The dopamine transporter (DAT, also sodium-dependent dopamine transporter) is a membrane-spanning protein coded for in humans by the SLC6A3 gene (also...
84 KB (9,214 words) - 21:49, 9 July 2025
by blocking the action of the dopamine transporter (DAT). Reuptake inhibition is achieved when extracellular dopamine not absorbed by the postsynaptic...
19 KB (1,925 words) - 20:34, 17 July 2025
mediated either by the dopamine transporter or by the plasma membrane monoamine transporter. Once back in the cytosol, dopamine can either be broken down...
140 KB (14,364 words) - 07:01, 1 August 2025
three major classes are serotonin transporters (SERTs), dopamine transporters (DATs), and norepinephrine transporters (NETs) and are responsible for the...
21 KB (2,342 words) - 15:34, 14 September 2024
and/or noncompetitively inhibiting the norepinephrine transporter (NET) and dopamine transporter (DAT). NDRIs are used clinically in the treatment of conditions...
6 KB (463 words) - 09:33, 13 July 2025
sodium/chloride-dependent family of neurotransmitter transporters, including dopamine, epinephrine, serotonin and GABA transporters. A single-nucleotide polymorphism (SNP)...
33 KB (3,491 words) - 04:31, 15 July 2025
transport proteins for monoamines (i.e., the dopamine transporter, norepinephrine transporter, and serotonin transporter) in monoamine neurons. Other VMAT2 inhibitors...
29 KB (3,341 words) - 13:54, 1 August 2025
and dopamine by blocking the actions of the serotonin transporter (SERT) and dopamine transporter (DAT), respectively. This in turn leads to increased...
16 KB (1,791 words) - 22:09, 29 May 2025
Dopamine transporter deficiency syndrome (DTDS), also known as infantile parkinsonism-dystonia, is a rare movement disorder that causes progressively worsening...
12 KB (1,211 words) - 04:05, 15 July 2025
binding site overlapping the substrate binding site. The Drosophila dopamine transporter, which displays a pharmacology similar to SERT, was crystallized...
31 KB (3,442 words) - 04:44, 15 July 2025
be due to a ratio between the dopamine transporter and VMAT2. Based on the understanding the increased cytosolic dopamine levels lead to dopaminergic cell...
43 KB (4,993 words) - 05:57, 6 July 2025
been associated with Rage syndrome. A genetic polymorphism in the dopamine transporter gene has been linked to Rage syndrome, and dogs at risk of passing...
29 KB (3,161 words) - 00:35, 7 July 2025
simultaneous inhibition of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), respectively, increasing their...
142 KB (16,607 words) - 17:06, 18 July 2025
List of modafinil analogues and derivatives (category Dopamine reuptake inhibitors)
drugs that specifically target dopamine reuptake (reabsorption of a neurotransmitter by a neurotransmitter transporter) with stronger effects (selective...
36 KB (3,562 words) - 01:47, 3 July 2025
Cocaine (category Serotonin–norepinephrine–dopamine reuptake inhibitors)
Cocaine binds tightly at the dopamine transporter forming a complex that blocks the transporter's function. The dopamine transporter can no longer perform its...
201 KB (20,633 words) - 06:04, 25 July 2025
transporters (MATs), including the serotonin transporter (SERT), norepinephrine transporter (NET), and/or dopamine transporter (DAT), causing them to promote efflux...
264 KB (22,176 words) - 06:34, 19 July 2025
may show reduced dopamine transporter activity. A DLB diagnosis may be warranted if other conditions with reduced dopamine transporter uptake can be ruled...
133 KB (14,330 words) - 03:25, 1 August 2025
uptake of dopamine (DA) by blocking dopamine transporters (DAT). The dopamine transporter controls the dynamics of the neurotransmitter dopamine. This neurotransmitter...
15 KB (1,530 words) - 14:14, 26 May 2025
Rubia K, Rossi G, Sartori G, Balottin U (March 2012). "Striatal dopamine transporter alterations in ADHD: pathophysiology or adaptation to psychostimulants...
274 KB (29,021 words) - 18:17, 30 July 2025
has proven extremely difficult to separate dopamine transporter (DAT) affinity from norepinephrine transporter (NET) affinity and retain releasing capability...
29 KB (3,177 words) - 16:23, 17 July 2025
Dopaminergic (category Dopamine)
facilitate dopamine-related activity. For example, certain proteins such as the dopamine transporter (DAT), vesicular monoamine transporter 2 (VMAT2),...
28 KB (2,826 words) - 20:34, 17 July 2025
norepinephrine, and dopamine by blocking the action of one or more of the respective monoamine transporters (MATs), which include the serotonin transporter (SERT)...
20 KB (1,388 words) - 21:36, 30 January 2025
PRX-14040 (category Dopamine reuptake inhibitors)
selective dopamine reuptake inhibitor that was developed by Prexa Pharmaceuticals. It has 28-fold selectivity for the dopamine transporter over the norepinephrine...
4 KB (187 words) - 08:53, 20 July 2025
(S)-MK-26 (category Dopamine reuptake inhibitors)
has markedly improved potency and selectivity as a blocker of the dopamine transporter (DAT) compared to modafinil (IC50Tooltip half-maximal inhibitory...
5 KB (364 words) - 10:59, 25 July 2025
Monoamine transporters, including: Dopamine transporter (DAT) Norepinephrine transporter (NET) Serotonin transporter (SERT) Vesicular monoamine transporter 1...
9 KB (988 words) - 08:33, 25 May 2025
Locomotor activity (section Dopamine releasing agents)
methylphenidate lose their ability to elevate brain dopamine but not norepinephrine in dopamine transporter (DAT) knockout mice and have been found to decrease...
114 KB (12,382 words) - 04:41, 2 June 2025
Mesolimbic pathway (redirect from Mesolimbic dopamine pathway)
synaptic dopamine through blocking the presynaptic dopamine transporter. Another stimulant, amphetamine, reverses the dopamine transporter and induces...
29 KB (3,487 words) - 21:24, 25 November 2024
Phenylpiracetam (category Norepinephrine–dopamine reuptake inhibitors)
research as dopamine transporter (DAT) inhibitors in rodents, confirming the patent claim. Their actions at the norepinephrine transporter (NET) vary:...
50 KB (4,888 words) - 19:42, 25 July 2025
(dopamine receptor-interacting proteins) interactions. The neurotransmitter dopamine is the primary endogenous ligand for dopamine receptors. Dopamine...
54 KB (5,640 words) - 20:34, 17 July 2025
CE-158 (category Dopamine reuptake inhibitors)
concentration) at the monoamine transporters are 227 nM at the dopamine transporter (DAT), 11,970 nM at the norepinephrine transporter (NET) (53-fold lower), and...
9 KB (884 words) - 07:19, 20 February 2025