Directed evolution (DE) is a method used in protein engineering that mimics the process of natural selection to steer proteins or nucleic acids toward...

The term directed evolution is used within the transhumanist community to refer to the idea of applying the principles of directed evolution and experimental...

Evolution is the change in the heritable characteristics of biological populations over successive generations. It occurs when evolutionary processes...

are used for the next round of mutagenesis. Protein Sequence space Directed evolution Protein engineering High-dimensional space DePristo, Mark A.; Weinreich...

general strategies for protein engineering: rational protein design and directed evolution. These methods are not mutually exclusive; researchers will often...

selection as the organizing mechanism in evolution for a rectilinear (straight-line) model of directed evolution. With the emergence of the modern synthesis...

Steinberg, Barrett E. (16 April 2020). "SMOOT libraries and phage-induced directed evolution of Cas9 to engineer reduced off-target activity". PLOS ONE. 15 (4):...

development of directed evolution methods was honored in 2018 with the awarding of the Nobel Prize in Chemistry to Frances Arnold for evolution of enzymes...

Saturation mutagenesis is commonly used to generate variants for directed evolution. Sequence saturation mutagenesis Reetz, M. T.; Carballeira J. D. (2007)...

was awarded the Nobel Prize in Chemistry for pioneering the use of directed evolution to engineer enzymes. In 2019, Alphabet Inc. announced that Arnold...

Phage-assisted continuous evolution (PACE) is a phage-based technique for the automated directed evolution of proteins. It relies on relating the desired...

in vitro random recombination method to generate mutant genes for directed evolution and to enable a rapid increase in DNA library size. Three procedures...

experimental evolution to the control of human evolution. Law professor Maxwell Mehlman has said that "for transhumanists, directed evolution is likened...

Experimental evolution is the use of laboratory experiments or controlled field manipulations to explore evolutionary dynamics. Evolution may be observed...

"Orthogenesis" (goal-directed evolution), "nomogenesis" (evolution according to fixed law), "emergent evolution", "creative evolution", and others. The Jesuit...

design by directed evolution". Annu Rev Biophys. 37: 153–73. doi:10.1146/annurev.biophys.37.032807.125832. PMID 18573077. Maher B. (2009). "Evolution: Biology's...

rapid evolution of useful proteins. The lab has used PACE and its directed evolution efforts to generate new genome editing tools that allow for expanded...

identified by directed evolution. More recently (2024), snowflake yeast were subject to over 3,000 generations of further directed evolution, forming macroscopic...

the function of a protein. Directed evolution is the attempt to engineer proteins using methods inspired by molecular evolution. Change at one locus begins...

German zoologist. He was a popularizer of orthogenesis, a form of directed evolution through mutations that made use of Lamarckian principles. Eimer was...

synthetic biology.). Auxotrophy Biological dark matter Body plan Directed evolution Expanded genetic code Foldamer Hachimoji DNA Hypothetical types of...

(SeSaM) is a chemo-enzymatic random mutagenesis method applied for the directed evolution of proteins and enzymes.[citation needed] It is one of the most common...

outline is provided as an overview of and topical guide to evolution: In biology, evolution is change in the heritable characteristics of biological organisms...

hominins (a tribe of the African hominid subfamily), indicating that human evolution was not linear but weblike. The study of the origins of humans involves...

Alternatives to Darwinian evolution have been proposed by scholars investigating biology to explain signs of evolution and the relatedness of different...

particular organism. Genetic engineering Oncomouse Saturated mutagenesis Directed evolution Hsu PD, Lander ES, Zhang F (June 2014). "Development and applications...

amplified. The StEP protocol has been found to be useful as a method of directed evolution for the discovery of enzymes useful to industry. Zhao, Huimin; Giver...

Teleology in biology is the use of the language of goal-directedness in accounts of evolutionary adaptation, which some biologists and philosophers of...

greater control over human biological nature through a process called directed evolution. Some thinkers believe that this may shatter our sense of self, and...

use. Due to the iterative nature of directed evolution and the necessity for large libraries, directed evolution at the macroscale can be a costly endeavor...