Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for...
55 KB (6,180 words) - 10:18, 9 May 2025
polymerase α, DNA polymerase ε, replication protein A (RPA) and proliferating cell nuclear antigen (PCNA) onto chromatin. Within a Xenopus nucleus-free system...
121 KB (14,916 words) - 04:06, 3 January 2025
Antinuclear antibody (redirect from Anti-nuclear antibody)
bind to contents of the cell nucleus. In normal individuals, the immune system produces antibodies to foreign proteins (antigens) but not to human proteins...
55 KB (6,260 words) - 02:26, 24 February 2025
Kathleen M, So Antero G (Jul 2002). "Direct interaction of proliferating cell nuclear antigen with the small subunit of DNA polymerase delta". J. Biol....
8 KB (899 words) - 17:43, 23 March 2024
from a specific subunit of DNA polymerase delta called the proliferating cell nuclear antigen (PCNA). The N-terminal and C-terminal domains of PCNA are...
23 KB (2,044 words) - 07:04, 10 March 2024
Ki-67 (protein) (redirect from Ki-67 antigen)
Ki-67 (protein) has been shown to interact with CBX3. PCNA - Proliferating Cell Nuclear Antigen, expressed during the DNA synthesis. Immunofluorescent antibody...
10 KB (1,365 words) - 02:06, 17 June 2024
for RFC-dependent loading of the replication sliding clamp, proliferating cell nuclear antigen (PCNA), in an orientation-specific manner, such that one face...
37 KB (4,458 words) - 00:33, 14 May 2025
anticancer medication which acts as a small molecule inhibitor of proliferating cell nuclear antigen (PCNA) and is in Phase I clinical trials at City of Hope as...
6 KB (589 words) - 21:09, 7 January 2025
"Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry...
23 KB (2,642 words) - 21:34, 20 February 2024
failures could be lethal to the cell. Further research implicates the supplementary role of proliferating cell nuclear antigen (PCNA) to DNA ligase I's function...
34 KB (4,470 words) - 07:49, 11 November 2024
DNA repair (section Nuclear versus mitochondrial)
polymerases. A bypass platform is provided to these polymerases by Proliferating cell nuclear antigen (PCNA). Under normal circumstances, PCNA bound to polymerases...
132 KB (16,176 words) - 11:20, 23 April 2025
Conversion from mitosis to meiosis: morphology and expression of proliferating cell nuclear antigen (PCNA) and Dmc1 during newt spermatogenesis. Dev Growth Differ...
36 KB (3,835 words) - 03:38, 1 February 2025
P21 (category Cell cycle regulators)
activity via ubiquitin ligase activity. p21 interacts with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory...
34 KB (3,939 words) - 06:53, 4 May 2025
P53 (redirect from Antigen NY-CO-13)
Prosperi E (December 2001). "UV-induced DNA incision and proliferating cell nuclear antigen recruitment to repair sites occur independently of p53-replication...
131 KB (14,361 words) - 00:12, 13 May 2025
exhibits increased processivity when interacting with the proliferating cell nuclear antigen (PCNA). As well, the multisubunit protein replication factor...
2 KB (259 words) - 21:21, 11 December 2023
strand by PCNA (Proliferating Cell Nuclear Antigen). PCNA forms typical patterns in the nucleus of the cell through which the current cell cycle can be determined...
9 KB (1,265 words) - 11:50, 29 October 2024
negatively regulated by direct interaction with proliferating cell nuclear antigen". Genes to Cells. 6 (9): 815–24. doi:10.1046/j.1365-2443.2001.00460...
30 KB (3,557 words) - 05:39, 17 August 2024
polymerase lambda functionally and physically interacts with proliferating cell nuclear antigen in normal and translesion DNA synthesis". J. Biol. Chem. 277...
9 KB (1,140 words) - 03:54, 24 February 2025
Epstein–Barr virus (redirect from EBV nuclear antigen)
Human-leukocyte-antigen class II molecules present in B cells in the endoplasmic reticulum and are degraded. In contrast, EBV from epithelial cells are rich...
65 KB (6,797 words) - 00:10, 20 May 2025
Similarly, proliferating cell nuclear antigen (PCNA) is a protein associated with cell proliferation that is upregulated in proliferating cells, making it...
13 KB (1,559 words) - 06:51, 1 January 2025
Koundrioukoff S, Christensen J, Hughes P (Dec 2001). "Mediation of proliferating cell nuclear antigen (PCNA)-dependent DNA replication through a conserved p21(Cip1)-like...
6 KB (740 words) - 17:22, 3 December 2023
failure in humans is coupled with the induction of proliferating cell nuclear antigen and nuclear mitotic division in ventricular myocytes. Circ Res 1994;75:1050–1063...
6 KB (921 words) - 12:20, 25 March 2022
Chromatin assembly factor 1 (category Induced stem cells)
studies have shown that the interaction between CAF-1 and PCNA (proliferating cell nuclear antigen, which stabilizes CAF-1 at replication forks, is important...
10 KB (1,163 words) - 04:04, 9 February 2025
"Interaction of human AP endonuclease 1 with flap endonuclease 1 and proliferating cell nuclear antigen involved in long-patch base excision repair". Biochemistry...
11 KB (1,319 words) - 18:41, 13 August 2023
anti-proliferating cell nuclear antigen (PCNA) murine monoclonal antibodies and human autoantibodies to the PCNA multiprotein complexes involved in cell proliferation"...
14 KB (1,658 words) - 17:06, 27 August 2024
somatic cells, localizes to replication foci, has a 10–40-fold preference for hemimethylated DNA and interacts with the proliferating cell nuclear antigen (PCNA)...
159 KB (18,196 words) - 23:55, 9 May 2025
Xiong Y (Feb 2006). "An evolutionarily conserved function of proliferating cell nuclear antigen for Cdt1 degradation by the Cul4-Ddb1 ubiquitin ligase in...
36 KB (4,418 words) - 04:39, 25 December 2024
2002). "A proteomics approach to identify proliferating cell nuclear antigen (PCNA)-binding proteins in human cell lysates. Identification of the human CHL12/RFCs2-5...
19 KB (2,249 words) - 23:19, 9 September 2023
reassociate with the DNA. An example of such a DNA clamp is PCNA (proliferating cell nuclear antigen) found in S. cervesiae. Multiple DNA polymerases have specialized...
6 KB (826 words) - 20:25, 10 September 2023
synthesis by DNA polymerase epsilon in the presence of PCNA (proliferating cell nuclear antigen), RFC (replication factor C) and RPA (replication protein...
3 KB (336 words) - 03:59, 2 December 2024