protein 1 (AP-1) is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors, stress...
42 KB (4,614 words) - 14:25, 30 July 2025
Transcription factor Jun is a protein that in humans is encoded by the JUN gene. c-Jun, in combination with protein c-Fos, forms the AP-1 early response...
46 KB (5,537 words) - 04:52, 15 July 2025
molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information...
75 KB (8,351 words) - 22:53, 24 June 2025
The AP-1 binding site, also known as the AP-1 promoter site, is a DNA sequence to which AP-1 transcription factors are able to bind. The AP-1 binding...
982 bytes (113 words) - 15:58, 19 September 2022
JunD (category Transcription factors)
with ATF3, MEN1, DNA damage-inducible transcript 3 and BRCA1. AP-1 (transcription factor) GRCh38: Ensembl release 89: ENSG00000130522 – Ensembl, May 2017...
13 KB (1,561 words) - 17:05, 17 July 2025
JNK is phosphorylated, which leads to the phosphorylation of AP-1 (transcription factor consisting of cFOS and Cjun). This results in the activation of...
8 KB (935 words) - 04:17, 28 May 2025
JUNB (category Transcription factors)
growth factor response. It binds to the DNA sequence 5'-TGA[CG]TCA-3'. JUNB has been shown to interact with BRCA1, and SMAD3. AP-1 (transcription factor) GRCh38:...
9 KB (1,199 words) - 04:20, 15 July 2025
BATF (gene) (category Transcription factors)
basic leucine zipper (bZIP) protein that belongs to the AP-1/ATF superfamily of transcription factors. The leucine zipper of this protein mediates dimerization...
7 KB (885 words) - 15:47, 17 July 2025
SV40 (redirect from Macaca mulatta polyomavirus 1)
of synthesis. This is done by binding (dimerization) with the AP-1 transcription factor to give a primary transcript that is 3' polyadenylated and 5'...
21 KB (2,522 words) - 18:30, 17 July 2025
ATF1 (redirect from Activating transcription factor 1)
AMP-dependent transcription factor ATF-1 is a protein that in humans is encoded by the ATF1 gene. This gene encodes an activating transcription factor, which...
11 KB (1,380 words) - 03:53, 15 July 2025
Lithium (medication) (section Neurotrophic factors)
mesencephalic astrocyte-derived neurotrophic factor (MANF), another neurotrophic factor, via the AP-1 transcription factor. MANF is able to regulate proteostasis...
105 KB (11,204 words) - 21:56, 15 July 2025
Psychiatry. 27 (1): 624–639. doi:10.1038/s41380-021-01256-1. PMC 8960411. PMID 34453125. Hope BT (May 1998). "Cocaine and the AP-1 transcription factor complex"...
201 KB (20,633 words) - 06:04, 25 July 2025
Activating transcription factor, ATF, is a group of bZIP transcription factors, which act as homodimers or heterodimers with a range of other bZIP factors. First...
3 KB (310 words) - 08:38, 6 November 2024
USF1 (redirect from Upstream Transcription Factor 1)
stimulatory factor 1 is a protein that in humans is encoded by the USF1 gene. The upstream stimulatory factor (USF) gene encodes a transcription factor USF that...
41 KB (4,563 words) - 09:19, 18 July 2025
FOSL2 (category Transcription factors)
dimerize with proteins of the JUN family, thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators...
5 KB (676 words) - 05:50, 19 July 2025
FOSB (category Transcription factors)
of the JUN family (e.g., c-Jun, JunD), thereby forming the transcription factor complex AP-1. As such, the FOS proteins have been implicated as regulators...
57 KB (7,191 words) - 16:36, 17 July 2025
Transcription factor Sp1, also known as specificity protein 1* is a protein that in humans is encoded by the SP1 gene. The protein encoded by this gene...
30 KB (3,441 words) - 08:44, 5 February 2025
ATF/CREB (category Transcription factors)
the transcription factors assigned to this group, some are more related to CREB-like, factors, whereas other exhibit closer similarity with the AP-1 transcription...
2 KB (225 words) - 20:32, 13 October 2022
This list of manually curated human transcription factors is taken from Lambert, Jolma, Campitelli et al. It was assembled by manual curation. More detailed...
374 KB (81 words) - 11:17, 3 January 2025
BZIP domain (section bZIP transcription factors)
factors affecting reproductive functions, and several other phenomena that affect human health. AP-1 fos/jun heterodimer that forms a transcription factor...
7 KB (663 words) - 00:42, 13 March 2024
Protein c-Fos (category Transcription factors)
(part of Jun family of transcription factors), resulting in the formation of AP-1 (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the...
26 KB (3,991 words) - 05:29, 10 July 2024
General transcription factors (GTFs), also known as basal transcriptional factors, are a class of protein transcription factors that bind to specific...
12 KB (1,319 words) - 16:40, 17 July 2025
the -60 position. There are several AP-1 transcription factor binding sites in the viral LTRs. The closest AP-1 binding site is bound by the Jun and...
30 KB (3,765 words) - 07:43, 19 July 2025
T-box transcription factor T, also known as Brachyury protein, is encoded for in humans and other apes by the TBXT gene. Brachyury functions as a transcription...
36 KB (4,178 words) - 20:39, 16 July 2025
1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene. Thyroid transcription factor-1...
19 KB (2,210 words) - 09:49, 18 July 2025
Transformation Specific) family is one of the largest families of transcription factors and is unique to animals. There are 28 genes in humans, 27 in the...
10 KB (1,058 words) - 23:17, 24 May 2025
Diagnostic Pathology. 33 (1): 50–9. doi:10.1053/j.semdp.2015.09.007. PMID 26490572. "FOS Fos proto-oncogene, AP-1 transcription factor subunit [Homo sapiens...
20 KB (2,282 words) - 13:50, 3 December 2023
The GATA transcription factor family consists of six DNA-binding proteins (GATA1-6) that regulates transcription of DNA due to their ability to bind to...
8 KB (995 words) - 06:20, 25 July 2024