Clinical endpoints or clinical outcomes are outcome measures referring to occurrence of disease, symptom, sign or laboratory abnormality constituting a...

In clinical trials, a surrogate endpoint (or surrogate marker) is a measure of effect of a specific treatment that may correlate with a real clinical endpoint...

Outcome measure, a measure used as an endpoint in research Clinical endpoint, in clinical research, a disease, symptom, or sign that constitutes one of...

announced in April 2022 that tirzepatide had successfully met its clinical endpoints in obese and overweight participants without diabetes. In industry-funded...

static condition. Progressive disease can also be a clinical endpoint i.e. an endpoint in a clinical trial. A progressive disease should not be confused...

Talwalkar JA (2014). "Association between serum IgE level and adverse clinical endpoints in primary sclerosing cholangitis". Annals of Hepatology. 13 (3):...

Clinical study design is the formulation of clinical trials and other experiments, as well as observational studies, in medical research involving human...

oscillations are emerging as secondary endpoints in clinical trials and in quantifying effects in pre-clinical studies. These biomarkers are often named...

Kleiman, Evan M. (2020). "Suicidal thinking as a valuable clinical endpoint". eClinicalMedicine. 23: 100399. doi:10.1016/j.eclinm.2020.100399. ISSN 2589-5370...

solely on clinical endpoints are very costly as they have long durations and tend to need large numbers of patients. In contrast to clinical endpoints, surrogate...

early clinical development and typically refers to an evaluation of the effect of a new treatment on disease biomarkers, but not the clinical endpoints of...

effectiveness and regulatory approval is controversial. It is often used as a clinical endpoint in randomized controlled trials for cancer therapies. It is a metric...

outcome measure, endpoint, effect measure or measure of effect is a measure within medical practice or research, (primarily clinical trials) which is...

statistical mathematics Clinical trial – Phase of clinical research in medicine Clinical study design – Plan for research in clinical medicine Computer experiment –...

used. The NNT is an important measure in pharmacoeconomics. If a clinical endpoint is devastating enough (e.g. death, heart attack), drugs with a high...

treatment. Many drugs may be abandoned due to their failure to meet a clinical endpoint. Over time, manufacturers wanting to re-investigate the abandoned...

misusing statistics to exaggerate treatment benefits Setting a dubious clinical endpoint in research Advertising a treatment as without side effect Advertising...

types of survival rates (discussed below). They often serve as endpoints of clinical trials and should not be confused with mortality rates, a population...

bakers, a sound evidence base for measurable effects on health related clinical endpoints has not been established". In northern Europe, where bread made from...

endpoint time ratio, which likely would have been close to unity, i.e. mortality was largely the same regardless of group membership and clinically insignificant...

or plaques with central superficial atrophy. Atrophic CLP is the clinical endpoint of chronic annular or hypertrophic LP with atrophic lesions. The use...

interpret a clinical trial endpoint. This is in contrast to traditional single-arm (i.e. non-randomized) clinical trials or randomized clinical trials (RCTs)...

understanding of the trial drug characteristics, or when specific clinical endpoints were measured rather than using surrogate outcomes. Umscheid, Craig...

planned clinical endpoint, but the trial has been criticized as being underpowered, limiting endovascular options, and comparing inappropriate endpoints. As...

trial is a type of prospective, disease-focused, adaptive, randomized clinical trial (RCT) that compares multiple, simultaneous and possibly differently-timed...

point. The acid–base indicator indicates the endpoint of the titration by changing color. The endpoint and the equivalence point are not exactly the...

determining the initial dose regimen to be given to a patient, based on clinical endpoint and on established population pharmacokinetic-pharmacodynamic (PK/PD)...

primary clinical endpoint data is August 2019. As of October 2020, there are multiple therapeutic HPV vaccines in active development and in clinical trials...

randomised, placebo-controlled double-blind clinical trials. However absolutely no effect on clinical endpoints such as CVD or mortality was demonstrated...

studied is beneficial. The endpoints of a clinical trial are usually included in the study objectives. Some examples of endpoints are survival, improvements...