (NET), 58 nM for the dopamine transporter (DAT), and 18795 nM for the serotonin transporter (SERT). The racemic...
3 KB (195 words) - 15:43, 11 January 2025
inhibit serotonin transporter (SERT) in the brain and have negligible effects on dopamine transporter (DAT) and norepinephrine transporter (NET). Inhibiting...
51 KB (5,336 words) - 14:09, 1 April 2025
inhibits serotonin transporter (SERT) and norepinephrine transporter (NET). It is metabolized to nortriptyline, a stronger norepinephrine reuptake inhibitor...
93 KB (8,721 words) - 15:38, 11 June 2025
Atomoxetine (category Serotonin–norepinephrine reuptake inhibitors)
Atomoxetine, formerly sold under the brand name Strattera, is a selective norepinephrine reuptake inhibitor (sNRI) medication used to treat attention deficit...
72 KB (6,260 words) - 04:34, 5 June 2025
selectivity for the dopamine transporter (DAT) relative to the serotonin transporter (SERT) and the norepinephrine transporter (NET). Vanoxerine GBR-12935...
4 KB (293 words) - 15:39, 10 June 2025
and pinoxepin. Further work on these compounds led to tametraline, a norepinephrine and weaker dopamine reuptake inhibitor. Development of tametraline was...
105 KB (10,802 words) - 18:22, 11 June 2025
The serotonin transporter (SERT or 5-HTT) also known as the sodium-dependent serotonin transporter and solute carrier family 6 member 4 is a protein that...
31 KB (3,442 words) - 04:14, 20 May 2025
transports monoamine neurotransmitters – such as dopamine, serotonin, norepinephrine, epinephrine, and histamine – into the vesicles, which release the neurotransmitters...
43 KB (4,993 words) - 04:26, 10 March 2025
the monoamine transporters (MATs), including the serotonin transporter (SERT), norepinephrine transporter (NET), and/or dopamine transporter (DAT), causing...
262 KB (22,099 words) - 16:54, 8 June 2025
JZ-IV-10 (category Serotonin–norepinephrine–dopamine reuptake inhibitors)
piperidine-based monoamine transporter inhibitors: effects of piperidine ring stereochemistry on potency. Identification of norepinephrine transporter selective ligands...
4 KB (193 words) - 09:57, 20 September 2024
methylphenidate lose their ability to elevate brain dopamine but not norepinephrine in dopamine transporter (DAT) knockout mice and have been found to decrease locomotor...
114 KB (12,382 words) - 04:41, 2 June 2025
concentration) at the monoamine transporters are 227 nM at the dopamine transporter (DAT), 11,970 nM at the norepinephrine transporter (NET) (53-fold lower), and...
9 KB (884 words) - 07:19, 20 February 2025
in vitro inhibitory effects of propofol and ketamine on norepinephrine and serotonin transporter function". J Clin Neurosci. 15 (11): 1264–9. doi:10.1016/j...
119 KB (11,478 words) - 03:09, 13 June 2025
Reboxetine (category Norepinephrine reuptake inhibitors)
fairly selective norepinephrine reuptake inhibitor (NRI), with approximately 20-fold selectivity for the norepinephrine transporter (NET) over the serotonin...
29 KB (2,701 words) - 14:51, 18 April 2025