= 98% E-6837 – Full agonist at human 5HT6 receptors E-6801 E-6837 – partial agonist at rat 5-HT6 receptors. Orally active in rats, and caused weight loss...
29 KB (3,306 words) - 05:19, 25 May 2025
a 5-HT5A receptor agonist, and this action could be involved in the sleep-promoting effects of valerian. No selective agonists of the 5-HT6 receptor have...
16 KB (1,664 words) - 07:32, 20 February 2025
which activates 5-HT1A, 5-HT1D, 5-HT1B, D2 and norepinephrine receptors. LSD (a psychedelic) is a 5-HT1A, 5-HT2A, 5-HT2C, 5-HT5A and 5-HT6 agonist. The genes...
65 KB (5,273 words) - 08:55, 28 May 2025
5-HT2A receptor 5-HT2B receptor 5-HT2C receptor 5-HT1 receptor 5-HT3 receptor 5-HT4 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7 receptor Category:5-HT2...
2 KB (166 words) - 00:47, 13 May 2022
of 5-HT3 receptors in cell lines and native tissues quickly followed. 5-HT1 receptor 5-HT2 receptor 5-HT4 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7...
23 KB (2,440 words) - 22:20, 30 May 2025
articles of the individual subtypes: 5-HT2 receptor 5-HT3 receptor 5-HT4 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7 receptor Hoyer D, Clarke DE, Fozard JR...
5 KB (472 words) - 15:42, 23 May 2025
Chamomile (ethanol extract) 5-HT receptor 5-HT1 receptor 5-HT2 receptor 5-HT3 receptor 5-HT5 receptor 5-HT6 receptor 5-HT7 receptor GRCh38: Ensembl release...
18 KB (2,096 words) - 04:06, 20 May 2025
206 nM affinity. SB-699,551 5-HT receptor 5-HT1 receptor 5-HT2 receptor 5-HT3 receptor 5-HT4 receptor 5-HT6 receptor 5-HT7 receptor GRCh38: Ensembl release...
16 KB (1,773 words) - 06:08, 29 April 2025
Paliperidone Risperidone 5-HT receptor 5-HT1 receptor 5-HT2 receptor 5-HT3 receptor 5-HT4 receptor 5-HT5 receptor 5-HT6 receptor GRCh38: Ensembl release...
26 KB (3,078 words) - 21:46, 20 May 2025
5-Benzyloxytryptamine (5-BT), is a tryptamine derivative which acts as an agonist at the 5-HT1D, 5-HT2 and 5-HT6 serotonin receptors, and an antagonist...
4 KB (260 words) - 17:22, 27 March 2025
SB-271046 (category 5-HT6 antagonists)
5-HT6 receptor antagonists to be discovered, and was found through high-throughput screening of the SmithKline Beecham Compound Bank using cloned 5-HT6...
8 KB (730 words) - 19:22, 18 June 2025
the treatment of agitation in Alzheimer's dementia. It is a selective 5-HT6 receptor antagonist. "Masupirdine - Suven Life Sciences". AdisInsight. Springer...
2 KB (80 words) - 04:45, 24 February 2025
SB-357134 (category 5-HT6 antagonists)
It acts as a potent, selective and orally active 5-HT6 receptor antagonist. SB-357134 and other 5-HT6 antagonists show nootropic effects in animal studies...
4 KB (250 words) - 11:12, 6 November 2024
EMDT (redirect from 2-Ethyl-5-methoxy-N,N-dimethyltryptamine)
acts as a selective 5-HT6 receptor agonist, with a Ki of 16 nM, and was one of the first selective agonists developed for this receptor. Its affinities for...
4 KB (289 words) - 07:15, 12 April 2025
receptor (or 5-HT1A receptor) is a subtype of serotonin receptors, or 5-HT receptors, that binds serotonin, also known as 5-HT, a neurotransmitter. 5-HT1A...
59 KB (6,182 words) - 23:06, 22 May 2025
ASR-3001 (redirect from 5-methoxy-N-allyl-N-isopropyltryptamine)
serotonin 5-HT2A receptor, 46.8 nM at the serotonin 5-HT1B receptor, 87.4 nM at the serotonin 5-HT2B receptor, 420 nM at the serotonin 5-HT6 receptor, and...
9 KB (730 words) - 04:21, 19 May 2025
Hypidone (category 5-HT6 agonists)
disorder. It acts as a serotonin reuptake inhibitor, 5-HT1A receptor partial agonist, and 5-HT6 receptor full agonist. It is used as the hydrochloride salt...
6 KB (306 words) - 20:52, 5 April 2024
PRX-07034—5-HT6 receptor antagonist: for obesity and cognitive impairment associated with Alzheimer's disease and schizophrenia PRX-08066—5-HT2B receptor antagonist:...
2 KB (137 words) - 02:14, 9 September 2024
WAY-208466 (category 5-HT6 agonists)
WAY-208466 is a potent and highly selective full agonist of the 5-HT6 receptor. It increases GABA levels in the cerebral cortex and tolerance does not...
2 KB (141 words) - 12:32, 5 September 2024
identified as serotonin 5-HT1D receptor ligands, serotonin 5-HT6 receptor partial agonists, and/or serotonin 5-HT7 receptor inverse agonists. These actions...
19 KB (1,077 words) - 14:55, 31 May 2025
The 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and functions as a G protein-coupled receptor (GPCR)...
131 KB (13,680 words) - 11:36, 9 June 2025
ABT-354 (category 5-HT6 antagonists)
developed by AbbVie, Inc. as a selective antagonist of the serotonin 5-HT6 receptor (HTR6), with intended applications in the treatment of cognitive disorders...
8 KB (466 words) - 09:47, 1 June 2025
other actions) Masupirdine (SUVN-502) – 5-HT6 receptor antagonist N-Methylamisulpride (LB-102) – D2,3, 5-HT7, receptor antagonist (methylated version of amisulpride)...
10 KB (746 words) - 22:51, 27 February 2025
Cyclobenzaprine (category 5-HT6 antagonists)
serotonin 5-HT2A, 5-HT2B, 5-HT2C, 5-HT6, and 5-HT7 receptor antagonism, α1- and α2-adrenergic receptor antagonism, histamine H1 receptor noncompetitive...
31 KB (2,421 words) - 23:46, 21 June 2025
SB-399885 (category 5-HT6 antagonists)
a potent, selective and orally active 5-HT6 receptor antagonist, with a Ki of 9.0nM. SB-399885 and other 5-HT6 antagonists show nootropic effects in animal...
5 KB (365 words) - 17:16, 21 January 2025
E-6801 (category 5-HT6 agonists)
E-6801 is a partial agonist of the 5-HT6 receptor. It enhanced recognition memory and reversed the memory deficits of scopolamine in an object recognition...
2 KB (130 words) - 07:56, 27 March 2025
WAY-181187 (category 5-HT6 agonists)
WAY-181187 is a high affinity and selective 5-HT6 receptor full agonist. It induces robust increases in extracellular GABA levels in the frontal cortex...
4 KB (299 words) - 21:00, 1 December 2023
MS-245 (category 5-HT6 antagonists)
selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT6 agonist...
4 KB (299 words) - 17:23, 27 March 2025
2-Methyltryptamines like 5-MeO-TMT show a loss of affinity for the serotonin 5-HT2A receptor but retained affinity for the serotonin 5-HT6 receptor. It also retains...
12 KB (871 words) - 19:53, 25 May 2025
The 5-HT2C receptor is a subtype of the 5-HT2 receptor that binds the endogenous neurotransmitter serotonin (5-hydroxytryptamine, 5-HT). Like all 5-HT2...
51 KB (6,133 words) - 17:35, 28 May 2025