L1, also known as L1CAM, is a transmembrane protein member of the L1 protein family, encoded by the L1CAM gene. This protein, of 200-220 kDa, is a neuronal...
33 KB (4,004 words) - 06:22, 27 May 2024
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by...
23 KB (2,846 words) - 01:03, 18 May 2024
sequences L1 family, a protein family of cell adhesion molecules L1 (protein), a cell adhesion molecule L1 or LINE1; transposable elements in the DNA L1, Lagrangian...
4 KB (662 words) - 17:05, 14 April 2024
and PD-L1 inhibitors are a group of checkpoint inhibitor anticancer drugs that block the activity of PD-1 and PDL1 immune checkpoint proteins present...
31 KB (3,266 words) - 05:29, 20 May 2024
immune responses. PD-1 has two ligands, PD-L1 and PD-L2, which are members of the B7 family. PD-L1 protein is upregulated on macrophages and dendritic...
39 KB (5,010 words) - 04:36, 6 May 2024
(accounts for 1-2% of total brain protein), expressed specifically in neurons and testis/ovary. The catalytic triad of UCH-L1 contains a cysteine at position...
21 KB (2,637 words) - 03:01, 26 November 2023
Papillomaviridae (redirect from E6 – protein)
host cell, and a late region (L) encoding a major capsid protein L1 and a minor capsid protein L2. All viral ORFs are encoded on one DNA strand (see figure)...
63 KB (7,242 words) - 05:09, 15 April 2024
The L1 family is a family of cell adhesion molecules that includes four different L1-like proteins. They are members of the immunoglobulin superfamily...
4 KB (500 words) - 17:23, 12 May 2024
cell adhesion molecule (sometimes called the L1 protein). The L1 cell adhesion molecule is a surface protein found on the surface of all neurons. It allows...
33 KB (3,549 words) - 03:26, 19 February 2024
genome, 360 L1 protein copies, and 12 copies of L2 proteins inside. L2 proteins gather at PML body nuclear structures and recruit L1 proteins during virus...
16 KB (1,944 words) - 09:51, 19 May 2024
LINE1 (category Protein pages needing a picture)
unknown function. The first ORF of L1 encodes a 500-amino acid, 40-kDa protein that lacks homology with any protein of known function. In vertebrates,...
25 KB (2,724 words) - 06:45, 14 May 2024
Cancer immunotherapy (section PD-L1 inhibitors)
transmembrane programmed cell death 1 protein (PDCD1, PD-1; also known as CD279) and its ligand, PD-1 ligand 1 (PD-L1, CD274). PD-L1 on the cell surface binds to...
90 KB (9,954 words) - 15:21, 4 June 2024
Apolipoprotein L1 is a protein that in humans is encoded by the APOL1 gene. Two transcript variants encoding two different isoforms have been found for...
24 KB (3,155 words) - 11:15, 25 January 2024
HPV vaccine (category Protein subunit vaccines)
Retrieved 3 April 2020. "Gardasil HPV 6 L1 Protein / HPV 11 L1 Protein / HPV 16 L1 Protein / HPV 18 L1 Protein 20,40,40,20 micrograms/0.5mL sterile liquid...
180 KB (17,202 words) - 15:28, 13 May 2024
Cervarix (category Protein subunit vaccines)
vaccine are: Human papillomavirus type 16 L1 protein 20 micrograms Human papillomavirus type 18 L1 protein 20 micrograms AS04 adjuvant, containing: 3-O-desacyl-4'-...
20 KB (1,789 words) - 18:59, 6 January 2024
(HPV), two late proteins are involved in capsid formation: a major (L1) and a minor (L2) protein, in the approximate proportion 95:5%. L1 forms a pentameric...
5 KB (490 words) - 00:54, 29 November 2023
39S ribosomal protein L1, mitochondrial is a protein that in humans is encoded by the MRPL1 gene. Mammalian mitochondrial ribosomal proteins are encoded...
5 KB (572 words) - 22:35, 3 March 2023
around 50–60 nm in diameter. The capsid is formed of the L1 and L2 structural proteins, with the L1 C-terminus exposed. All BPVs have a circular double-stranded...
17 KB (1,882 words) - 06:24, 12 September 2023
3T3-L1 is a sub clonal cell line derived from the original 3T3 Swiss albino cell line of 1962. The 3T3 original cell line was isolated from a mouse embryo...
17 KB (1,907 words) - 16:29, 3 June 2024
molecular chaperones are proteins that assist the conformational folding or unfolding of large proteins or macromolecular protein complexes. There are a...
29 KB (3,499 words) - 07:16, 20 February 2024
atrophic macular degeneration. This is because Alu elements undergo L1 (protein)-mediated reverse transcription in the cytoplasm resulting in DNA synthesis...
90 KB (9,840 words) - 07:29, 23 May 2024
programmed death cell ligand 1 (PD-L1) protein or BRCA gene mutation. Also known as immunotherapy the presence of PD-L1 on cancer cells mates with an associate...
28 KB (3,411 words) - 04:07, 14 March 2024
Virus-like particle (category Viral structural proteins)
the L1 proteins of HPV types 6, 11, 16, and 18 expressed in yeast. It is adjuvanted with aluminum hydroxyphosphate sulfate. Gardasil-9 consists of L1 epitopes...
22 KB (2,535 words) - 21:43, 4 May 2024
Protein folding is the physical process by which a protein, after synthesis by a ribosome as a linear chain of amino acids, changes from an unstable random...
76 KB (8,677 words) - 00:23, 28 May 2024
CKLF like MARVEL transmembrane domain containing 6 (category Human proteins)
cell PD-L1 protein located on cell surface membranes thereby maintaining PD-L1'S expression at this site; it also localizes with PD-L1 protein located...
11 KB (1,412 words) - 01:27, 20 August 2023
Durvalumab, (Imfinzi) is an immune checkpoint inhibitor that blocks the PD-L1 protein on the surface of immune cells, thereby allowing the immune system to...
74 KB (7,639 words) - 03:55, 13 January 2024
Cathepsin L1 is a protein that in humans is encoded by the CTSL1 gene. The protein is a cysteine cathepsin, a lysosomal cysteine protease that plays a...
14 KB (1,692 words) - 07:49, 8 March 2024
attachment to ribosomes that capture nascent L1 proteins. Thus, an Alu element can take control of the L1 protein's reverse transcriptase, ensuring that the...
27 KB (3,083 words) - 00:38, 2 June 2024
Retrotransposon (section Human L1)
transcriptase and protein rich in amino acids cysteines and histidines. The end of the human LINE1, as with other retrotransposons is adenine-rich. Human L1 actively...
24 KB (3,103 words) - 21:53, 3 May 2024
Protein targeting or protein sorting is the biological mechanism by which proteins are transported to their appropriate destinations within or outside...
52 KB (6,394 words) - 03:48, 19 March 2024