Allopregnanolone is a naturally occurring neurosteroid which is made in the body from the hormone progesterone. As a medication, allopregnanolone is referred...
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Neurosteroid (section Allopregnanolone)
injury. Ganaxolone, a synthetic analog of the endogenous neurosteroid allopregnanolone, is under investigation for the treatment of epilepsy. Based on differences...
41 KB (4,347 words) - 18:35, 7 April 2024
from progesterone. It is also an intermediate in the synthesis of allopregnanolone and isopregnanolone from progesterone. 5α-DHP is metabolized by the...
10 KB (909 words) - 23:12, 9 November 2023
5α-THP), is an endogenous neurosteroid and a natural 3β-epimer of allopregnanolone. It has been reported to act as a subunit-selective negative allosteric...
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is produced in the body from progesterone. It is closely related to allopregnanolone, which has similar properties. Pregnanolone is a positive allosteric...
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a precursor for other neurosteroids such as pregnenolone sulfate, allopregnanolone, and pregnanolone and for steroid hormones. Pregnenolone has low bioavailability...
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include: Progestogens Pregnenolone → Progesterone → Allopregnanedione → Allopregnanolone 17α-Hydroxypregnenolone → 17α-Hydroxyprogesterone Androgens Dehydroepiandrosterone...
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inhibits the production of several anticonvulsant neurosteroids including allopregnanolone, androstanediol, and THDOC. Adverse effects from finasteride are rare;...
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Kavalactones (found in kava) Loreclezole Neuroactive steroids (e.g., allopregnanolone, ganaxolone) Nonbenzodiazepines (e.g., zaleplon, zolpidem, zopiclone...
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because dutasteride may inhibit the conversion of progesterone to allopregnanolone, a neurosteroid metabolite, which may be responsible for some of the...
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synthesized in the lens, and might help make the aqueous humor itself. Allopregnanolone and THDOC are neurosteroids, with the latter having effects on the...
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variant forms 'Allo, a form of Hello Allo, a shortening of allosexual Allopregnanolone, a neurosteroid sometimes abbreviated as "ALLO" 'Allo 'Allo!, a British...
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progesterone receptor. Ganaxolone is an analog of the neurosteroid allopregnanolone that possesses no known hormonal activity and, instead, is thought...
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unable to differentiate between progesterone and metabolites such as allopregnanolone and pregnanolone. As a result, studies that have assessed the pharmacokinetics...
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dehydroepiandrosterone sulfate (DHEA-S), and the inhibitory neurosteroids allopregnanolone, tetrahydrodeoxycorticosterone (THDOC), and 3α-androstanediol, among...
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α-bungarotoxin, α-cobratoxin, α-conotoxin, many others) ABT-126 Alcuronium Allopregnanolone Amantadine Anatruxonium AQW051 Atracurium Barbiturates (e.g., pentobarbital...
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Bromisoval Capuride Carbromal Ectylurea Neuroactive steroids Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone...
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Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org 20599 PF-6372865 Phenibut Picamilon P4S Progabide Propofol Quisqualamine...
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5α-pregnane-3α,20α-diol, is an endogenous metabolite of progesterone and allopregnanolone and an isomer of pregnanediol (5β-pregnan-3α,20α-diol). It has been...
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Methylglyoxal Monastrol Muscimol Nefiracetam Neuroactive steroids (e.g., allopregnanolone) Org 20599 PF-6372865 Phenibut Picamilon P4S Progabide Propofol Quisqualamine...
17 KB (1,632 words) - 16:10, 30 March 2024
Bromisoval Capuride Carbromal Ectylurea Neuroactive steroids Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone...
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Remifentanil Sufentanil Tapentadol Tramadol (Ultram) Certain Neurosteroids Allopregnanolone Ganaxolone Hydroxydione Zuranolone Antidepressants Amoxapine Clomipramine...
24 KB (2,430 words) - 21:51, 19 May 2024
α-bungarotoxin, α-cobratoxin, α-conotoxin, many others) ABT-126 Alcuronium Allopregnanolone Amantadine Anatruxonium AQW051 Atracurium Barbiturates (e.g., pentobarbital...
36 KB (3,397 words) - 01:38, 19 May 2024
Bromisoval Capuride Carbromal Ectylurea Neuroactive steroids Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone...
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AA-861 Allopregnanediol Allopregnanedione (5α-dihydroprogesterone) Allopregnanolone (brexanolone) Alpha-Lipoic acid Ambrisentan AMI-193 Amlodipine besylate...
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neurosteroid active metabolites such as 5α-dihydroprogesterone and allopregnanolone, acts indirectly as a positive allosteric modulator of the GABAA receptor...
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Bromisoval Capuride Carbromal Ectylurea Neuroactive steroids Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone...
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AA-861 Allopregnanediol Allopregnanedione (5α-dihydroprogesterone) Allopregnanolone (brexanolone) Alpha-Lipoic acid Ambrisentan AMI-193 Amlodipine besylate...
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receptor antagonist and MT1 and MT2 receptor agonist Brexanolone (allopregnanolone; Zulresso) – GABAA receptor positive allosteric modulator – approved...
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Bromisoval Capuride Carbromal Ectylurea Neuroactive steroids Acebrochol Allopregnanolone Alphadolone Alphaxolone Eltanolone Hydroxydione Minaxolone Progesterone...
122 KB (15,306 words) - 06:06, 9 May 2024