Alternative splicing, alternative RNA splicing, or differential splicing, is an alternative splicing process during gene expression that allows a single...
62 KB (7,812 words) - 02:47, 17 February 2025
of RNA splicing occur in nature; the type of splicing depends on the structure of the spliced intron and the catalysts required for splicing to occur...
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However, such transcripts are also produced by splicing errors in a process called "noisy splicing," and are also potentially translated into protein...
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Primary transcript (section Alternative splicing)
expression. Alternative splicing can be affected by various factors, including mutations such as chromosomal translocation. In prokaryotes, splicing is done...
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Serine/arginine-rich splicing factor 1 (SRSF1) also known as alternative splicing factor 1 (ASF1), pre-mRNA-splicing factor SF2 (SF2) or ASF1/SF2 is a...
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is an Argentine molecular biologist who specializes in alternative ribonucleic acid splicing. During his postdoctoral training with Francisco Baralle...
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abundance of alternative splicing, which occurs in most human genes, and the specificity in which splicing is carried out in vivo. Splicing is distinctly...
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due to a variation in a single nucleotide (840.CāT) ā undergoes alternative splicing at the junction of intron 6 to exon 8, with only 10ā20% of SMN2 transcripts...
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SR protein (section Splicing)
and alternative pre-mRNA splicing, mRNA export, genome stabilization, nonsense-mediated decay, and translation. SR proteins alternatively splice pre-mRNA...
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RNA-Seq (section Alternative splicing)
multiple alternative splicing modes: exon skipping (most common splicing mode in humans and higher eukaryotes), mutually exclusive exons, alternative donor...
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RNA-binding protein (section Alternative splicing)
exclusion during splicing. These sites are referred to as exonic splicing enhancers (ESEs), exonic splicing silencers (ESSs), intronic splicing enhancers (ISEs)...
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structure plots of alternative splicing events from .bam, .gtf, and .vcf files. SpliceR An R package for classification of alternative splicing and prediction...
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Evolutionary tinkering (section Alternative splicing)
to a sequence could impact splicing, this process may result in changing the identity of introns and exons; alternatively, the sequence may retain its...
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RBM10 (section Paralogs and splicing network)
chromosome at Xp11.23 in humans. RBM10 is a regulator of alternative splicing. Alternative splicing is a process associated with gene expression to produce...
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TNNT3 (section Alternative splicing)
alternative splicing of multiple exons to generate fsTnT variants, two-dimensional gel electrophoresis detected more than 40 different fsTnT splice forms...
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initiation, polyadenylation and splicing variant data. Alternative Splicing Annotation Project AspicDB RNA splicing Koscielny, Gautier; Le Texier, Vincent;...
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DNA ligase 3 (section Alternative splicing)
encodes several distinct DNA ligase species by alternative translation initiation and alternative splicing mechanisms that are described below. Eukaryotic...
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The primary function is regulation of alternative splicing of associated genes. Several alternatively spliced transcript variants have been found for...
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entirely, alternative splicing creates some transcripts that do not encounter the premature stop codon, ameliorating its effect. mRNA splicing factors such...
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Circular RNA (section Alternative splicing)
examples of alternative splicing is in the Drosophila DSCAM gene, which can give rise to approximately 30 thousand distinct alternatively spliced isoforms...
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Muscleblind Like Splicing Regulator 1 (MBNL1) is an RNA splicing protein that in humans is encoded by the MBNL1 gene. It has a well characterized role...
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still remains an important challenge. As a consequence, the role of alternative splicing in molecular biology remains largely elusive. Third generation sequencing...
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Baltimore classification (section Alternative splicing)
mRNA. Alternative splicing is a mechanism by which different proteins can be produced from a single gene by means of using alternative splicing sites...
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alternative splicing compared to genes that code a single isoform. This is because alternatively spliced mRNAs are enriched in METTL3 binding sites. Splicing is...
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RNA-based evolution (section Alternative splicing)
translation of messenger RNA. Splicing is the process by which non-coding regions of RNA are removed. The number and combination of splicing events varies greatly...
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TNNT1 (section Alternative splicing)
The alternative splice forms of ssTnT play a role in skeletal muscle adaptation in physiologic and pathological conditions. Alternative splicing at alternative...
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Intron (category RNA splicing)
relevant, alternative splicing and processing noise due to splicing errors. One of the central issues in the field of alternative splicing is working out the...
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HIKESHI (section Alternative splicing)
alternate, overlapping exons, and the retention of introns. Besides alternative splicing, the mRNAs differ by truncation on the 3ā end. Variant 1 is one of...
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of splicing factors. In D. melanogaster, Sxl exerts its effects primarily through post-transcriptional regulation, specifically alternative splicing and...
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Neuroligin (section Alternative splicing)
alternative splicing, and certain splice variants of neuroligins and neurexins are more selective for one another. Specific pairing of splice variants also...
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