Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the SrcA subfamily, Lck, Hck...
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Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src, or simply c-Src (cellular Src; pronounced "sarc", as it is short for sarcoma)...
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C-terminal end of Src-family kinases (SFKs) including SRC, HCK, FYN, LCK, LYN and YES1. This Non-receptor tyrosine-protein kinase plays an important...
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LYN (redirect from Lyn (Src family kinase))
Tyrosine-protein kinase Lyn is a protein that in humans is encoded by the LYN gene. Lyn is a member of the Src family of protein tyrosine kinases, which is mainly...
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2009). "CD45, CD148, and Lyp/Pep: critical phosphatases regulating Src family kinase signaling networks in immune cells". Immunological Reviews. 228 (1):...
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sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase...
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constitutive activation of downstream signaling molecules such as Src-family kinases.[citation needed] CML has a well defined molecular target and relatively...
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HCK (category Tyrosine kinases)
Moarefi I, Kuriyan J (February 1997). "Crystal structure of the Src family tyrosine kinase Hck". Nature. 385 (6617): 602–609. Bibcode:1997Natur.385..602S...
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domain. However, activation of SYK relies less on phosphorylation by Src family kinases than ZAP70. SYK and ZAP70 share a common evolutionary origin and split...
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and encoded in the human by the LCK gene. The Lck is a member of Src kinase family (SFK) and is important for the activation of T-cell receptor (TCR)...
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a type of kinase in the Src family that was identified in the nuclear matrix, appears to control the cell cycle. Src family tyrosine kinases are closely...
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in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck (IC50=4 nM), Fyn (5 nM) and Hck (5 nM), shows...
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locomotive built in 1897 for the Lynton and Barnstaple Railway Lyn (Src family kinase), in biochemistry LyN, a video game engine Lyn Me, a character in...
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In some cases PTPs positively regulate nRTKs activity. Tyrosine kinases of Src family contain the same typical structure: myristoylated terminus, a region...
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Non-catalytic tyrosine-phosphorylated receptor (redirect from NTR receptor family)
tyrosine-phosphorylated receptors (NTRs), also called immunoreceptors or Src-family kinase-dependent receptors, are a group of cell surface receptors expressed...
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kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. It is of the Src family of...
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amino acid sequence similarity to Csk tyrosine kinase and has the structural features of the CSK subfamily: SRC homology SH2 and SH3 domains, a catalytic domain...
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FYN (category Tyrosine kinases)
tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded by the FYN gene. Fyn is a 59-kDa member of the Src family...
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Autophosphorylation (section Src kinases)
intracellular domain is a tyrosine kinase that phosphorylates its partner in the receptor. The Src-family kinases are examples of proteins that utilize...
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Saracatinib (category Non-receptor tyrosine kinase inhibitors)
AstraZeneca. It acts as a dual kinase inhibitor, with selective actions as a Src inhibitor and a Bcr-Abl tyrosine-kinase inhibitor. It was originally under...
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SK, Henriksen KJ, Long CG, Vives F, Bluestone JA (May 2002). "The Src family kinase Fyn mediates signals induced by TCR antagonists". Journal of Immunology...
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CD94/NKG2 (section CD94/NKG2 family)
(D/E)xxYxx(L/I)x6-8Yxx(L/I)). Src family kinases phosphorylate tyrosine in ITAM sequence. It results in recruitment of tyrosine kinases Syk and ZAP-70 by the...
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DT (April 1994). "Cloning of FRK, a novel human intracellular SRC-like tyrosine kinase-encoding gene". Gene. 138 (1–2): 247–51. doi:10.1016/0378-1119(94)90817-6...
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PRL-R). The distinguishing feature between janus kinase 2 and other JAK kinases is the lack of Src homology binding domains (SH2/SH3) and the presence...
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coppice, an energy crop Src (gene), a family of proto-oncogenic tyrosine kinases SRC, the human orthologue of the Src gene SRC Computers, a company founded...
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PTK2 (redirect from PTK2 protein tyrosine kinase 2)
non-receptor tyrosine kinase originally identified as a substrate for the oncogene protein tyrosine kinase v-src. This cytosolic kinase has been implicated...
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SU6656 (category Protein kinase inhibitors)
SU6656 is a Src family kinase inhibitor developed by the biotechnology company SUGEN Inc (a subsidiary of Pharmacia) in 2000. SU6656 was initially identified...
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Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine kinases that transduce cytokine-mediated signals via the JAK-STAT pathway. They...
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PMID 15122207. S2CID 6939454. Summy JM, Gallick GE (December 2003). "Src family kinases in tumor progression and metastasis". Cancer and Metastasis Reviews...
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ABL (gene) (category Tyrosine kinases)
K, Emmerich B, Hallek M (December 1997). "The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding...
30 KB (3,496 words) - 23:38, 3 March 2024