The Matrix-2 (M2) protein is a proton-selective viroporin, integral in the viral envelope of the influenza A virus. The channel itself is a homotetramer...
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Amantadine (category Proton channel blockers)
antiviral mechanism of action is inhibition of the influenza virus A M2 proton channel, which prevents endosomal escape (i.e., the release of viral genetic...
63 KB (6,152 words) - 16:18, 18 March 2025
RTI 2002 (FDA), 2003 (EU) Amantadine Influenza Influenza A virus M2 proton channel antagonist 1966 Ampligen Avian Influenza Immunomodulatory double-stranded...
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and influenza D virus), an endonuclease. The M1 matrix protein and M2 proton channel share a segment, as do the non-structural protein (NS1) and the nuclear...
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selectivity; examples include the influenza A virus M2 proton channel protein, which is highly selective for protons and is active at low pH, and the Chlorella...
20 KB (1,971 words) - 19:39, 18 March 2025
Rimantadine, which inhibit the uncoating of virions by interfering with M2 proton channel, and Oseltamivir (marketed under the brand name Tamiflu), Zanamivir...
39 KB (4,488 words) - 03:21, 20 March 2025
Electrochemical gradient (redirect from Proton gradient)
other transporters and ion channels play a role in generating a proton electrochemical gradient. One is TPK3, a potassium channel that is activated by Ca2+...
24 KB (2,768 words) - 18:02, 21 April 2025
Huang RB, Wang SQ, Chou KC (February 2010). "Designing inhibitors of M2 proton channel against H1N1 swine influenza virus". PLOS ONE. 5 (2): e9388. Bibcode:2010PLoSO...
82 KB (9,274 words) - 05:45, 1 May 2025
Rimantadine (category Proton channel blockers)
activity by binding to amino acids in the M2 transmembrane channel and blocking proton transport across the M2 channel. Rimantadine is believed to inhibit influenza's...
20 KB (1,857 words) - 23:15, 11 May 2025
Luo, W.; Hong, M. (2010-10-21). "Mechanisms of Proton Conduction and Gating in Influenza M2 Proton Channels from Solid-State NMR". Science. 330 (6003): 505–508...
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the head of those proteins were identified. The highly conserved M2 proton channel was proposed as a potential target for broadly neutralizing antibodies...
190 KB (18,986 words) - 17:49, 21 May 2025
effects of shoes Luca Turin Lymphocyte homing receptor M1 protein M2 proton channel MHC class I Magnesium transporter Magnetoception Magnetosome Magnetospirillum...
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PMID 29193965. Schnell, JR; Chou, JJ (2008). "Structure and mechanism of the M2 proton channel of influenza A virus". Nature. 451 (7178): 591–5. Bibcode:2008Natur...
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the smaller M2 proton channel protein, which is produced by RNA splicing. M2 protein is critical to the virus: it forms the ion channels that allow for...
7 KB (758 words) - 19:52, 6 September 2024
rises from the protonation of transmembrane helices at the end of the pore. At low pH, the M2 helix is protonated, shifting the ion channel from closed to...
28 KB (3,465 words) - 14:26, 27 March 2025
discovered. This protein family includes light-driven proton pumps, ion pumps and ion channels, as well as light sensors. For example, the proteins from...
33 KB (3,653 words) - 22:56, 18 March 2025
Bacteriorhodopsin (section M2 state → M2' state)
acts as a proton pump; that is, it captures light energy and uses it to move protons across the membrane out of the cell. The resulting proton gradient...
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protein in its metastable, pre-fusion conformation. Nature (2006) The M2 proton channels of influenza A and B viruses. Journal of Biological Chemistry (2006)...
11 KB (1,369 words) - 20:01, 16 September 2023
Aneutronic fusion (redirect from Proton–boron fusion)
aneutronic reactions release energy in the form of charged particles, typically protons or alpha particles. Successful aneutronic fusion would greatly reduce problems...
45 KB (5,639 words) - 01:45, 18 May 2025
Potassium channels are the most widely distributed type of ion channel found in virtually all organisms. They form potassium-selective pores that span...
57 KB (5,834 words) - 14:01, 24 February 2025
the same chemical element. They have the same atomic number (number of protons in their nuclei) and position in the periodic table (and hence belong to...
49 KB (6,012 words) - 17:52, 25 April 2025
Dimensions: 5.8 x 2.4 x 2.4 m and a 27 m2 solar array DC power: 120 W Expected lifetime: 12 years Transponders: 32 Vehicle: Proton-K / Blok DM3 Nimiq 2, launched...
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up to 5 GeV for kaon/proton discrimination. It is the world's largest caesium iodide RICH detector, with an active area of 11 m2. A prototype was successfully...
63 KB (8,746 words) - 15:06, 16 May 2025
Hyper-Kamiokande (section Proton decay)
increase the lower limit of the proton mean lifetime from 1.6 · 1034 to 6.3 · 1034 years for its most sensitive decay channel (p+ → e+ + π0 ) and from 0.7 · 1034...
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a subset of potassium channels in the heart, which, when activated by parasympathetic signals such as acetylcholine through M2 muscarinic receptors, causes...
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including support for both native Linux games and those running through Proton, a compatibility layer for Windows games. Additionally, the Steam Deck features...
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GABRE (category Ion channels)
Horenstein J, Akabas MH (2007). "Channel opening by anesthetics and GABA induces similar changes in the GABAA receptor M2 segment". Biophys. J. 92 (9): 3130–3139...
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Mitsubishi Motors (section 1985–2010: Proton)
However, in October 2008, Proton renewed its technology-transfer agreements with MMC, and the Proton Inspira (the Proton Waja replacement) was again...
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vacuoles of plants and yeast and the golgi of animals. They catalyze cation:proton antiport, have a single essential zinc-binding site within the transmembrane...
13 KB (1,461 words) - 01:46, 29 November 2023
- 30 = 23 - 30 = –10. Nath, Pran; Perez, Pavel Fileviez (April 2007). "Proton stability in grand unified theories, in strings, and in branes". Physics...
55 KB (2,726 words) - 18:10, 29 March 2025